Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1 - Wikidata - awgldk - TriplyDB

Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1

Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1

http://www.wikidata.org/entity/Q27664093

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Crystal structure of triple-BRCT-domain of ECT2 and insights into the binding characteristics to CYK-4 Functional Evolution of BRCT Domains from Binding DNA to Protein BRCT domains: easy as one, two, three TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive Hematopoiesis Structure of C-terminal Tandem BRCT Repeats of Rtt107 Protein Reveals Critical Role in Interaction with Phosphorylated Histone H2A during DNA Damage Repair Structural Insights into Recognition of MDC1 by TopBP1 in DNA Replication Checkpoint Control Phosphorylation-Dependent Assembly and Coordination of the DNA Damage Checkpoint Apparatus by Rad4TopBP1 Efficient initiation of DNA replication in eukaryotes requires Dpb11/TopBP1-GINS interaction Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitment Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response BRCT domains: A little more than kin, and less than kind Tousled-like kinase-dependent phosphorylation of Rad9 plays a role in cell cycle progression and G2/M checkpoint exit.TopBP1 mediates mutant p53 gain of function through NF-Y and p63/p73.TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity.Direct Binding to Replication Protein A (RPA)-coated Single-stranded DNA Allows Recruitment of the ATR Activator TopBP1 to Sites of DNA Damage.The α2 helix in the DNA ligase IV BRCT-1 domain is required for targeted degradation of ligase IV during adenovirus infection.The C-terminal 20 Amino Acids of Drosophila Topoisomerase 2 Are Required for Binding to a BRCA1 C Terminus (BRCT) Domain-containing Protein, Mus101, and Fidelity of DNA Segregation TopBP1 contributes to the chemoresistance in non-small cell lung cancer through upregulation of p53 Akt switches TopBP1 function from checkpoint activation to transcriptional regulation through phosphoserine binding-mediated oligomerization.Helicase activation and establishment of replication forks at chromosomal origins of replication.Eukaryotic DNA damage checkpoint activation in response to double-strand breaks.Switch on the engine: how the eukaryotic replicative helicase MCM2-7 becomes activated.TopBP1-mediated DNA processing during mitosis.NONO regulates the intra-S-phase checkpoint in response to UV radiation.Multi-BRCT scaffolds use distinct strategies to support genome maintenance.A role for the MRN complex in ATR activation via TOPBP1 recruitment.Poly-gene fusion transcripts and chromothripsis in prostate cancer.The c.*229C > T gene polymorphism in 3'UTR region of the topoisomerase IIβ binding protein 1 gene and LOH in BRCA1/2 regions and their effect on the risk and progression of human laryngeal carcinoma.A cell cycle-regulated Slx4-Dpb11 complex promotes the resolution of DNA repair intermediates linked to stalled replication.Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain to Interrupt BRCA1-Dependent Signaling.

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Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1

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2011 nî lūn-bûn

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2011 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2011 թվականի հունվարին հրատարակված գիտական հոդված

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Antony W Oliver

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Laurence H Pearl

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Mathieu Rappas

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Characterization of the interaction between the human DNA topoisomerase IIbeta-binding protein 1 (TopBP1) and the cell division cycle 45 (Cdc45) protein

The BRCT domain is a phospho-protein binding domain

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

Regulation of TopBP1 oligomerization by Akt/PKB for cell survival

Crystal structure of the human rad9-hus1-rad1 clamp

Specific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNK

A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage

A DNA-topoisomerase-II-binding protein with eight repeating regions similar to DNA-repair enzymes and to a cell-cycle regulator

Structure of an XRCC1 BRCT domain: a new protein-protein interaction module

Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro

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