Essential structural requirements for specific recognition of HIV TAR RNA by peptide mimetics of Tat protein
about
A Small-Molecule Probe Induces a Conformation in HIV TAR RNA Capable of Binding Drug-Like FragmentsA novel small-molecule binds to the influenza A virus RNA promoter and inhibits viral replicationApproaches to Validate and Manipulate RNA Targets with Small Molecules in CellsConstraining cyclic peptides to mimic protein structure motifs.The crystal structure of the 5΄ functional domain of the transcription riboregulator 7SK.Methods to enable the design of bioactive small molecules targeting RNA.Efficient in silico exploration of RNA interhelical conformations using Euler angles and WExploreSpecific ion effects on macromolecular interactions in Escherichia coli extracts.On the Applicability of Elastic Network Models for the Study of RNA CUG Trinucleotide Repeat Overexpansion.Impact of Tat Genetic Variation on HIV-1 DiseaseA Macrocyclic Peptide Ligand Binds the Oncogenic MicroRNA-21 Precursor and Suppresses Dicer Processing.Modulating RNA Alignment Using Directional Dynamic Kinks: Application in Determining an Atomic-Resolution Ensemble for a Hairpin using NMR Residual Dipolar Couplings.γ-AApeptides bind to RNA by mimicking RNA-binding proteins.Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex.Coarse grained models reveal essential contributions of topological constraints to the conformational free energy of RNA bulges.Strategies to Block HIV Transcription: Focus on Small Molecule Tat Inhibitors.Artificial nucleobase-amino acid conjugates: a new class of TAR RNA binding agents.Native Top-Down Mass Spectrometry of TAR RNA in Complexes with a Wild-Type tat Peptide for Binding Site Mapping.Discovery of selective bioactive small molecules by targeting an RNA dynamic ensemble.Molecular dynamics and MM/GBSA-integrated protocol probing the correlation between biological activities and binding free energies of HIV-1 TAR RNA inhibitors.Molecular dynamics simulations identify time scale of conformational changes responsible for conformational selection in molecular recognition of HIV-1 transactivation responsive RNA.Deciphering structure-activity relationships in a series of Tat/TAR inhibitors.Hot-spot identification on a broad class of proteins and RNA suggest unifying principles of molecular recognition.Thermodynamic studies of a series of homologous HIV-1 TAR RNA ligands reveal that loose binders are stronger Tat competitors than tight ones.A new residue-nucleotide propensity potential with structural information considered for discriminating protein-RNA docking decoys.Using Genome Sequence to Enable the Design of Medicines and Chemical Probes.A modular synthesis of teraryl-based α-helix mimetics, part 1: Synthesis of core fragments with two electronically differentiated leaving groups.Structure of HIV TAR in complex with a Lab-Evolved RRM provides insight into duplex RNA recognition and synthesis of a constrained peptide that impairs transcription
P2860
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P2860
Essential structural requirements for specific recognition of HIV TAR RNA by peptide mimetics of Tat protein
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Essential structural requireme ...... eptide mimetics of Tat protein
@ast
Essential structural requireme ...... eptide mimetics of Tat protein
@en
Essential structural requireme ...... eptide mimetics of Tat protein
@nl
type
label
Essential structural requireme ...... eptide mimetics of Tat protein
@ast
Essential structural requireme ...... eptide mimetics of Tat protein
@en
Essential structural requireme ...... eptide mimetics of Tat protein
@nl
prefLabel
Essential structural requireme ...... eptide mimetics of Tat protein
@ast
Essential structural requireme ...... eptide mimetics of Tat protein
@en
Essential structural requireme ...... eptide mimetics of Tat protein
@nl
P2860
P3181
P356
P1476
Essential structural requireme ...... eptide mimetics of Tat protein
@en
P2093
Amy Davidson
John A Robinson
P2860
P304
P3181
P356
10.1093/NAR/GKQ713
P407
P577
2011-01-01T00:00:00Z