Molecular basis of factor IXa recognition by heparin-activated antithrombin revealed by a 1.7-A structure of the ternary complex
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Structural and Functional Characterization of a Highly Specific Serpin in the Insect Innate ImmunityA structure-derived snap-trap mechanism of a multispecific serpin from the dysbiotic human oral microbiome.Defining a Novel Role for the Coxsackievirus and Adenovirus Receptor in Human Adenovirus Serotype 5 Transduction In Vitro in the Presence of Mouse Serum.Characterization of a novel serine protease inhibitor gene from a marine metagenome.Correlation of factor IXa subsite modulations with effects on substrate discrimination.Role of the residues of the 39-loop in determining the substrate and inhibitor specificity of factor IXa.The regulation of factor IXa by supersulfated low molecular weight heparin.Conformational activation of antithrombin by heparin involves an altered exosite interaction with protease.Heparan sulfate proteoglycans mediate factor XIIa binding to the cell surfaceDesign and prediction of new anticoagulants as a selective Factor IXa inhibitor via three-dimensional quantitative structure-property relationships of amidinobenzothiophene derivatives.Crystal Structure of the Michaelis Complex between Tissue-type Plasminogen Activator and Plasminogen Activators Inhibitor-1.Saturation Mutagenesis of the Antithrombin Reactive Center Loop P14 Residue Supports a Three-step Mechanism of Heparin Allosteric Activation Involving Intermediate and Fully Activated StatesResidues of the 39-loop restrict the plasma inhibitor specificity of factor IXa.The allosteric mechanism of activation of antithrombin as an inhibitor of factor IXa and factor Xa: heparin-independent full activation through mutations adjacent to helix D.Molecular mechanisms of antithrombin-heparin regulation of blood clotting proteinases. A paradigm for understanding proteinase regulation by serpin family protein proteinase inhibitors.Antithrombin deficiency and its laboratory diagnosis.The importance of coagulation factors binding to adenovirus: historical perspectives and implications for gene delivery.Molecular Basis of Chemokine CXCL5-Glycosaminoglycan InteractionsConformational selection of the AGA*IA(M) heparin pentasaccharide when bound to the fibroblast growth factor receptor.Kinetic evidence that allosteric activation of antithrombin by heparin is mediated by two sequential conformational changes.Inhibitory serpins. New insights into their folding, polymerization, regulation and clearance.Improving resolution in multidimensional NMR using random quadrature detection with compressed sensing reconstruction.Approaches to prevent bleeding associated with anticoagulants: current status and recent developments.Engineered factor Xa variants retain procoagulant activity independent of direct factor Xa inhibitors.Molecular contortionism - on the physical limits of serpin 'loop-sheet' polymers.1.45 Å resolution structure of SRPN18 from the malaria vector Anopheles gambiae.Selective disruption of heparin and antithrombin-mediated regulation of human factor IX.The timeline of corona formation around silica nanocarriers highlights the role of the protein interactome.Dynamic properties of the native free antithrombin from molecular dynamics simulations: computational evidence for solvent- exposed Arg393 side chain.
P2860
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P2860
Molecular basis of factor IXa recognition by heparin-activated antithrombin revealed by a 1.7-A structure of the ternary complex
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2010 nî lūn-bûn
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2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年論文
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2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
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2010年论文
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name
Molecular basis of factor IXa ...... ructure of the ternary complex
@ast
Molecular basis of factor IXa ...... ructure of the ternary complex
@en
Molecular basis of factor IXa ...... ructure of the ternary complex
@nl
type
label
Molecular basis of factor IXa ...... ructure of the ternary complex
@ast
Molecular basis of factor IXa ...... ructure of the ternary complex
@en
Molecular basis of factor IXa ...... ructure of the ternary complex
@nl
prefLabel
Molecular basis of factor IXa ...... ructure of the ternary complex
@ast
Molecular basis of factor IXa ...... ructure of the ternary complex
@en
Molecular basis of factor IXa ...... ructure of the ternary complex
@nl
P2093
P2860
P356
P1476
Molecular basis of factor IXa ...... ructure of the ternary complex
@en
P2093
Daniel J D Johnson
James A Huntington
Jonathan Langdown
P2860
P304
P356
10.1073/PNAS.0910144107
P407
P577
2010-01-12T00:00:00Z