Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064

Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064

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http://www.wikidata.org/entity/Q27655353
Exposure to the synthetic FXR agonist GW4064 causes alterations in gene expression and sublethal hepatotoxicity in eleutheroembryo medaka (Oryzias latipes)Pharmacophore-based discovery of FXR agonists. Part I: Model development and experimental validation.Conformational dynamics of human FXR-LBD ligand interactions studied by hydrogen/deuterium exchange mass spectrometry: insights into the antagonism of the hypolipidemic agent Z-guggulsterone.Development of time resolved fluorescence resonance energy transfer-based assay for FXR antagonist discoveryChallenges and opportunities in drug and biomarker development for nonalcoholic steatohepatitis: findings and recommendations from an American Association for the Study of Liver Diseases-U.S. Food and Drug Administration Joint WorkshopFarnesoid X receptor modulators: a patent review.Medicinal chemistry of farnesoid X receptor ligands: from agonists and antagonists to modulators.Characterizing ligands for farnesoid X receptor--available in vitro test systems for farnesoid X receptor modulator development.Combining self- and cross-docking as benchmark tools: the performance of DockBench in the D3R Grand Challenge 2.Role of farnesoid X receptor in cholestasis.Design, Synthesis, and Biological Evaluation of Novel Nonsteroidal Farnesoid X Receptor (FXR) Antagonists: Molecular Basis of FXR Antagonism.Antidiabetic sulfonylureas modulate farnesoid X receptor activation and target gene transcription.Simultaneous diastereo- and enantioseparation of farnesoid X receptor (FXR) agonists with a quinine carbamate-based chiral stationary phase.Using physics-based pose predictions and free energy perturbation calculations to predict binding poses and relative binding affinities for FXR ligands in the D3R Grand Challenge 2.
P2860

Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064

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http://www.wikidata.org/entity/Q27655353
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064
@ast
Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064
@en
Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064
@nl
type
label
Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064
@ast
Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064
@en
Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064
@nl
prefLabel
Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064
@ast
Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064
@en
Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064
@nl
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P698
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Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064
@en
P2093
P304
P31
P356
10.1016/J.BMCL.2009.04.047
P407
P433
P478
P50
P577
P698