Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a
about
Structural genomics of histone tail recognitionA chemical probe selectively inhibits G9a and GLP methyltransferase activity in cellsTargeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectivesFetal Alcohol Spectrum Disorder: Potential Role of Endocannabinoids SignalingSynthesis of lysine methyltransferase inhibitorsEpigenomics of leukemia: from mechanisms to therapeutic applicationsChemical probes of histone lysine methyltransferasesCurrent chemical biology approaches to interrogate protein methyltransferasesTrials with 'epigenetic' drugs: an updateAdding a Lysine Mimic in the Design of Potent Inhibitors of Histone Lysine MethyltransferasesSmall-Molecule Ligands of Methyl-Lysine Binding ProteinsAn Analog of BIX-01294 Selectively Inhibits a Family of Histone H3 Lysine 9 Jumonji DemethylasesThe emerging role of lysine methyltransferase SETD8 in human diseasesDiscovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8C-terminal domain of SMYD3 serves as a unique HSP90-regulated motif in oncogenesisStructure-guided design of fluorescent S-adenosylmethionine analogs for a high-throughput screen to target SAM-I riboswitch RNAsModulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectivesBiophysical characterization of recombinant proteins: a key to higher structural genomics successAccessing protein methyltransferase and demethylase enzymology using microfluidic capillary electrophoresisDiscovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies.NMDA receptor- and ERK-dependent histone methylation changes in the lateral amygdala bidirectionally regulate fear memory formation.Coordinated chromatin control: structural and functional linkage of DNA and histone methylation.Chemical and biochemical approaches in the study of histone methylation and demethylationMethods for Activity Analysis of the Proteins that Regulate Histone MethylationTR-FRET cellular assays for interrogating posttranslational modifications of histone H3.Fluorescence-based methods for screening writers and readers of histone methyl marks.Efficient hit-finding approaches for histone methyltransferases: the key parameters.Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines.Molecular insights on basal-like breast cancer.Perspectives on the discovery of small-molecule modulators for epigenetic processes.Current limitations and future opportunities for epigenetic therapies.Development of diaminoquinazoline histone lysine methyltransferase inhibitors as potent blood-stage antimalarial compoundsMicroscale thermophoresis quantifies biomolecular interactions under previously challenging conditionsAn orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparumEpigenetic drugs against cancer: an evolving landscape.Writing and rewriting the epigenetic code of cancer cells: from engineered proteins to small moleculesDynamics of histone lysine methylation: structures of methyl writers and erasersSmall-molecular modulators of cancer-associated epigenetic mechanisms.Structure-activity relationship studies of SETD8 inhibitors.
P2860
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P2860
Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Discovery of a 2,4-Diamino-7-a ...... e Lysine Methyltransferase G9a
@ast
Discovery of a 2,4-Diamino-7-a ...... e Lysine Methyltransferase G9a
@en
Discovery of a 2,4-Diamino-7-a ...... e Lysine Methyltransferase G9a
@nl
type
label
Discovery of a 2,4-Diamino-7-a ...... e Lysine Methyltransferase G9a
@ast
Discovery of a 2,4-Diamino-7-a ...... e Lysine Methyltransferase G9a
@en
Discovery of a 2,4-Diamino-7-a ...... e Lysine Methyltransferase G9a
@nl
prefLabel
Discovery of a 2,4-Diamino-7-a ...... e Lysine Methyltransferase G9a
@ast
Discovery of a 2,4-Diamino-7-a ...... e Lysine Methyltransferase G9a
@en
Discovery of a 2,4-Diamino-7-a ...... e Lysine Methyltransferase G9a
@nl
P2093
P2860
P50
P3181
P356
P1476
Discovery of a 2,4-Diamino-7-a ...... e Lysine Methyltransferase G9a
@en
P2093
Aiping Dong
Amy M Quinn
Dmitri B Kireev
Irene Chau
J Martin Herold
Stephen V Frye
P2860
P304
P3181
P356
10.1021/JM901543M
P407
P50
P577
2009-12-24T00:00:00Z