Conformational activation of antithrombin by heparin involves an altered exosite interaction with protease.
about
Saturation Mutagenesis of the Antithrombin Reactive Center Loop P14 Residue Supports a Three-step Mechanism of Heparin Allosteric Activation Involving Intermediate and Fully Activated StatesInhibitory serpins. New insights into their folding, polymerization, regulation and clearance.Approaches to prevent bleeding associated with anticoagulants: current status and recent developments.A novel antithrombin domain dictates the journey's end of a proteinase.Disease-causing mutations in the serpin antithrombin reveal a key domain critical for inhibiting protease activities.Antithrombin conformational modulation by D-myo-inositol 3,4,5,6-tetrakisphosphate (TMI), a novel scaffold for the development of antithrombotic agents.Recurrent mutations in a SERPINC1 hotspot associate with venous thrombosis without apparent antithrombin deficiency.A rapid pro-hemostatic approach to overcome direct oral anticoagulants.
P2860
Q36301206-E6381C49-218C-468D-9ED4-B9ED99011657Q38912052-AB7C2A03-9415-47B0-8EDD-3E57372E68AAQ39456319-64E20686-75E9-4A20-8203-15376F697E3EQ42070359-9CAC5797-1021-40EA-A0BF-AB19EC66C9FDQ42224032-07C18EC2-F692-402D-A062-C36367244324Q47316356-9D6E67C9-A095-47BF-B097-E84301F1EB89Q49252439-732A7E0B-B7C0-42EC-83A7-BB960663E453Q51618025-1CB0CF05-C68E-40F4-B892-A557EAAF2C44
P2860
Conformational activation of antithrombin by heparin involves an altered exosite interaction with protease.
description
2014 nî lūn-bûn
@nan
2014 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年学术文章
@wuu
2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
@yue
name
Conformational activation of a ...... ite interaction with protease.
@ast
Conformational activation of a ...... ite interaction with protease.
@en
Conformational activation of a ...... ite interaction with protease.
@nl
type
label
Conformational activation of a ...... ite interaction with protease.
@ast
Conformational activation of a ...... ite interaction with protease.
@en
Conformational activation of a ...... ite interaction with protease.
@nl
prefLabel
Conformational activation of a ...... ite interaction with protease.
@ast
Conformational activation of a ...... ite interaction with protease.
@en
Conformational activation of a ...... ite interaction with protease.
@nl
P2093
P2860
P356
P1476
Conformational activation of a ...... ite interaction with protease.
@en
P2093
Alireza R Rezaie
Gonzalo Izaguirre
Peter G W Gettins
Richard Swanson
Steven T Olson
P2860
P304
34049-34064
P356
10.1074/JBC.M114.611707
P407
P50
P577
2014-10-20T00:00:00Z