A MYC-aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer. - Wikidata - awgldk - TriplyDB

A MYC-aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer.

A MYC-aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer.

http://www.wikidata.org/entity/Q48225584

about

N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway.Time, space, and disorder in the expanding proteome universe.c-MYC-Making Liver Sick: Role of c-MYC in Hepatic Cell Function, Homeostasis and Disease.Hepatoblastoma modeling in mice places Nrf2 within a cancer field established by mutant β-catenin.Aurora A Kinase Inhibitor AKI603 Induces Cellular Senescence in Chronic Myeloid Leukemia Cells Harboring T315I Mutation.TP53 mutations, expression and interaction networks in human cancers Accelerating drug development for neuroblastoma - New Drug Development Strategy: an Innovative Therapies for Children with Cancer, European Network for Cancer Research in Children and Adolescents and International Society of Paediatric Oncology Euro Cisplatin-resistant cancer cells are sensitive to Aurora kinase A inhibition by alisertib.Activation of EIF4E by Aurora Kinase A Depicts a Novel Druggable Axis in Everolimus-Resistant Cancer Cells.Modeling and Targeting MYC Genes in Childhood Brain Tumors.The MYCN Protein in Health and Disease.Family matters: How MYC family oncogenes impact small cell lung cancer.Association between the functional polymorphism Ile31Phe in the AURKA gene and susceptibility of hepatocellular carcinoma in chronic hepatitis B virus carriers.Liver Cancer: Molecular Characterization, Clonal Evolution and Cancer Stem Cells.Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain.Transcriptome Analysis Uncovers a Growth-Promoting Activity of Orosomucoid-1 on Hepatocytes.An in vivo transfection system for inducible gene expression and gene silencing in murine hepatocytes.Combinatorial genetics in liver repopulation and carcinogenesis with a novel in vivo CRISPR activation platform.Association with Aurora-A Controls N-MYC-Dependent Promoter Escape and Pause Release of RNA Polymerase II during the Cell Cycle.Polo-like-kinase 1 (PLK-1) and c-myc inhibition with the dual kinase-bromodomain inhibitor volasertib in aggressive lymphomas.Spatial Tissue Proteomics Quantifies Inter- and Intratumor Heterogeneity in Hepatocellular Carcinoma (HCC).Prevention of hepatocellular carcinoma by targeting MYCN-positive liver cancer stem cells with acyclic retinoid.Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma.Identification of The Aberrantly Expressed LncRNAs in Hepatocellular Carcinoma: A Bioinformatics Analysis Based on RNA-sequencing.Precision medicine based on surgical oncology in the era of genome-scale analysis and genome editing technology.Identification of key candidate genes and pathways in hepatocellular carcinoma by integrated bioinformatical analysis.Analysis of potential genes associated with primary cilia in bladder cancer The functional diversity of Aurora kinases: a comprehensive review Therapeutic targeting of Aurora A kinase in Philadelphia chromosome-positive ABL tyrosine kinase inhibitor-resistant cells

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P2860

A MYC-aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer.

http://www.wikidata.org/entity/Q48225584

description

2016 nî lūn-bûn

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2016年の論文

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2016年学术文章

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2016年学术文章

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2016年学术文章

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2016年学术文章

@zh-hans

2016年学术文章

@zh-my

2016年学术文章

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2016年學術文章

@yue

2016年學術文章

@zh-hant

name

A MYC-aurora kinase A protein ...... t in p53-altered liver cancer.

@en

A MYC-aurora kinase A protein ...... t in p53-altered liver cancer.

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type

label

A MYC-aurora kinase A protein ...... t in p53-altered liver cancer.

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A MYC-aurora kinase A protein ...... t in p53-altered liver cancer.

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prefLabel

A MYC-aurora kinase A protein ...... t in p53-altered liver cancer.

@en

A MYC-aurora kinase A protein ...... t in p53-altered liver cancer.

@nl

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Nature Medicine

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A MYC-aurora kinase A protein ...... t in p53-altered liver cancer.

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Anja Hohmeyer

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Daniel Dauch

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Lars Zender

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Lisa Hoenicke

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Nisar P Malek

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Przemyslaw Bozko

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Ramona Rudalska

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Tae-Won Kang

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Thomas Longerich

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Torsten Wuestefeld

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P2860

Small molecule inhibitors of aurora-a induce proteasomal degradation of N-myc in childhood neuroblastoma

Drugging MYCN through an allosteric transition in Aurora kinase A

Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma

Senescence of activated stellate cells limits liver fibrosis

Caspase 8 small interfering RNA prevents acute liver failure in mice

Aurora kinase A in gastrointestinal cancers: time to target

A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

Divorcing ARF and p53: an unsettled case

Aurora A, meiosis and mitosis

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744-753

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10.1038/NM.4107

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7

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22

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Sandrine Imbeaud

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Jean Charles Nault

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2016-05-23T00:00:00Z

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1027948943

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27213815

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