Structural and Functional Analysis of Sulfolobus solfataricus Y-Family DNA Polymerase Dpo4-Catalyzed Bypass of the Malondialdehyde−Deoxyguanosine Adduct ,
about
A rescue act: Translesion DNA synthesis past N(2) -deoxyguanosine adductsStructure of the 1, N 2 -Etheno-2′-deoxyguanosine Lesion in the 3′-G(εdG)T-5′ Sequence Opposite a One-Base DeletionMetal-ion dependence of the active-site conformation of the translesion DNA polymerase Dpo4 fromSulfolobus solfataricusReplication Bypass of the trans -4-Hydroxynonenal-Derived (6 S ,8 R ,11 S )-1, N 2 -Deoxyguanosine DNA Adduct by the Sulfolobus solfataricus DNA Polymerase IVRing-Opening of the γ-OH-PdG Adduct Promotes Error-Free Bypass by the Sulfolobus solfataricus DNA Polymerase Dpo4Comparison of the in vitro replication of the 7-(2-oxoheptyl)-1,N2-etheno-2'-deoxyguanosine and 1,N2-etheno-2'-deoxyguanosine lesions by Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4)Structural and kinetic insights into binding and incorporation of L-nucleotide analogs by a Y-family DNA polymeraseTranslesion DNA Synthesis.DNA pol λ's extraordinary ability to stabilize misaligned DNA.Differential temperature-dependent multimeric assemblies of replication and repair polymerases on DNA increase processivity.Translesion synthesis across 1,N6-(2-hydroxy-3-hydroxymethylpropan-1,3-diyl)-2'-deoxyadenosine (1,N6-γ-HMHP-dA) adducts by human and archebacterial DNA polymerases.Frameshift deletion by Sulfolobus solfataricus P2 DNA polymerase Dpo4 T239W is selective for purines and involves normal conformational change followed by slow phosphodiester bond formationChemistry and structural biology of DNA damage and biological consequencesMechanistic Studies with DNA Polymerases Reveal Complex Outcomes following Bypass of DNA Damage.In vitro bypass of the major malondialdehyde- and base propenal-derived DNA adduct by human Y-family DNA polymerases κ, ι, and Rev1.Escherichia coli Fpg glycosylase is nonrendundant and required for the rapid global repair of oxidized purine and pyrimidine damage in vivoSynthesis of oligonucleotides containing 2-N-heteroarylguanine residues and their effect on duplex/triplex stability.Computational Evaluation of Nucleotide Insertion Opposite Expanded and Widened DNA by the Translesion Synthesis Polymerase Dpo4.
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P2860
Structural and Functional Analysis of Sulfolobus solfataricus Y-Family DNA Polymerase Dpo4-Catalyzed Bypass of the Malondialdehyde−Deoxyguanosine Adduct ,
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2009 nî lūn-bûn
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2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
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2009 թվականի օգոստոսին հրատարակված գիտական հոդված
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2009年の論文
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2009年論文
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2009年論文
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2009年論文
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2009年論文
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2009年論文
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2009年论文
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name
Structural and Functional Anal ...... dehyde−Deoxyguanosine Adduct ,
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Structural and Functional Anal ...... dehyde−Deoxyguanosine Adduct ,
@en
Structural and Functional Anal ...... dehyde−Deoxyguanosine Adduct ,
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type
label
Structural and Functional Anal ...... dehyde−Deoxyguanosine Adduct ,
@ast
Structural and Functional Anal ...... dehyde−Deoxyguanosine Adduct ,
@en
Structural and Functional Anal ...... dehyde−Deoxyguanosine Adduct ,
@nl
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Structural and Functional Anal ...... dehyde−Deoxyguanosine Adduct ,
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Structural and Functional Anal ...... dehyde−Deoxyguanosine Adduct ,
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Structural and Functional Anal ...... dehyde−Deoxyguanosine Adduct ,
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P2860
P356
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Structural and Functional Anal ...... dehyde−Deoxyguanosine Adduct ,
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P2093
Carmelo J Rizzo
F Peter Guengerich
Jennifer B Stafford
Jozsef Szekely
Lawrence J Marnett
Robert L Eoff
P2860
P304
P356
10.1021/BI9003588
P407
P50
P577
2009-08-04T00:00:00Z