The intrinsic protein flexibility of endogenous protease inhibitor TIMP-1 controls its binding interface and affects its function
about
Lumican: a new inhibitor of matrix metalloproteinase-14 activityAncylostoma ceylanicum Excretory–Secretory Protein 2 Adopts a Netrin-Like Fold and Defines a Novel Family of Nematode ProteinsAntibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potentialMatrix Metalloproteinase-10 (MMP-10) Interaction with Tissue Inhibitors of Metalloproteinases TIMP-1 and TIMP-2: BINDING STUDIES AND CRYSTAL STRUCTUREMatrix Metalloproteinase-10/TIMP-2 Structure and Analyses Define Conserved Core Interactions and Diverse Exosite Interactions in MMP/TIMP ComplexesAffinity- and specificity-enhancing mutations are frequent in multispecific interactions between TIMP2 and MMPsIntrinsic dynamics study identifies two amino acids of TIMP-1 critical for its LRP-1-mediated endocytosis in neurons.Phage display of tissue inhibitor of metalloproteinases-2 (TIMP-2): identification of selective inhibitors of collagenase-1 (metalloproteinase 1 (MMP-1))TIMP-1 induces an EMT-like phenotypic conversion in MDCK cells independent of its MMP-inhibitory domain.Enzymatic turnover of macromolecules generates long-lasting protein-water-coupled motions beyond reaction steady stateDynamic interdomain interactions contribute to the inhibition of matrix metalloproteinases by tissue inhibitors of metalloproteinases.Phosphoramidate-based peptidomimetic inhibitors of membrane type-1 matrix metalloproteinaseCorrelated structural kinetics and retarded solvent dynamics at the metalloprotease active siteMatrix metalloproteinases as breast cancer drivers and therapeutic targets.Peptide-based selective inhibitors of matrix metalloproteinase-mediated activitiesThermodynamic Basis of Selectivity in the Interactions of Tissue Inhibitors of Metalloproteinases N-domains with Matrix Metalloproteinases-1, -3, and -14.Bilayer Membrane Modulation of Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) Structure and Proteolytic Activity.Dissection of the human multipotent adult progenitor cell secretome by proteomic analysis.Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression.Structural Studies of Matrix Metalloproteinase by X-Ray Diffraction.Metalloproteinases as mediators of inflammation and the eyes: molecular genetic underpinnings governing ocular pathophysiologyStrategic targeting of multiple water-mediated interactions: a concise and rational structure-based design approach to potent and selective MMP-13 inhibitorsCrystallization and preliminary X-ray crystallographic analysis of the catalytic domain of membrane type 1 matrix metalloproteinase.Therapeutic Potential of Matrix Metalloproteinase Inhibition in Breast Cancer.Recent opportunities in matrix metalloproteinase inhibitor drug design for cancer.Solvent water interactions within the active site of the membrane type I matrix metalloproteinase.Development of High Affinity and High Specificity Inhibitors of Matrix Metalloproteinase 14 through Computational Design and Directed Evolution.Converting a broad matrix metalloproteinase family inhibitor into a specific inhibitor of MMP-9 and MMP-14.Combinatorial engineering of N-TIMP2 variants that selectively inhibit MMP9 and MMP14 function in the cellThe selectivity of galardin and an azasugar-based hydroxamate compound for human matrix metalloproteases and bacterial metalloproteases
P2860
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P2860
The intrinsic protein flexibility of endogenous protease inhibitor TIMP-1 controls its binding interface and affects its function
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The intrinsic protein flexibil ...... rface and affects its function
@ast
The intrinsic protein flexibil ...... rface and affects its function
@en
The intrinsic protein flexibil ...... rface and affects its function
@nl
type
label
The intrinsic protein flexibil ...... rface and affects its function
@ast
The intrinsic protein flexibil ...... rface and affects its function
@en
The intrinsic protein flexibil ...... rface and affects its function
@nl
prefLabel
The intrinsic protein flexibil ...... rface and affects its function
@ast
The intrinsic protein flexibil ...... rface and affects its function
@en
The intrinsic protein flexibil ...... rface and affects its function
@nl
P2093
P3181
P356
P1433
P1476
The intrinsic protein flexibil ...... rface and affects its function
@en
P2093
Gillian Murphy
Meng-Huee Lee
Moran Grossman
Yaakov Levy
P304
P3181
P356
10.1021/BI902141X
P407
P577
2010-07-01T00:00:00Z