Structural basis for the catalytic mechanism of human phosphodiesterase 9 - Wikidata - awgldk - TriplyDB

Structural basis for the catalytic mechanism of human phosphodiesterase 9

Structural basis for the catalytic mechanism of human phosphodiesterase 9

http://www.wikidata.org/entity/Q27651858

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Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct Crystal Structure and Computational Analyses Provide Insights into the Catalytic Mechanism of 2,4-Diacetylphloroglucinol Hydrolase PhlG from Pseudomonas fluorescens Insight into Binding of Phosphodiesterase-9A Selective Inhibitors by Crystal Structures and Mutagenesis Structural Asymmetry of Phosphodiesterase-9, Potential Protonation of a Glutamic Acid, and Role of the Invariant Glutamine Structure-Based Discovery of Highly Selective Phosphodiesterase-9A Inhibitors and Implications for Inhibitor Design Dual Specificity and Novel Structural Folding of Yeast Phosphodiesterase-1 for Hydrolysis of Second Messengers Cyclic Adenosine and Guanosine 3′,5′-Monophosphate Cyclic nucleotide phosphodiesterases: important signaling modulators and therapeutic targets.Transcriptional responses of olive flounder (Paralichthys olivaceus) to low temperature.Fundamental reaction pathway and free energy profile for hydrolysis of intracellular second messenger adenosine 3',5'-cyclic monophosphate (cAMP) catalyzed by phosphodiesterase-4.Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor Computational determination of binding structures and free energies of phosphodiesterase-2 with benzo[1,4]diazepin-2-one derivatives.Phosphodiesterase-9 (PDE9) inhibition with BAY 73-6691 increases corpus cavernosum relaxations mediated by nitric oxide-cyclic GMP pathway in mice.Isolation, characterization and molecular 3D model of human GDE4, a novel membrane protein containing glycerophosphodiester phosphodiesterase domain.Role of PDE9 in Cognition.Identification of lead BAY60-7550 analogues as potential inhibitors that utilize the hydrophobic groove in PDE2A: a molecular dynamics simulation study.

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P2860

Structural basis for the catalytic mechanism of human phosphodiesterase 9

http://www.wikidata.org/entity/Q27651858

description

2008 nî lūn-bûn

@nan

2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

@zh-hk

2008年論文

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2008年論文

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2008年论文

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name

Structural basis for the catalytic mechanism of human phosphodiesterase 9

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Structural basis for the catalytic mechanism of human phosphodiesterase 9

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Structural basis for the catalytic mechanism of human phosphodiesterase 9

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type

label

Structural basis for the catalytic mechanism of human phosphodiesterase 9

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Structural basis for the catalytic mechanism of human phosphodiesterase 9

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Structural basis for the catalytic mechanism of human phosphodiesterase 9

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prefLabel

Structural basis for the catalytic mechanism of human phosphodiesterase 9

@ast

Structural basis for the catalytic mechanism of human phosphodiesterase 9

@en

Structural basis for the catalytic mechanism of human phosphodiesterase 9

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PNAS.0708850105

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Structural basis for the catalytic mechanism of human phosphodiesterase 9

@en

P2093

Dennis E Danley

http://www.w3.org/2001/XMLSchema#string

Jose R Perez

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Keith S Dillman

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Mahmoud N Mansour

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Paul A Aeed

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Peter K Lemotte

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Samuel P Simons

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Shenping Liu

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P2860

Identification and characterization of a novel cyclic nucleotide phosphodiesterase gene (PDE9A) that maps to 21q22.3: alternative splicing of mRNA transcripts, genomic structure and sequence

Structural determinants for inhibitor specificity and selectivity in PDE2A using the wheat germ in vitro translation system

Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase

Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor 3-isobutyl-1-methylxanthine binding

Improved methods for building protein models in electron density maps and the location of errors in these models

Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity

Crystal structure of phosphodiesterase 4D and inhibitor complex(1)

Three-dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity

Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules

The crystal structure of AMP-bound PDE4 suggests a mechanism for phosphodiesterase catalysis

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13309-13314

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scholarly article

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10.1073/PNAS.0708850105

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36

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105

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Frank S. Menniti

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2008-08-29T00:00:00Z

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23224111

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18757755

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2533186

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