TopBP1 mediates mutant p53 gain of function through NF-Y and p63/p73.
about
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasionOncogenic Intra-p53 Family Member Interactions in Human CancersMutant p53: One, No One, and One Hundred ThousandThe rebel angel: mutant p53 as the driving oncogene in breast cancer.Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion.Characteristics and survival of patients with advanced cancer and p53 mutations.Pla2g16 phospholipase mediates gain-of-function activities of mutant p53.Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapyA mutant p53/let-7i-axis-regulated gene network drives cell migration, invasion and metastasis.Gain of function mutant p53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expressionMutant p53: one name, many proteins.An interaction between human papillomavirus 16 E2 and TopBP1 is required for optimum viral DNA replication and episomal genome establishmentTargeting mutant p53 by a SIRT1 activator YK-3-237 inhibits the proliferation of triple-negative breast cancer cellsThe consequence of oncomorphic TP53 mutations in ovarian cancer.Akt switches TopBP1 function from checkpoint activation to transcriptional regulation through phosphoserine binding-mediated oligomerization.Ovarian tumour growth is characterized by mevalonate pathway gene signature in an orthotopic, syngeneic model of epithelial ovarian cancer.YAP enhances the pro-proliferative transcriptional activity of mutant p53 proteins.The activating transcription factor 3 protein suppresses the oncogenic function of mutant p53 proteins.Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor β signalingThe TP73 complex network: ready for clinical translation in cancer?TP53 mutants in the tower of babel of cancer progression.Mutant p53 in cancer: new functions and therapeutic opportunities.Unravelling mechanisms of p53-mediated tumour suppression.Battle against cancer: an everlasting saga of p53.Mutant p53 upregulates alpha-1 antitrypsin expression and promotes invasion in lung cancer.ID4 regulates transcriptional activity of wild type and mutant p53 via K373 acetylationMutant p53 perturbs DNA replication checkpoint control through TopBP1 and Treslin.Gain-of-function p53 activates multiple signaling pathways to induce oncogenicity in lung cancer cells.Levels of the E2 interacting protein TopBP1 modulate papillomavirus maintenance stage replication.Regulation of human genome expression and RNA splicing by human papillomavirus 16 E2 protein.Transcriptional Regulation by Wild-Type and Cancer-Related Mutant Forms of p53.Mutant p53 regulates Dicer through p63-dependent and -independent mechanisms to promote an invasive phenotype.Functions of TAp63 and p53 in restraining the development of metastatic cancer.The Deacetylase SIRT1 Regulates the Replication Properties of Human Papillomavirus 16 E1 and E2.p53-R273H upregulates neuropilin-2 to promote cell mobility and tumor metastasisThe c.*229C > T gene polymorphism in 3'UTR region of the topoisomerase IIβ binding protein 1 gene and LOH in BRCA1/2 regions and their effect on the risk and progression of human laryngeal carcinoma.Why Human Papillomaviruses Activate the DNA Damage Response (DDR) and How Cellular and Viral Replication Persists in the Presence of DDR Signaling.A rare DNA contact mutation in cancer confers p53 gain-of-function and tumor cell survival via TNFAIP8 induction.Mutant p53 partners in crime.Li-Fraumeni Syndrome Disease Model: A Platform to Develop Precision Cancer Therapy Targeting Oncogenic p53.
P2860
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P2860
TopBP1 mediates mutant p53 gain of function through NF-Y and p63/p73.
description
2011 nî lūn-bûn
@nan
2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
TopBP1 mediates mutant p53 gain of function through NF-Y and p63/p73.
@ast
TopBP1 mediates mutant p53 gain of function through NF-Y and p63/p73.
@en
type
label
TopBP1 mediates mutant p53 gain of function through NF-Y and p63/p73.
@ast
TopBP1 mediates mutant p53 gain of function through NF-Y and p63/p73.
@en
prefLabel
TopBP1 mediates mutant p53 gain of function through NF-Y and p63/p73.
@ast
TopBP1 mediates mutant p53 gain of function through NF-Y and p63/p73.
@en
P2093
P2860
P356
P1476
TopBP1 mediates mutant p53 gain of function through NF-Y and p63/p73.
@en
P2093
Shiyun Ling
Weei-Chin Lin
P2860
P304
P356
10.1128/MCB.05574-11
P407
P577
2011-09-19T00:00:00Z