Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor

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Biopharmaceuticals from microorganisms: from production to purification C33(S), a novel PDE9A inhibitor, protects against rat cardiac hypertrophy through upregulating cGMP signaling.

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Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor

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2015 nî lūn-bûn

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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2015年论文

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2015年论文

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Structural Asymmetry of Phosph ...... Potent Enantiomeric Inhibitor

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Structural Asymmetry of Phosph ...... Potent Enantiomeric Inhibitor

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Structural Asymmetry of Phosph ...... Potent Enantiomeric Inhibitor

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Structural Asymmetry of Phosph ...... Potent Enantiomeric Inhibitor

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Structural Asymmetry of Phosph ...... Potent Enantiomeric Inhibitor

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Structural Asymmetry of Phosph ...... Potent Enantiomeric Inhibitor

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P1476

Structural Asymmetry of Phosph ...... Potent Enantiomeric Inhibitor

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Beibei Liang

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Hai-Bin Luo

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Jianying Hou

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Manna Huang

http://www.w3.org/2001/XMLSchema#string

Peiqing Liu

http://www.w3.org/2001/XMLSchema#string

Wenjun Cui

http://www.w3.org/2001/XMLSchema#string

Xinhai Zhu

http://www.w3.org/2001/XMLSchema#string

Yingchun Huang

http://www.w3.org/2001/XMLSchema#string

Yinuo Wu

http://www.w3.org/2001/XMLSchema#string

Yiqian Wan

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P2860

Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor 3-isobutyl-1-methylxanthine binding

Three-dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity

Structural insight into substrate specificity of phosphodiesterase 10

Crystal structure of the Leishmania major phosphodiesterase LmjPDEB1 and insight into the design of the parasite-selective inhibitors

Conformational Variations of Both Phosphodiesterase-5 and Inhibitors Provide the Structural Basis for the Physiological Effects of Vardenafil and Sildenafil

Structural basis for the catalytic mechanism of human phosphodiesterase 9

Kinetic and Structural Studies of Phosphodiesterase-8A and Implication on the Inhibitor Selectivity † ‡

The active site of an enzyme can host both enantiomers of a racemic ligand simultaneously

Identification of a brain penetrant PDE9A inhibitor utilizing prospective design and chemical enablement as a rapid lead optimization strategy

Insight into Binding of Phosphodiesterase-9A Selective Inhibitors by Crystal Structures and Mutagenesis

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836-845

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scholarly article

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10.1124/MOL.115.099747

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Hengming Ke

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2015-08-27T00:00:00Z

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26316540

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4613944

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Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor

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P2860

P2860

Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor

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P1433

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P433

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