Exploration of the Active Site of Neuronal Nitric Oxide Synthase by the Design and Synthesis of Pyrrolidinomethyl 2-Aminopyridine Derivatives
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Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthaseStructure-Guided Design of Selective Inhibitors of Neuronal Nitric Oxide SynthaseIntramolecular hydrogen bonding: A potential strategy for more bioavailable inhibitors of neuronal nitric oxide synthaseChiral linkers to improve selectivity of double-headed neuronal nitric oxide synthase inhibitorsSelective Monocationic Inhibitors of Neuronal Nitric Oxide Synthase. Binding Mode Insights from Molecular Dynamics SimulationsPotent and Selective Double-Headed Thiophene-2-carboximidamide Inhibitors of Neuronal Nitric Oxide Synthase for the Treatment of MelanomaSimplified 2-Aminoquinoline-Based Scaffold for Potent and Selective Neuronal Nitric Oxide Synthase InhibitionAccessible Chiral Linker to Enhance Potency and Selectivity of Neuronal Nitric Oxide Synthase InhibitorsNitric Oxide Synthase Inhibitors That Interact with Both Heme Propionate and Tetrahydrobiopterin Show High Isoform SelectivityThe Mobility of a Conserved Tyrosine Residue Controls Isoform-Dependent Enzyme–Inhibitor Interactions in Nitric Oxide SynthasesnNOS inhibition during profound asphyxia reduces seizure burden and improves survival of striatal phenotypic neurons in preterm fetal sheep.Niflumic acid blocks native and recombinant T-type channelsDevelopment of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain.Nickel-Catalyzed [2+2+2] Cycloaddition of Diynes and Cyanamides.Novel 2,4-disubstituted pyrimidines as potent, selective, and cell-permeable inhibitors of neuronal nitric oxide synthaseHigh yielding allylation of a chiral secondary alcohol containing base sensitive functional groups2-Aminopyridines with a Truncated Side Chain To Improve Human Neuronal Nitric Oxide Synthase Inhibitory Potency and SelectivityAcid-Facilitated Debenzylation of N-Boc, N-Benzyl Double Protected 2-Aminopyridinomethylpyrrolidine DerivativesTarget- and mechanism-based therapeutics for neurodegenerative diseases: strength in numbersTargeting nitric oxide signaling with nNOS inhibitors as a novel strategy for the therapy and prevention of human melanoma.Partial neuroprotection by nNOS inhibition during profound asphyxia in preterm fetal sheep.Recent advances toward improving the bioavailability of neuronal nitric oxide synthase inhibitors.Fragment informatics and computational fragment-based drug design: an overview and update.Fluorination Effects on NOS Inhibitory Activity of Pyrazoles Related to Curcumin.Structural basis for isoform-selective inhibition in nitric oxide synthase.[5C + 1N] Annulation of 2,4-pentadienenitriles with hydroxylamine: a synthetic route to multi-substituted 2-aminopyridines.Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors.Access to Chiral Hydropyrimidines through Palladium-Catalyzed Asymmetric Allylic C-H Amination.Synthesis of a Potent Aminopyridine-Based nNOS-Inhibitor by Two Recent No-Carrier-Added (18)F-Labelling Methods.Insights into the structural determinants for selective inhibition of nitric oxide synthase isoforms
P2860
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P2860
Exploration of the Active Site of Neuronal Nitric Oxide Synthase by the Design and Synthesis of Pyrrolidinomethyl 2-Aminopyridine Derivatives
description
2010 nî lūn-bûn
@nan
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Exploration of the Active Site ...... yl 2-Aminopyridine Derivatives
@ast
Exploration of the Active Site ...... yl 2-Aminopyridine Derivatives
@en
Exploration of the Active Site ...... yl 2-Aminopyridine Derivatives
@nl
type
label
Exploration of the Active Site ...... yl 2-Aminopyridine Derivatives
@ast
Exploration of the Active Site ...... yl 2-Aminopyridine Derivatives
@en
Exploration of the Active Site ...... yl 2-Aminopyridine Derivatives
@nl
prefLabel
Exploration of the Active Site ...... yl 2-Aminopyridine Derivatives
@ast
Exploration of the Active Site ...... yl 2-Aminopyridine Derivatives
@en
Exploration of the Active Site ...... yl 2-Aminopyridine Derivatives
@nl
P2093
P2860
P356
P1476
Exploration of the active site ...... yl 2-aminopyridine derivatives
@en
P2093
Huiying Li
Linda J Roman
Richard B Silverman
Silvia L Delker
Thomas L Poulos
P2860
P304
P356
10.1021/JM100947X
P407
P577
2010-11-01T00:00:00Z