Kinetic and Structural Studies of Phosphodiesterase-8A and Implication on the Inhibitor Selectivity † ‡
about
Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length constructBeclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13Insight into Binding of Phosphodiesterase-9A Selective Inhibitors by Crystal Structures and MutagenesisStructure-Based Discovery of Highly Selective Phosphodiesterase-9A Inhibitors and Implications for Inhibitor DesignBiological and Structural Characterization of Trypanosoma cruzi Phosphodiesterase C and Implications for Design of Parasite Selective InhibitorsPhosphodiesterase-8A binds to and regulates Raf-1 kinaseA phosphodiesterase 2A isoform localized to mitochondria regulates respirationA yeast-based chemical screen identifies a PDE inhibitor that elevates steroidogenesis in mouse Leydig cells via PDE8 and PDE4 inhibitionActive site coupling in PDE:PKA complexes promotes resetting of mammalian cAMP signaling.Atrazine acts as an endocrine disrupter by inhibiting cAMP-specific phosphodiesterase-4Cyclic nucleotide phosphodiesterases: important signaling modulators and therapeutic targets.Discovery of a phosphodiesterase 9A inhibitor as a potential hypoglycemic agentA bioluminescence method for direct measurement of phosphodiesterase activity.Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric InhibitorInteractions between cyclic nucleotide phosphodiesterase 11 catalytic site and substrates or tadalafil and role of a critical Gln-869 hydrogen bond.cAMP-specific phosphodiesterase inhibitors: promising drugs for inflammatory and neurological diseases.PDE5 expression in human thyroid tumors and effects of PDE5 inhibitors on growth and migration of cancer cells.Somatic amplifications and deletions in genome of papillary thyroid carcinomas.Refolding and kinetic characterization of the phosphodiesterase-8A catalytic domain.Discovery of novel PDE9A inhibitors with antioxidant activities for treatment of Alzheimer's disease.PDE8 is Expressed in Human Airway Smooth Muscle and Selectively Regulates cAMP Signaling by β2AR-AC6.Channeling of cAMP in PDE-PKA Complexes Promotes Signal Adaptation.
P2860
Q24336151-3E1AAF13-5540-4EF9-A95A-E6FB7E0C99F1Q24338972-8F56E4B1-CAF9-4E73-8FFA-18F1B24AC5CBQ27659336-197391BB-507E-4535-AF7F-FAE9A0E01997Q27673292-CA829151-134A-443A-ADED-9A2075CF0BA0Q27677423-AF2CB45D-A895-4F1A-BFA7-358520722786Q28118406-7AB90782-C856-408F-8427-39322568679FQ28506723-8DD8D7EA-E52E-4896-85B0-4FDFB64456B9Q28535340-CE28EDA4-327C-4D9E-968C-D36BF61394B3Q34205089-49BF1761-1EF0-415E-A995-B06BC6F73DC3Q34274198-5E8E3A63-1DAB-45A0-BB25-FC38DB1DD0C4Q34765802-8A93956A-753A-4BCB-BD28-AF6DD88692BAQ34796444-6A92FA5B-167D-4DE6-B03E-7BE9E8B0F32CQ35155047-C843A3D2-6949-4925-8370-26FE36C82A87Q36186122-B193C795-B159-4192-9C45-0E8B2CAF5EE5Q37397220-1DBEB053-409C-45CB-A7CE-B0EE387ADD1DQ38256936-F85EAC08-836E-4B07-B62E-5AB7A7C363A4Q38891514-37B46D5E-4015-496B-AE38-61E4392DA50FQ41088523-52DEE289-3B5A-4FBE-BA95-221383F0C12FQ41871350-6946C540-B77B-419A-87EF-124A037686BEQ47225388-2FC8BBBC-E527-4E7A-949E-72D59AC86002Q47275656-862A52F3-BD14-4555-8FD2-4024C0EF01F6Q50931781-511115B4-3089-44D2-A8DC-42A1355F4D7F
P2860
Kinetic and Structural Studies of Phosphodiesterase-8A and Implication on the Inhibitor Selectivity † ‡
description
2008 nî lūn-bûn
@nan
2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Kinetic and Structural Studies ...... the Inhibitor Selectivity † ‡
@ast
Kinetic and Structural Studies ...... the Inhibitor Selectivity † ‡
@en
Kinetic and Structural Studies ...... the Inhibitor Selectivity † ‡
@nl
type
label
Kinetic and Structural Studies ...... the Inhibitor Selectivity † ‡
@ast
Kinetic and Structural Studies ...... the Inhibitor Selectivity † ‡
@en
Kinetic and Structural Studies ...... the Inhibitor Selectivity † ‡
@nl
prefLabel
Kinetic and Structural Studies ...... the Inhibitor Selectivity † ‡
@ast
Kinetic and Structural Studies ...... the Inhibitor Selectivity † ‡
@en
Kinetic and Structural Studies ...... the Inhibitor Selectivity † ‡
@nl
P2093
P2860
P356
P1433
P1476
Kinetic and Structural Studies ...... the Inhibitor Selectivity † ‡
@en
P2093
Howard Robinson
Huanchen Wang
Serena Yang
P2860
P304
P356
10.1021/BI801487X
P407
P50
P577
2008-12-02T00:00:00Z