High-throughput screening to identify inhibitors which stabilize inactive kinase conformations in p38alpha
about
Exploration of type II binding mode: A privileged approach for kinase inhibitor focused drug discovery?Identification of type-II inhibitors using kinase structuresThe rational design of specific peptide inhibitor against p38α MAPK at allosteric-site: a therapeutic modality for HNSCCThe design and application of target-focused compound libraries.Multidimensional profiling of CSF1R screening hits and inhibitors: assessing cellular activity, target residence time, and selectivity in a higher throughput way.Oxidative condensations to form benzimidazole-substituted potassium organotrifluoroborates.Fluorescent-responsive synthetic C1b domains of protein kinase Cδ as reporters of specific high-affinity ligand bindingFluorescent biosensors for high throughput screening of protein kinase inhibitors.p38α MAPK and Type I Inhibitors: Binding Site Analysis and Use of Target Ensembles in Virtual Screening.Light-assisted small-molecule screening against protein kinases.Monitoring Conformational Changes in the Receptor Tyrosine Kinase EGFR.Discovery of allosteric modulators for GABAA receptors by ligand-directed chemistry.Optimized 4,5-Diarylimidazoles as Potent/Selective Inhibitors of Protein Kinase CK1δ and Their Structural Relation to p38α MAPK.Mutations of FLT3/ITD confer resistance to multiple tyrosine kinase inhibitors.Fluorescent Reporters and Biosensors for Probing the Dynamic Behavior of Protein KinasesTinkering outside the kinase ATP box: allosteric (type IV) and bivalent (type V) inhibitors of protein kinases.A Comprehensive Structural Overview of p38α MAPK in Complex with Type I Inhibitors.Characterization of interactions and pharmacophore development for DFG-out inhibitors to RET tyrosine kinase.Structure-based design, synthesis and crystallization of 2-arylquinazolines as lipid pocket ligands of p38α MAPK.Interaction investigations of HipA binding to HipB dimer and HipB dimer + DNA complex: a molecular dynamics simulation study.Structure- and ligand-based drug design of novel p38-alpha MAPK inhibitors in the fight against the Alzheimer's disease.Mechanism of kinase inactivation and nonbinding of FRATide to GSK3β due to K85M mutation: molecular dynamics simulation and normal mode analysis.Thiazoles in Peptides and Peptidomimetics
P2860
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P2860
High-throughput screening to identify inhibitors which stabilize inactive kinase conformations in p38alpha
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
High-throughput screening to i ...... nase conformations in p38alpha
@ast
High-throughput screening to i ...... nase conformations in p38alpha
@en
High-throughput screening to i ...... nase conformations in p38alpha
@nl
type
label
High-throughput screening to i ...... nase conformations in p38alpha
@ast
High-throughput screening to i ...... nase conformations in p38alpha
@en
High-throughput screening to i ...... nase conformations in p38alpha
@nl
prefLabel
High-throughput screening to i ...... nase conformations in p38alpha
@ast
High-throughput screening to i ...... nase conformations in p38alpha
@en
High-throughput screening to i ...... nase conformations in p38alpha
@nl
P2093
P356
P1476
High-throughput screening to i ...... nase conformations in p38alpha
@en
P2093
Alexander Wolf
Armin Robubi
Beate Aust
Christian Grütter
Daniel Rauh
Jeffrey R Simard
Matthias Rabiller
Sabine Klüter
Sabine Wulfert
Vijaykumar Pawar
P304
P356
10.1021/JA907795Q
P407
P577
2009-12-30T00:00:00Z