Mapping of protein-protein interactions within the DNA-dependent protein kinase complex
about
Structural model of full-length human Ku70-Ku80 heterodimer and its recognition of DNA and DNA-PKcsSubnuclear localization of Ku protein: functional association with RNA polymerase II elongation sites.Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminusDynamics of DNA damage response proteins at DNA breaks: a focus on protein modificationsProkaryotic homologs of the eukaryotic DNA-end-binding protein Ku, novel domains in the Ku protein and prediction of a prokaryotic double-strand break repair systemRecruitment of Saccharomyces cerevisiae Dnl4-Lif1 complex to a double-strand break requires interactions with Yku80 and the Xrs2 FHA domainDNA-PK: a dynamic enzyme in a versatile DSB repair pathwayCrystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats.Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase.Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair.DNA-PKcs dependence of Artemis endonucleolytic activity, differences between hairpins and 5' or 3' overhangs.Separation-of-function mutants of yeast Ku80 reveal a Yku80p-Sir4p interaction involved in telomeric silencing.A short C-terminal domain of Yku70p is essential for telomere maintenance.The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosisIdentification of bacterial homologues of the Ku DNA repair proteinsWerner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylationNon-homologous end-joining, a sticky affairRole of non-homologous end joining in V(D)J recombinationThe human DNA ends proteome uncovers an unexpected entanglement of functional pathwaysConserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damageKinetic analysis of the Ku-DNA binding activity reveals a redox-dependent alteration in protein structure that stimulates dissociation of the Ku-DNA complexRequirements for the nucleolytic processing of DNA ends by the Werner syndrome protein-Ku70/80 complex.Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex.Nonhomologous end joining: a good solution for bad endsATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.DNA-PKcs, Allostery, and DNA Double-Strand Break Repair: Defining the Structure and Setting the Stage.Structural insights into NHEJ: building up an integrated picture of the dynamic DSB repair super complex, one component and interaction at a timeMycobacterium tuberculosis Ku can bind to nuclear DNA damage and sensitize mammalian cells to bleomycin sulfate.The DNA-damage response: new molecular insights and new approaches to cancer therapyNon-homologous end joining: Common interaction sites and exchange of multiple factors in the DNA repair process.Granzyme A, which causes single-stranded DNA damage, targets the double-strand break repair protein Ku70.A structural model for regulation of NHEJ by DNA-PKcs autophosphorylationIdentification and functional characterization of a Ku-binding motif in aprataxin polynucleotide kinase/phosphatase-like factor (APLF)Ku80 removal from DNA through double strand break-induced ubiquitylation.Recognition and repair of chemically heterogeneous structures at DNA endsChoosing the right path: does DNA-PK help make the decision?Recognition of DNA Termini by the C-Terminal Region of the Ku80 and the DNA-Dependent Protein Kinase Catalytic SubunitThe role of the non-homologous end-joining pathway in lymphocyte development.The life and death of DNA-PK.Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery.
P2860
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P2860
Mapping of protein-protein interactions within the DNA-dependent protein kinase complex
description
1999 nî lūn-bûn
@nan
1999 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Mapping of protein-protein interactions within the DNA-dependent protein kinase complex
@ast
Mapping of protein-protein interactions within the DNA-dependent protein kinase complex
@en
Mapping of protein-protein interactions within the DNA-dependent protein kinase complex
@nl
type
label
Mapping of protein-protein interactions within the DNA-dependent protein kinase complex
@ast
Mapping of protein-protein interactions within the DNA-dependent protein kinase complex
@en
Mapping of protein-protein interactions within the DNA-dependent protein kinase complex
@nl
prefLabel
Mapping of protein-protein interactions within the DNA-dependent protein kinase complex
@ast
Mapping of protein-protein interactions within the DNA-dependent protein kinase complex
@en
Mapping of protein-protein interactions within the DNA-dependent protein kinase complex
@nl
P2860
P3181
P356
P1476
Mapping of protein-protein interactions within the DNA-dependent protein kinase complex
@en
P2093
S P Jackson
P2860
P304
P3181
P356
10.1093/NAR/27.17.3494
P407
P50
P577
1999-09-01T00:00:00Z