Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase - Wikidata - awgldk - TriplyDB

Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase

Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase

http://www.wikidata.org/entity/Q27657397

about

Discovery of inhibitors of soluble epoxide hydrolase: a target with multiple potential therapeutic indications Impact of soluble epoxide hydrolase and epoxyeicosanoids on human health Discovery of MK-8718, an HIV Protease Inhibitor Containing a Novel Morpholine Aspartate Binding Group Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides Fragment Screening of Soluble Epoxide Hydrolase for Lead Generation-Structure-Based Hit Evaluation and Chemistry Exploration 18F-FNDP for PET Imaging of Soluble Epoxide Hydrolase (sEH)Incorporation of piperazino functionality into 1,3-disubstituted urea as the tertiary pharmacophore affording potent inhibitors of soluble epoxide hydrolase with improved pharmacokinetic properties.Structure-activity relationships of substituted oxyoxalamides as inhibitors of the human soluble epoxide hydrolase.The role of epoxide hydrolases in health and disease.Single-residue posttranslational modification sites at the N-terminus, C-terminus or in-between: To be or not to be exposed for enzyme access Förster resonance energy transfer competitive displacement assay for human soluble epoxide hydrolase.Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides.Investigation of the binding mode of 1, 3, 4-oxadiazole derivatives as amide-based inhibitors for soluble epoxide hydrolase (sEH) by molecular docking and MM-GBSA.Microsomal cytochrome P450 as a target for drug discovery and repurposing.1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain.Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening Molecular Imaging of Hydrolytic Enzymes Using PET and SPECT.1-(1-acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia A systematic analysis of atomic protein-ligand interactions in the PDB.Novel piperidine-derived amide sEH inhibitors as mediators of lipid metabolism with improved stability.Metabolism-guided drug design In Vitro and In Silico Insights into sEH Inhibitors with Amide-Scaffold from the Leaves of Capsicum chinense Jacq

P2860

Q24616753-81F17732-F293-4C6E-9B4D-5308D223C795 Q24618018-29FC39BC-E15D-4598-92B3-9AE237B4CA6C Q27644661-E16C11BF-52CC-4015-AB18-5B90343B03BA Q27678172-79119333-45EB-4345-98FE-C342D18B795F Q27703977-0DB0F4C1-BDBB-4482-AEF8-819C7EF5B0AE Q29248913-EFB0DC5E-EAD3-4112-9FF0-898586CCF17B Q33744236-5E6CDBB0-CF5A-4A42-9856-2D5764AED558 Q34231319-BE3F8118-8D35-496E-A350-4B598E9A75BE Q34440084-63378712-4710-46FC-802B-233D68B9E2E6 Q36555388-CB293219-7495-4597-BDD8-48A333426A83 Q36784547-5658BF81-85CE-4FBB-9668-D4BE6ADD5B50 Q38698576-164128C9-4B10-4370-84A0-D4CA067B7277 Q38785907-4AD2A635-FD7B-42E5-8FE1-47F5A5511B10 Q39000644-3DB59A89-C1D5-4212-A5FA-8F160FEA8E6F Q41486228-12AD2D35-BC39-4600-A64C-7F87BC9ABA58 Q41821577-2A9154A1-7BF1-4024-B734-A094364CC199 Q41862863-26414A49-1982-4C96-AE32-13E561D7C16B Q42100360-FEFA6DFF-BB63-428E-8AD9-37504D06CEA2 Q47098164-F476466C-CA3E-4A32-A949-02EA8812A53A Q52642084-0E98271C-EDB6-4002-8167-7082A0977D9E Q56115898-7EE8F8A0-8B4D-4727-88DE-CDA9F4DE9AD2 Q58697605-885CF603-41B6-4398-A588-9B227BBC1B36

P2860

Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase

http://www.wikidata.org/entity/Q27657397

description

2009 nî lūn-bûn

@nan

2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2009年の論文

@ja

2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase

@ast

Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase

@en

Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase

@nl

type

label

Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase

@ast

Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase

@en

Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase

@nl

prefLabel

Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase

@ast

Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase

@en

Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase

@nl

P1433

Q27657397-9374BABF-6318-4952-8620-6CB9C94B2754

P1476

Q27657397-1458F43E-5EBC-4A5B-A927-873563F9A496

P2093

Q27657397-076D578B-B9E8-417C-B8C7-1E16221E2A38

Q27657397-093B9C3B-1BEF-41D9-8A59-EB110B7D39ED

Q27657397-227E7C45-B6C9-490B-8796-5D44CB05F3B1

Q27657397-2952298E-68E2-42EB-905A-53C769B67E93

Q27657397-5BE9FEEF-F7B6-45BE-A21B-48632256F5F3

Q27657397-69C12E02-80D8-4946-BE9C-A7B43F78C5A1

Q27657397-ABCF8B90-5BA6-4042-B5C4-1BE3E04C3A85

Q27657397-D87AB30E-7B2A-4DFB-A090-7E03309F36B6

Q27657397-F0A003EA-398F-41EF-ADE2-BA9B860CF67C

Q27657397-F101F9BE-45A9-4793-94D3-E967E0684BFF

P304

Q27657397-47197891-6626-482C-B6B9-56D400D03C40

P31

Q27657397-D3F51355-E98C-4F4C-867D-E585134D90A0

P356

Q27657397-FAE40FF4-87A9-4251-AB14-F78247B99670

P407

Q27657397-6AEA5588-2DFC-4624-A9CB-FD3027A37BAD

P433

Q27657397-E3DAA22E-BED0-41F7-BC8E-0128A06F9BBC

P478

Q27657397-F801842E-1281-4086-93D2-07CABE71ED91

P577

Q27657397-C2B9BA27-EFCF-44F1-8227-8B836AF2CC5B

P698

Q27657397-E66B152A-A669-4A0C-82C5-2CA9731B3519

P356

P1433

Journal of Medicinal Chemistry

P1476

Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase

@en

P2093

Alison Kukulka

http://www.w3.org/2001/XMLSchema#string

Anne B Eldrup

http://www.w3.org/2001/XMLSchema#string

Chuk C Man

http://www.w3.org/2001/XMLSchema#string

David Joseph

http://www.w3.org/2001/XMLSchema#string

Fariba Soleymanzadeh

http://www.w3.org/2001/XMLSchema#string

Ingo Muegge

http://www.w3.org/2001/XMLSchema#string

Keith McKellop

http://www.w3.org/2001/XMLSchema#string

Neil A Farrow

http://www.w3.org/2001/XMLSchema#string

Steven J Taylor

http://www.w3.org/2001/XMLSchema#string

Stéphane De Lombaert

http://www.w3.org/2001/XMLSchema#string

P304

5880-95

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1021/JM9005302

http://www.w3.org/2001/XMLSchema#string

P407

P433

19

http://www.w3.org/2001/XMLSchema#string

P478

52

http://www.w3.org/2001/XMLSchema#string

P577

2009-10-08T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

19746975

http://www.w3.org/2001/XMLSchema#string