Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors
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Effect of ligand binding on human D-amino acid oxidase: implications for the development of new drugs for schizophrenia treatment3-Hydroxyquinolin-2(1 H )-ones As Inhibitors of Influenza A EndonucleaseNovel human ᴅ-amino acid oxidase inhibitors stabilize an active-site lid-open conformationPhenyl substituted 4-hydroxypyridazin-3(2H)-ones and 5-hydroxypyrimidin-4(3H)-ones: inhibitors of influenza A endonuclease.Potential primary roles of glial cells in the mechanisms of psychiatric disorders.The neurobiology of D-amino acid oxidase and its involvement in schizophrenia.Synthesis and SAR of 1-hydroxy-1H-benzo[d]imidazol-2(3H)-ones as Inhibitors of D-Amino Acid Oxidase.Effects of D-amino acid oxidase inhibition on memory performance and long-term potentiation in vivo.Structure-Metabolism Relationships in the Glucuronidation of d-Amino Acid Oxidase Inhibitors.A molecular mechanics approach to modeling protein-ligand interactions: relative binding affinities in congeneric series.D-Amino acid oxidase-mediated increase in spinal hydrogen peroxide is mainly responsible for formalin-induced tonic pain.Discovery, synthesis and biochemical profiling of purine-2,6-dione derivatives as inhibitors of the human poly(A)-selective ribonuclease Caf1.D-Amino acid oxidase inhibitors based on the 5-hydroxy-1,2,4-triazin-6(1H)-one scaffold.D-Amino-Acid Oxidase Inhibition Increases D-Serine Plasma Levels in Mouse But not in Monkey or Dog.Carboxylic acid (bio)isosteres in drug design.Synthesis of kojic acid derivatives as secondary binding site probes of D-amino acid oxidase6-Hydroxy-1,2,4-triazine-3,5(2H,4H)-dione Derivatives as Novel D-Amino Acid Oxidase InhibitorsD-serine and schizophrenia: an update.Heterocycles as nonclassical bioisosteres of α-amino acids.D-amino acid oxidase is expressed in the ventral tegmental area and modulates cortical dopamine.Optimizing the Physicochemical Properties of Raf/MEK Inhibitors by Nitrogen Scanning.Alteration in the plasma concentration of a DAAO inhibitor, 3-methylpyrazole-5-carboxylic acid, in the ketamine-treated rats and the influence on the pharmacokinetics of plasma D-tryptophan.The Therapeutic Potential of D-Amino Acid Oxidase (DAAO) Inhibitors.Competitive Inhibitors Unveil Structure/Function Relationships in Human D-Amino Acid Oxidase.Validation of tautomeric and protomeric binding modes by free energy calculations. A case study for the structure based optimization of D-amino acid oxidase inhibitors.D-Glucosamine as a green ligand for copper catalyzed synthesis of primary aryl amines from aryl halides and ammonia.Elucidation of inhibitor-binding pockets of d-amino acid oxidase using docking simulation and N-sulfanylethylanilide-based labeling technology.Biochemical Properties of Human D-amino Acid Oxidase Variants and Their Potential Significance in Pathologies.
P2860
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P2860
Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Discovery, SAR, and pharmacoki ...... acid oxidase (DAAO) inhibitors
@ast
Discovery, SAR, and pharmacoki ...... acid oxidase (DAAO) inhibitors
@en
Discovery, SAR, and pharmacoki ...... acid oxidase (DAAO) inhibitors
@nl
type
label
Discovery, SAR, and pharmacoki ...... acid oxidase (DAAO) inhibitors
@ast
Discovery, SAR, and pharmacoki ...... acid oxidase (DAAO) inhibitors
@en
Discovery, SAR, and pharmacoki ...... acid oxidase (DAAO) inhibitors
@nl
prefLabel
Discovery, SAR, and pharmacoki ...... acid oxidase (DAAO) inhibitors
@ast
Discovery, SAR, and pharmacoki ...... acid oxidase (DAAO) inhibitors
@en
Discovery, SAR, and pharmacoki ...... acid oxidase (DAAO) inhibitors
@nl
P2093
P356
P1476
Discovery, SAR, and pharmacoki ...... acid oxidase (DAAO) inhibitors
@en
P2093
Ayman El-Kattan
Boris A Chrunyk
Christine A Strick
James T Downs
Kris A Borzilleri
Lain-Yen Hu
Larry C James
Mahmoud N Mansour
P304
P356
10.1021/JM900128W
P407
P577
2009-06-01T00:00:00Z