Structural Analysis of the Contacts Anchoring Moenomycin to Peptidoglycan Glycosyltransferases and Implications for Antibiotic Design
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Glycosyltransferases and Transpeptidases/Penicillin-Binding Proteins: Valuable Targets for New AntibacterialsCrystal structure of the membrane-bound bifunctional transglycosylase PBP1b from Escherichia coli.Functional and Structural Analysis of a Key Region of the Cell Wall Inhibitor MoenomycinCrystal structure of Staphylococcus aureus transglycosylase in complex with a lipid II analog and elucidation of peptidoglycan synthesis mechanismStructural basis for catalysis at the membrane-water interface.One-pot protection-glycosylation reactions for synthesis of lipid II analoguesGenetic factors that influence moenomycin production in streptomycetesMoenomycin family antibiotics: chemical synthesis, biosynthesis, and biological activityModular synthesis of diphospholipid oligosaccharide fragments of the bacterial cell wall and their use to study the mechanism of moenomycin and other antibiotics.Tuning the moenomycin pharmacophore to enable discovery of bacterial cell wall synthesis inhibitorsABC transporter genes from Streptomyces ghanaensis moenomycin biosynthetic gene cluster: roles in antibiotic production and export.Identification and characterization of Streptomyces ghanaensis ATCC14672 integration sites for three actinophage-based plasmids.Molecular basis and phenotype of methicillin resistance in Staphylococcus aureus and insights into new beta-lactams that meet the challenge.Moenomycin resistance mutations in Staphylococcus aureus reduce peptidoglycan chain length and cause aberrant cell division.MoeH5: a natural glycorandomizer from the moenomycin biosynthetic pathwayThe molecular biology of moenomycins: towards novel antibiotics based on inhibition of bacterial peptidoglycan glycosyltransferases.Chemical tools to discover and target bacterial glycoproteins.Peptidoglycan biosynthesis machinery: a rich source of drug targets.Peptidoglycan glycosyltransferase substrate mimics as templates for the design of new antibacterial drugs.Prospects for new antibiotics: a molecule-centered perspective.Bioactive oligosaccharide natural products.Prospects for novel inhibitors of peptidoglycan transglycosylasesStructural Insights into Inhibition of Escherichia coli Penicillin-binding Protein 1B.The role of the substrate lipid in processive glycan polymerization by the peptidoglycan glycosyltransferases.Deciphering the mode of action of cell wall-inhibiting antibiotics using metabolic labeling of growing peptidoglycan in Streptococcus pyogenes.Complete characterization of the seventeen step moenomycin biosynthetic pathway.A gene cluster for the biosynthesis of moenomycin family antibiotics in the genome of teicoplanin producer Actinoplanes teichomyceticus.Optimization of conditions for the glycosyltransferase activity of penicillin-binding protein 1a from Thermotoga maritima.Design of membrane targeting tobramycin-based cationic amphiphiles with reduced hemolytic activity
P2860
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P2860
Structural Analysis of the Contacts Anchoring Moenomycin to Peptidoglycan Glycosyltransferases and Implications for Antibiotic Design
description
2008 nî lūn-bûn
@nan
2008 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Structural Analysis of the Con ...... ications for Antibiotic Design
@ast
Structural Analysis of the Con ...... ications for Antibiotic Design
@en
Structural Analysis of the Con ...... ications for Antibiotic Design
@nl
type
label
Structural Analysis of the Con ...... ications for Antibiotic Design
@ast
Structural Analysis of the Con ...... ications for Antibiotic Design
@en
Structural Analysis of the Con ...... ications for Antibiotic Design
@nl
prefLabel
Structural Analysis of the Con ...... ications for Antibiotic Design
@ast
Structural Analysis of the Con ...... ications for Antibiotic Design
@en
Structural Analysis of the Con ...... ications for Antibiotic Design
@nl
P2860
P50
P356
P1433
P1476
Structural Analysis of the Con ...... ications for Antibiotic Design
@en
P2093
Suzanne Walker
Yanqiu Yuan
P2860
P304
P356
10.1021/CB800078A
P577
2008-07-18T00:00:00Z