Structure and dynamics of NBD1 from CFTR characterized using crystallography and hydrogen/deuterium exchange mass spectrometry - Wikidata - awgldk - TriplyDB

Structure and dynamics of NBD1 from CFTR characterized using crystallography and hydrogen/deuterium exchange mass spectrometry

Structure and dynamics of NBD1 from CFTR characterized using crystallography and hydrogen/deuterium exchange mass spectrometry

http://www.wikidata.org/entity/Q27658358

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Mechanisms of CFTR Folding at the Endoplasmic Reticulum Molecular Chaperones as Targets to Circumvent the CFTR Defect in Cystic Fibrosis Requirements for Efficient Correction of ΔF508 CFTR Revealed by Analyses of Evolved Sequences EttA regulates translation by binding the ribosomal E site and restricting ribosome-tRNA dynamics The primary folding defect and rescue of ΔF508 CFTR emerge during translation of the mutant domain Changes in the Factor VIII C2 domain upon membrane binding determined by hydrogen-deuterium exchange MS.New insights into interactions between the nucleotide-binding domain of CFTR and keratin 8.An ambiguity principle for assigning protein structural domains Development of CFTR Structure Enhancing the Potency of F508del Correction: A Multi-Layer Combinational Approach to Drug Discovery for Cystic Fibrosis.Complement yourself: Transcomplementation rescues partially folded mutant proteins.Decoding F508del misfolding in cystic fibrosis.Restoration of domain folding and interdomain assembly by second-site suppressors of the DeltaF508 mutation in CFTR Applications of proteomic technologies for understanding the premature proteolysis of CFTR.Expanding the proteome: disordered and alternatively folded proteins.The cystic fibrosis-causing mutation deltaF508 affects multiple steps in cystic fibrosis transmembrane conductance regulator biogenesis.A chaperone trap contributes to the onset of cystic fibrosis.VX-809 corrects folding defects in cystic fibrosis transmembrane conductance regulator protein through action on membrane-spanning domain 1.Modeling the conformational changes underlying channel opening in CFTR Rational Coupled Dynamics Network Manipulation Rescues Disease-Relevant Mutant Cystic Fibrosis Transmembrane Conductance Regulator.Probing conformational rescue induced by a chemical corrector of F508del-cystic fibrosis transmembrane conductance regulator (CFTR) mutant.Phenotype-optimized sequence ensembles substantially improve prediction of disease-causing mutation in cystic fibrosis.Types and effects of protein variations.Dynamics of a bacterial multidrug ABC transporter in the inward- and outward-facing conformations Thermal instability of ΔF508 cystic fibrosis transmembrane conductance regulator (CFTR) channel function: protection by single suppressor mutations and inhibiting channel activity Transient sampling of aggregation-prone conformations causes pathogenic instability of a parkinsonian mutant of DJ-1 at physiological temperature.Molecular modelling and molecular dynamics of CFTR.Deletion of Phenylalanine 508 in the First Nucleotide-binding Domain of the Cystic Fibrosis Transmembrane Conductance Regulator Increases Conformational Exchange and Inhibits Dimerization.Combination of Correctors Rescue ΔF508-CFTR by Reducing Its Association with Hsp40 and Hsp27.A synonymous codon change alters the drug sensitivity of ΔF508 cystic fibrosis transmembrane conductance regulator.Non-native Conformers of Cystic Fibrosis Transmembrane Conductance Regulator NBD1 Are Recognized by Hsp27 and Conjugated to SUMO-2 for Degradation.Dynamics intrinsic to cystic fibrosis transmembrane conductance regulator function and stability Binding screen for cystic fibrosis transmembrane conductance regulator correctors finds new chemical matter and yields insights into cystic fibrosis therapeutic strategy CFTR: folding, misfolding and correcting the ΔF508 conformational defect.Mechanism-based corrector combination restores ΔF508-CFTR folding and function.Combating cystic fibrosis: in search for CF transmembrane conductance regulator (CFTR) modulators.Recent advances and new perspectives in targeting CFTR for therapy of cystic fibrosis and enterotoxin-induced secretory diarrheas.Functional Rescue of F508del-CFTR Using Small Molecule Correctors Cystic fibrosis transmembrane conductance regulator (ABCC7) structure Repairing mutated proteins--development of small molecules targeting defects in the cystic fibrosis transmembrane conductance regulator.

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Structure and dynamics of NBD1 from CFTR characterized using crystallography and hydrogen/deuterium exchange mass spectrometry

http://www.wikidata.org/entity/Q27658358

description

2010 nî lūn-bûn

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2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2010 թվականի փետրվարին հրատարակված գիտական հոդված

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2010年の論文

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Structure and dynamics of NBD1 ...... ium exchange mass spectrometry

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