Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats.
about
Crystallization and preliminary analysis of crystals of the 24-meric hemocyanin of the emperor scorpion (Pandinus imperator)Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexesHelix unwinding and base flipping enable human MTERF1 to terminate mitochondrial transcriptionStructural characterization of filaments formed by human Xrcc4-Cernunnos/XLF complex involved in nonhomologous DNA end-joiningATR-mediated regulation of nuclear and cellular plasticityDNA repair targeted therapy: The past or future of cancer treatment?Chemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promisingDNA-PK: a dynamic enzyme in a versatile DSB repair pathwayTor forms a dimer through an N-terminal helical solenoid with a complex topology.The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation.BCL::Fold--de novo prediction of complex and large protein topologies by assembly of secondary structure elementsAn unprecedented nucleic acid capture mechanism for excision of DNA damageXRCC4 Protein Interactions with XRCC4-like Factor (XLF) Create an Extended Grooved Scaffold for DNA Ligation and Double Strand Break RepairNon-homologous end-joining partners in a helical dance: structural studies of XLF-XRCC4 interactionsCrystal structure of Cex1p reveals the mechanism of tRNA trafficking between nucleus and cytoplasmmTOR kinase structure, mechanism and regulationArchitecture of human mTOR complex 1The C-terminal residues of Saccharomyces cerevisiae Mec1 are required for its localization, stability, and function.The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosisRpn1 and Rpn2 coordinate ubiquitin processing factors at proteasomeMutation of serine 1333 in the ATR HEAT repeats creates a hyperactive kinaseTrp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signalingThe Dimeric Architecture of Checkpoint Kinases Mec1ATR and Tel1ATM Reveal a Common Structural OrganizationNanospray HX-MS configuration for structural interrogation of large protein systems.EM-fold: de novo atomic-detail protein structure determination from medium-resolution density maps.One small step for Mot1; one giant leap for other Swi2/Snf2 enzymes?Two-Stage Synapsis of DNA Ends during Non-homologous End Joining.New diagnosis of atypical ataxia-telangiectasia in a 17-year-old boy with T-cell acute lymphoblastic leukemia and a novel ATM mutationNonhomologous end joining: a good solution for bad endsA method for systematic mapping of protein lysine methylation identifies functions for HP1β in DNA damage response.DNA-PKcs, Allostery, and DNA Double-Strand Break Repair: Defining the Structure and Setting the Stage.Kinase activity profiling of pneumococcal pneumoniaThe DNA damage response kinases DNA-dependent protein kinase (DNA-PK) and ataxia telangiectasia mutated (ATM) Are stimulated by bulky adduct-containing DNA.Structural insights into NHEJ: building up an integrated picture of the dynamic DSB repair super complex, one component and interaction at a timeStructural dynamics in DNA damage signaling and repairCoincident In Vitro Analysis of DNA-PK-Dependent and -Independent Nonhomologous End Joining.Targeting nonhomologous end-joining through epidermal growth factor receptor inhibition: rationale and strategies for radiosensitization.Loss of nonsense mediated decay suppresses mutations in Saccharomyces cerevisiae TRA1Interaction between HIV-1 Tat and DNA-PKcs modulates HIV transcription and class switch recombination.The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8.
P2860
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P2860
Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats.
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats
@nl
Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats.
@ast
Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats.
@en
type
label
Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats
@nl
Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats.
@ast
Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats.
@en
prefLabel
Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats
@nl
Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats.
@ast
Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats.
@en
P2860
P3181
P356
P1433
P1476
Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats.
@en
P2093
Bancinyane L Sibanda
P2860
P2888
P304
P3181
P356
10.1038/NATURE08648
P407
P577
2009-12-20T00:00:00Z
P5875
P6179
1035559188