Functional Rescue of F508del-CFTR Using Small Molecule Correctors
about
Regulatory Crosstalk by Protein Kinases on CFTR Trafficking and Activity.Recent developments in the use of differential scanning fluorometry in protein and small molecule discovery and characterizationThe cystic fibrosis transmembrane conductance regulator (CFTR) and its stabilityLMTK2-mediated phosphorylation regulates CFTR endocytosis in human airway epithelial cells.Phenotypic profiling of CFTR modulators in patient-derived respiratory epithelia.Stabilizing rescued surface-localized δf508 CFTR by potentiation of its interaction with Na(+)/H(+) exchanger regulatory factor 1.Tgf-β1 inhibits Cftr biogenesis and prevents functional rescue of ΔF508-Cftr in primary differentiated human bronchial epithelial cells.Calpain inhibition promotes the rescue of F(508)del-CFTR in PBMC from cystic fibrosis patients.Rescue of functional CFTR channels in cystic fibrosis: a dramatic multivalent effect using iminosugar cluster-based correctors.Targeted Integration of a Super-Exon into the CFTR Locus Leads to Functional Correction of a Cystic Fibrosis Cell Line Model.c-Cbl reduces stability of rescued ∆F508-CFTR in human airway epithelial cells: Implications for cystic fibrosis treatment.Inside job: ligand-receptor pharmacology beneath the plasma membrane.Carbamazepine as a novel small molecule corrector of trafficking-impaired ATP-sensitive potassium channels identified in congenital hyperinsulinism.Bone disease in cystic fibrosis: new pathogenic insights opening novel therapies.Orkambi® and amplifier co-therapy improves function from a rare CFTR mutation in gene-edited cells and patient tissue.Biophysical Approaches Facilitate Computational Drug Discovery for ATP-Binding Cassette Proteins.Facilitating Structure-Function Studies of CFTR Modulator Sites with Efficiencies in Mutagenesis and Functional Screening.Thermal unfolding simulations of NBD1 domain variants reveal structural motifs associated with the impaired folding of F508del-CFTR.Directed differentiation of cholangiocytes from human pluripotent stem cells.Molecular Mechanism of Action of Trimethylangelicin Derivatives as CFTR Modulators.
P2860
Q26770258-6D466B0A-3004-4EF3-9F4C-C24FB5939C01Q26996528-A4819497-CF15-4155-90D5-A537589ABB97Q30394029-A2758913-FBE8-47E1-8C23-533F04882371Q30412916-9F3D601D-66E9-4F48-9341-E679C7C9B47FQ33825789-8C0A2CAF-ABBB-4285-A9D2-AFA313C9CAB7Q33843016-B4D4233A-6C2E-42CC-BBA3-6E92BA02A5FBQ34721046-78517F06-098D-478E-A137-93F52DBB3A3DQ34778832-29E9C0BC-046C-4F03-B18C-BCB3F9812A2AQ34987828-A9715E9D-7ACA-46E8-85E5-95DEE60988E3Q36104186-F3132FCC-16E0-4163-B057-A5CCF51A67C6Q36721425-64BBED84-C2AE-4774-A150-D34AB944082BQ36989788-1214B762-9D85-4926-B079-37C5E03FCEA3Q37175099-365E9540-4430-45C6-972B-6A2D8415DA2BQ38598049-1B564FE8-1A4C-42EA-BF4C-06041441806DQ38698489-04629F1B-8CC5-4C5D-8E8C-AFC9FAB1318AQ38837398-3E92F008-57CE-4128-9D26-1B67BE843A10Q38962286-D43CC08A-2BAA-4435-A276-AE45AC3E248BQ39647261-9A39DBD1-5583-4127-BC1F-629DE0DDE979Q52931552-81DD2807-0764-4D92-B295-C22E60D686ABQ55691070-87872898-0C51-45B2-85A6-6B509806D5EE
P2860
Functional Rescue of F508del-CFTR Using Small Molecule Correctors
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Functional Rescue of F508del-CFTR Using Small Molecule Correctors
@en
type
label
Functional Rescue of F508del-CFTR Using Small Molecule Correctors
@en
prefLabel
Functional Rescue of F508del-CFTR Using Small Molecule Correctors
@en
P2093
P2860
P356
P1476
Functional Rescue of F508del-CFTR Using Small Molecule Correctors
@en
P2093
Christine E Bear
Paul D W Eckford
Stan Pasyk
Stephanie Chin
P2860
P356
10.3389/FPHAR.2012.00160
P577
2012-09-26T00:00:00Z