A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B
about
A Cell Biologist's Field Guide to Aurora Kinase InhibitorsCrystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug designDevelopment of o -Chlorophenyl Substituted Pyrimidines as Exceptionally Potent Aurora Kinase InhibitorsSelective Aurora Kinase Inhibitors Identified Using a Taxol-Induced Checkpoint Sensitivity ScreenAurora isoform selectivity: design and synthesis of imidazo[4,5-b]pyridine derivatives as highly selective inhibitors of Aurora-A kinase in cells.Molecular mechanism of Aurora A kinase autophosphorylation and its allosteric activation by TPX2Issues in interpreting the in vivo activity of Aurora-AAurora kinases as druggable targets in pediatric leukemia: heterogeneity in target modulation activities and cytotoxicity by diverse novel therapeutic agents.Overcoming CML acquired resistance by specific inhibition of Aurora A kinase in the KCL-22 cell model.Simple di- and trivanillates exhibit cytostatic properties toward cancer cells resistant to pro-apoptotic stimuli.Mitotic phosphorylation of SOX2 mediated by Aurora kinase A is critical for the stem-cell like cell maintenance in PA-1 cells.Stathmin and microtubules regulate mitotic entry in HeLa cells by controlling activation of both Aurora kinase A and Plk1.Purification, crystallization and preliminary X-ray diffraction analysis of the kinase domain of human tousled-like kinase 2.Aurora kinase inhibitors: progress towards the clinicSynthesis and SAR of 4-(pyrazol-3-yl)-pyridines as novel c-jun N-terminal kinase inhibitorsDiscovery of a Potent, Injectable Inhibitor of Aurora Kinases Based on the Imidazo-[1,2-a]-Pyrazine Core.AURKA suppression induces DU145 apoptosis and sensitizes DU145 to docetaxel treatment.The molecular mechanism studies of chirality effect of PHA-739358 on Aurora kinase A by molecular dynamics simulation and free energy calculations.Combined 3D-QSAR modeling and molecular docking studies on pyrrole-indolin-2-ones as Aurora A kinase inhibitors.Novel pyrimidine-2,4-diamine derivative suppresses the cell viability and spindle assembly checkpoint activity by targeting Aurora kinases.Plk4 and Aurora A cooperate in the initiation of acentriolar spindle assembly in mammalian oocytes.Phthalazinone Pyrazole Enhances the Hepatic Functions of Human Embryonic Stem Cell-Derived Hepatocyte-Like Cells via Suppression of the Epithelial-Mesenchymal Transition.Classification of Aurora-A Kinase Inhibitors Using Self-Organizing Map (SOM) and Support Vector Machine (SVM).Synthesis and structure elucidation of polyphenols containing the N'-methyleneformohydrazide scaffold as aurora kinase inhibitors.A MYC-aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer.SAR study on N2,N4-disubstituted pyrimidine-2,4-diamines as effective CDK2/CDK9 inhibitors and antiproliferative agents.Synthesis and profiling of a 3-aminopyridin-2-one-based kinase targeted fragment library: Identification of 3-amino-5-(pyridin-4-yl)pyridin-2(1H)-one scaffold for monopolar spindle 1 (MPS1) and Aurora kinases inhibition.3D-QSAR and molecular docking studies of azaindole derivatives as Aurora B kinase inhibitors.
P2860
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P2860
A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B
description
2009 nî lūn-bûn
@nan
2009 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
A class of 2,4-bisanilinopyrim ...... h selectivity against Aurora B
@ast
A class of 2,4-bisanilinopyrim ...... h selectivity against Aurora B
@en
A class of 2,4-bisanilinopyrim ...... h selectivity against Aurora B
@nl
type
label
A class of 2,4-bisanilinopyrim ...... h selectivity against Aurora B
@ast
A class of 2,4-bisanilinopyrim ...... h selectivity against Aurora B
@en
A class of 2,4-bisanilinopyrim ...... h selectivity against Aurora B
@nl
prefLabel
A class of 2,4-bisanilinopyrim ...... h selectivity against Aurora B
@ast
A class of 2,4-bisanilinopyrim ...... h selectivity against Aurora B
@en
A class of 2,4-bisanilinopyrim ...... h selectivity against Aurora B
@nl
P2093
P356
P1476
A class of 2,4-bisanilinopyrim ...... h selectivity against Aurora B
@en
P2093
Bing-Yan Zhu
Birong Zhang
Carter Fields
Christian Wiesmann
Dan Burdick
Elaine Krueger
Gail Phillips
Ignacio Aliagas-Martin
Jason Drummond
Jennafer Dotson
P304
P356
10.1021/JM9000314
P407
P577
2009-05-28T00:00:00Z