Autophosphorylation Activates Dictyostelium Myosin II Heavy Chain Kinase A by Providing a Ligand for an Allosteric Binding Site in the -Kinase Domain
about
Eukaryotic elongation factor 2 kinase as a drug target in cancer, and in cardiovascular and neurodegenerative diseasesThe molecular mechanism of eukaryotic elongation factor 2 kinase activationCalcium/calmodulin stimulates the autophosphorylation of elongation factor 2 kinase on Thr-348 and Ser-500 to regulate its activity and calcium dependenceRosetta FlexPepDock ab-initio: simultaneous folding, docking and refinement of peptides onto their receptors.SIMS: a hybrid method for rapid conformational analysis.Rosetta FlexPepDock web server--high resolution modeling of peptide-protein interactionsInsights into the regulation of eukaryotic elongation factor 2 kinase and the interplay between its domains.Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinaseCharacterization of the Catalytic and Nucleotide Binding Properties of the α-Kinase Domain of Dictyostelium Myosin-II Heavy Chain Kinase AStructure of the Dictyostelium Myosin-II Heavy Chain Kinase A (MHCK-A) α-kinase domain apoenzyme reveals a novel autoinhibited conformation.Mass Spectrometric Analysis of TRPM6 and TRPM7 Phosphorylation Reveals Regulatory Mechanisms of the Channel-Kinases.A conserved loop in the catalytic domain of eukaryotic elongation factor 2 kinase plays a key role in its substrate specificity.Regulated stability of eukaryotic elongation factor 2 kinase requires intrinsic but not ongoing activity.Significant reduction in errors associated with nonbonded contacts in protein crystal structures: automated all-atom refinement with PrimeX.
P2860
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P2860
Autophosphorylation Activates Dictyostelium Myosin II Heavy Chain Kinase A by Providing a Ligand for an Allosteric Binding Site in the -Kinase Domain
description
2011 nî lūn-bûn
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2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2011 թվականի հունվարին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年论文
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name
Autophosphorylation Activates ...... ng Site in the -Kinase Domain
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Autophosphorylation Activates ...... ng Site in the -Kinase Domain
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Autophosphorylation Activates ...... ng Site in the -Kinase Domain
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Autophosphorylation Activates ...... ng Site in the -Kinase Domain
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Autophosphorylation Activates ...... ng Site in the -Kinase Domain
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Autophosphorylation Activates ...... ng Site in the -Kinase Domain
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Autophosphorylation Activates ...... ng Site in the -Kinase Domain
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Autophosphorylation Activates ...... ng Site in the -Kinase Domain
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Autophosphorylation Activates ...... ng Site in the -Kinase Domain
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P2860
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Autophosphorylation Activates ...... ng Site in the -Kinase Domain
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P2093
Barak Raveh
Graham P Côté
Mojdeh Samimi Gharaei
Scott W Crawley
Yidai Yang
Zongchao Jia
P2860
P304
P3181
P356
10.1074/JBC.M110.177014
P407
P577
2011-01-28T00:00:00Z