1-(1-acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia
about
Discovery of inhibitors of soluble epoxide hydrolase: a target with multiple potential therapeutic indicationsFragment Screening of Soluble Epoxide Hydrolase for Lead Generation-Structure-Based Hit Evaluation and Chemistry ExplorationInside epoxyeicosatrienoic acids and cardiovascular diseasePharmacokinetics, pharmacodynamics and adverse event profile of GSK2256294, a novel soluble epoxide hydrolase inhibitorEpoxyeicosatrienoic acids and glucose homeostasis in mice and menGenetic variation in soluble epoxide hydrolase: association with outcome after aneurysmal subarachnoid hemorrhageThe 2014 Bernard B. Brodie award lecture-epoxide hydrolases: drug metabolism to therapeutics for chronic painStructure-based optimization of the piperazino-containing 1,3-disubstituted ureas affording sub-nanomolar inhibitors of soluble epoxide hydrolase.The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivativesEpoxyeicosatrienoic acids mediate insulin-mediated augmentation in skeletal muscle perfusion and blood volumeOccurrence of urea-based soluble epoxide hydrolase inhibitors from the plants in the order BrassicalesComparative efficacy of 3 soluble epoxide hydrolase inhibitors in rat neuropathic and inflammatory pain modelsPro-atherogenic role of smooth muscle Nox4-based NADPH oxidase.Design, synthesis and biological evaluation of 4-benzamidobenzoic Acid hydrazide derivatives as novel soluble epoxide hydrolase inhibitorsKey advances in antihypertensive treatment.Prevention of coronary artery disease: recent advances in the management of hypertension.Design, synthesis and evaluation of non-urea inhibitors of soluble epoxide hydrolase.Insight into the binding modes and inhibition mechanisms of adamantyl-based 1,3-disubstituted urea inhibitors in the active site of the human soluble epoxide hydrolase.Orally Available Soluble Epoxide Hydrolase/Phosphodiesterase 4 Dual Inhibitor Treats Inflammatory Pain.Synthesis, Characterization, and Evaluation for Antibacterial and Antifungal Activities of N-Heteroaryl Substituted Benzene Sulphonamides
P2860
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P2860
1-(1-acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
1-(1-acetyl-piperidin-4-yl)-3- ...... f hypertension and dysglycemia
@en
1-(1-acetyl-piperidin-4-yl)-3- ...... f hypertension and dysglycemia
@nl
type
label
1-(1-acetyl-piperidin-4-yl)-3- ...... f hypertension and dysglycemia
@en
1-(1-acetyl-piperidin-4-yl)-3- ...... f hypertension and dysglycemia
@nl
prefLabel
1-(1-acetyl-piperidin-4-yl)-3- ...... f hypertension and dysglycemia
@en
1-(1-acetyl-piperidin-4-yl)-3- ...... f hypertension and dysglycemia
@nl
P2093
P2860
P1476
1-(1-acetyl-piperidin-4-yl)-3- ...... f hypertension and dysglycemia
@en
P2093
Basker R Aavula
Bruce D Hammock
D Euan MacIntyre
Dinesh V Patel
Heather Kay Webb
James Sabry
Joanna Waszczuk
Jon Vincelette
Kathy White
P2860
P304
P356
10.1016/J.BMCL.2010.12.042
P407
P577
2010-12-13T00:00:00Z