Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspFU
about
A bacterial effector targets host DH-PH domain RhoGEFs and antagonizes macrophage phagocytosisRecognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assemblyInsulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF(U) during pedestal formationSynthetic Protein Scaffolds Based on Peptide Motifs and Cognate Adaptor Domains for Improving Metabolic ProductivityEnterohaemorrhagic Escherichia Coli Exploits a Tryptophan Switch to Hijack Host F-Actin AssemblyMechanism of actin filament nucleation by the bacterial effector VopLStructural basis for complex formation between human IRSp53 and the translocated intimin receptor Tir of enterohemorrhagic E. coli.Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assemblyAllosteric N-WASP activation by an inter-SH3 domain linker in NckConserved interdomain linker promotes phase separation of the multivalent adaptor protein Nck.Membrane-deforming proteins play distinct roles in actin pedestal biogenesis by enterohemorrhagic Escherichia coli.Physical mechanisms of signal integration by WASP family proteins.Hierarchical regulation of WASP/WAVE proteins.Repetitive N-WASP-binding elements of the enterohemorrhagic Escherichia coli effector EspF(U) synergistically activate actin assembly.Dissecting the role of the Tir:Nck and Tir:IRTKS/IRSp53 signalling pathways in vivoEnterohemorrhagic E. coli requires N-WASP for efficient type III translocation but not for EspFU-mediated actin pedestal formation.A transcriptome study of the QseEF two-component system and the QseG membrane protein in enterohaemorrhagic Escherichia coli O157 : H7.Enteropathogenic and enterohaemorrhagic Escherichia coli: even more subversive elements.Insights into the pathogenesis of enteropathogenic E. coli using an improved intestinal enterocyte modelThe effector repertoire of enteropathogenic E. coli: ganging up on the host cellWASP and SCAR/WAVE proteins: the drivers of actin assemblyActivation of PAK by a bacterial type III effector EspG reveals alternative mechanisms of GTPase pathway regulation.The two-component system QseEF and the membrane protein QseG link adrenergic and stress sensing to bacterial pathogenesis.Enterohemorrhagic Escherichia coli raises the I-BAR.Common themes in the design and function of bacterial effectors.Regulation of the actin cytoskeleton-plasma membrane interplay by phosphoinositides.Cytoskeleton-modulating effectors of enteropathogenic and enterohemorrhagic Escherichia coli: a case for EspB as an intrinsically less-ordered effector.Cytoskeleton-modulating effectors of enteropathogenic and enterohaemorrhagic Escherichia coli: Tir, EspFU and actin pedestal assembly.Regulation of WASp by phosphorylation: Activation or other functions?Infection strategies of enteric pathogenic Escherichia coli.Subversion of cell signaling by pathogens.Intimate host attachment: enteropathogenic and enterohaemorrhagic Escherichia coli.Structural features and interfacial properties of WH2, β-thymosin domains and other intrinsically disordered domains in the regulation of actin cytoskeleton dynamics.Extracellular motility and cell-to-cell transmission of enterohemorrhagic E. coli is driven by EspFU-mediated actin assembly.Type III Secreted Virulence Factors Manipulating Signaling to Actin Dynamics.Actin: Structure, Function, Dynamics, and Interactions with Bacterial Toxins.The Shigella Virulence Factor IcsA Relieves N-WASP Autoinhibition by Displacing the Verprolin Homology/Cofilin/Acidic (VCA) DomainThe enteropathogenic E. coli effector EspH promotes actin pedestal formation and elongation via WASP-interacting protein (WIP).The bacterial effectors EspG and EspG2 induce a destructive calpain activity that is kept in check by the co-delivered Tir effector.Multilocus sequence typing and virulence factors analysis of Escherichia coli O157 strains in China.
P2860
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P2860
Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspFU
description
2008 nî lūn-bûn
@nan
2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspFU
@ast
Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspFU
@en
Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspFU
@nl
type
label
Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspFU
@ast
Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspFU
@en
Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspFU
@nl
prefLabel
Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspFU
@ast
Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspFU
@en
Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspFU
@nl
P2093
P2860
P921
P356
P1433
P1476
Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspFU
@en
P2093
Brian M Skehan
Hui-Chun Cheng
John M Leong
Kenneth G Campellone
Michael K Rosen
P2860
P2888
P304
P356
10.1038/NATURE07160
P407
P577
2008-08-21T00:00:00Z
P5875
P6179
1018819538