Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor - Wikidata - awgldk - TriplyDB

Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor

Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor

http://www.wikidata.org/entity/Q27655786

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Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex A heterodimeric complex of the LRR proteins LRIM1 and APL1C regulates complement-like immunity in Anopheles gambiae Structures of C3b in complex with factors B and D give insight into complement convertase formation Bacterial Toxins as Pathogen Weapons Against Phagocytes Antimicrobial Mechanisms of Macrophages and the Immune Evasion Strategies of Staphylococcus aureus Putting the structure into complement Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b A structural basis for Staphylococcal complement subversion: X-ray structure of the complement-binding domain of Staphylococcus aureus protein Sbi in complex with ligand C3d A Structurally Dynamic N-terminal Helix Is a Key Functional Determinant in Staphylococcal Complement Inhibitor (SCIN) Proteins Diversity in the C3b Convertase Contact Residues and Tertiary Structures of the Staphylococcal Complement Inhibitor (SCIN) Protein Family Inhibiting Alternative Pathway Complement Activation by Targeting the Factor D Exosite Structure ofStreptococcus agalactiaetip pilin GBS104: a model for GBS pili assembly and host interactions Crystal Structure of C5b-6 Suggests Structural Basis for Priming Assembly of the Membrane Attack Complex Structural basis for therapeutic inhibition of complement C5 Complement System Part II: Role in Immunity Complement: a key system for immune surveillance and homeostasis A humanized antibody that regulates the alternative pathway convertase: potential for therapy of renal disease associated with nephritic factors Structural basis for the stabilization of the complement alternative pathway C3 convertase by properdin.A prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain of function.Use of eculizumab for atypical haemolytic uraemic syndrome and C3 glomerulopathies.Complement factor B mutations in atypical hemolytic uremic syndrome-disease-relevant or benign?Mapping interactions between complement C3 and regulators using mutations in atypical hemolytic uremic syndrome.Staphylococcus aureus degrades neutrophil extracellular traps to promote immune cell death.Convertase inhibitory properties of Staphylococcal extracellular complement-binding protein.A molecular insight into complement evasion by the staphylococcal complement inhibitor protein family Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation.Allosteric inhibition of complement function by a staphylococcal immune evasion protein.Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b.Complement System Part I - Molecular Mechanisms of Activation and Regulation.A revised mechanism for the activation of complement C3 to C3b: a molecular explanation of a disease-associated polymorphism Phagocytosis escape by a Staphylococcus aureus protein that connects complement and coagulation proteins at the bacterial surface Unique structure of iC3b resolved at a resolution of 24 Å by 3D-electron microscopy Rare loss-of-function mutation in complement component C3 provides insight into molecular and pathophysiological determinants of complement activity Compstatin: a C3-targeted complement inhibitor reaching its prime for bedside intervention.Access to the complement factor B scissile bond is facilitated by association of factor B with C3b protein.Identification of peptidic inhibitors of the alternative complement pathway based on Staphylococcus aureus SCIN proteins.Role of complement and complement regulatory proteins in the complications of diabetes The Sbi Protein Contributes to Staphylococcus aureus Inflammatory Response during Systemic Infection.Antibody directs properdin-dependent activation of the complement alternative pathway in a mouse model of abdominal aortic aneurysm

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Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor

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2009 nî lūn-bûn

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Structural and functional impl ...... by a staphylococcal inhibitor

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Structural and functional impl ...... by a staphylococcal inhibitor

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Structural and functional impl ...... by a staphylococcal inhibitor

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Nature Immunology

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Structural and functional impl ...... by a staphylococcal inhibitor

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Apostolia Tzekou

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Jin Wu

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Karel L Planken

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Maartje Ruyken

http://www.w3.org/2001/XMLSchema#string

Piet Gros

http://www.w3.org/2001/XMLSchema#string

Robert van Domselaar

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Suzan H M Rooijakkers

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P2860

Structure/function of C5 convertases of complement

The Crystal Structure of C2a, the Catalytic Fragment of Classical Pathway C3 and C5 Convertase of Human Complement

Factor B structure provides insights into activation of the central protease of the complement system

Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition

Staphylococcal complement inhibitor: structure and active sites

Structure of and influence of a tick complement inhibitor on human complement component 5

Structural and Functional Analysis of a C3b-specific Antibody That Selectively Inhibits the Alternative Pathway of Complement

Coot: model-building tools for molecular graphics

Phasercrystallographic software

PHENIX: building new software for automated crystallographic structure determination

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721-727

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scholarly article

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3720424

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10.1038/NI.1756

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7

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10

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John D. Lambris

Jos A. G. Van Strijp

Bert J C Janssen

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2009-06-07T00:00:00Z

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26273021

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19503103

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2729104

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