N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275
about
Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1)11β-Hydroxysteroid dehydrogenase type 1: relevance of its modulation in the pathophysiology of obesity, the metabolic syndrome and type 2 diabetes mellitus.Human hydroxysteroid dehydrogenases and pre-receptor regulation: insights into inhibitor design and evaluation.Crystal structures of 11β-hydroxysteroid dehydrogenase type 1 and their use in drug discovery.Practical approaches to resolving reactive metabolite liabilities in early discovery.Modulation of 11beta-hydroxysteroid dehydrogenase type 1 activity by 1,5-substituted 1H-tetrazolesReaction phenotyping to assess victim drug-drug interaction risks.First Selective CYP11B1 Inhibitors for the Treatment of Cortisol-Dependent DiseasesPharmacokinetic characterization of 2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone, a novel 11β-hydroxysteroid dehydrogenase type 1 inhibitor in rats.
P2860
Q27684779-659F1B09-618D-4C78-8CF2-F65C1C0687C5Q34253331-133283D9-31FA-4C2C-9AFE-10EBC503A286Q35013689-190A367A-2CE7-4A46-BBD4-146E9C8BB486Q37859010-A4E05B57-27A2-426C-9A4F-EBD372D4E418Q38269781-F95A09B7-2054-44A1-A0BB-B4D0F448E38DQ38589121-E7C9238A-3204-4D9D-9833-930BB0D6E100Q38640403-79F9A9A3-8A07-4C90-B2AE-643031D7F577Q39514041-3AEA08AC-69AB-4E56-9E7F-96ED0DEE3E32Q53208462-EF88023B-6C96-4242-B42F-51952B2FB6EB
P2860
N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275
description
2009 nî lūn-bûn
@nan
2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
N-(Pyridin-2-yl) arylsulfonami ...... type 1: Discovery of PF-915275
@ast
N-(Pyridin-2-yl) arylsulfonami ...... type 1: Discovery of PF-915275
@en
N-(Pyridin-2-yl) arylsulfonami ...... type 1: Discovery of PF-915275
@nl
type
label
N-(Pyridin-2-yl) arylsulfonami ...... type 1: Discovery of PF-915275
@ast
N-(Pyridin-2-yl) arylsulfonami ...... type 1: Discovery of PF-915275
@en
N-(Pyridin-2-yl) arylsulfonami ...... type 1: Discovery of PF-915275
@nl
prefLabel
N-(Pyridin-2-yl) arylsulfonami ...... type 1: Discovery of PF-915275
@ast
N-(Pyridin-2-yl) arylsulfonami ...... type 1: Discovery of PF-915275
@en
N-(Pyridin-2-yl) arylsulfonami ...... type 1: Discovery of PF-915275
@nl
P2093
P1476
N-(Pyridin-2-yl) arylsulfonami ...... type 1: Discovery of PF-915275
@en
P2093
Amy LaPaglia
Andrea N Fanjul
Arturo Castro
Jacques Ermolieff
Jean J Matthews
Jennifer E Vogel
Martin P Edwards
Michael Siu
Natilie A Hosea
Sajiv K Nair
P304
P356
10.1016/J.BMCL.2009.05.011
P407
P577
2009-07-01T00:00:00Z