Identification of a potent Janus kinase 3 inhibitor with high selectivity within the Janus kinase family
about
What is the purpose of launching the World Journal of Transplantation?Novel hinge-binding motifs for Janus kinase 3 inhibitors: a comprehensive structure-activity relationship study on tofacitinib bioisosteres.Mutations in RIPK4 cause the autosomal-recessive form of popliteal pterygium syndrome.Kinase inhibitors in the treatment of immune-mediated diseaseJAK Kinases in Health and Disease: An UpdateDistinct Acute Lymphoblastic Leukemia (ALL)-associated Janus Kinase 3 (JAK3) Mutants Exhibit Different Cytokine-Receptor Requirements and JAK Inhibitor Specificities.Establishing the role of tyrosine kinase 2 in cancer.Selective JAK1 inhibitor and selective Tyk2 inhibitor patents.New insights into the structure and function of the pseudokinase domain in JAK2.Selective JAK inhibitors.Oxindole-based SYK and JAK3 dual inhibitors for rheumatoid arthritis: designing, synthesis and biological evaluation.Development of Selective Covalent Janus Kinase 3 Inhibitors.The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells.Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket.Highly selective Janus kinase 3 inhibitors based on a pyrrolo[2,3-d]pyrimidine scaffold: evaluation of WO2013085802.Features of reactive cysteines discovered through computation: from kinase inhibition to enrichment around protein degrons.Molecular dynamics and integrated pharmacophore-based identification of dual [Formula: see text] inhibitors.Dual inhibitors of Janus kinase 2 and 3 (JAK2/3): designing by pharmacophore- and docking-based virtual screening approach.Discovery of a highly selective JAK3 inhibitor for the treatment of rheumatoid arthritis.Ligand-based and e-pharmacophore modeling, 3D-QSAR and hierarchical virtual screening to identify dual inhibitors of spleen tyrosine kinase (Syk) and janus kinase 3 (JAK3).Pharmacophore and docking-based virtual screening approach for the design of new dual inhibitors of Janus kinase 1 and Janus kinase 2.Discriminating phenotypic signatures identified for tocilizumab, adalimumab, and tofacitinib monotherapy and their combinations with methotrexate.
P2860
Q30486465-832F0E44-5E16-4B9B-8415-0059EA6ABC2DQ35228409-6413136E-D4A9-4F63-9DD5-AE8D7ECE9C12Q35671532-F904E737-49D6-4A20-9E41-F44626BBBC68Q35814037-9790868A-153B-4B20-A510-13F790CE4A4FQ36285745-A1BA3F44-EF68-4B95-A07E-B0098D810A4FQ36323519-215D0715-AB55-4E65-B6F7-7D218FE37260Q36643671-EE4ACC3C-C52E-45E8-8720-BAD45C20D65DQ38042734-1DDA5A4E-D99D-4EDA-A960-9B89F4587C32Q38122233-A9C06B32-C3BD-484F-BDE1-06367E182213Q38261371-CD31D1A1-77C7-493C-B978-6C9AC275C0E8Q38655324-60AD1D82-2285-470A-B59E-61BE49BAB568Q38763094-A23EA525-0FC9-49D7-ADD4-950567F44ABCQ39388632-12F367A2-DE5A-4871-B97A-6077F115506FQ41835379-D03F8695-D108-4C69-A3D5-EC2D3A718AD5Q46460981-3F682614-A2F7-494E-A5D7-860060F3269FQ47093526-79866216-AB73-4A94-9612-6A72C8C9ACA1Q47401024-75B8E2FA-BFEC-48F0-8355-D0E07F886538Q51759248-94C5CBD2-58B2-4752-AD12-C8C60CA7810EQ52626728-F7BA122E-9AED-4828-BCD9-A95E2F510030Q54172917-347F15DB-CC8E-4F20-96FC-76DE4C7E6DD7Q54327831-C1148A2F-5C2B-481D-BFF9-788E46D1F7F9Q55310713-745FD148-2F46-451C-9755-7BFE1F6879A9
P2860
Identification of a potent Janus kinase 3 inhibitor with high selectivity within the Janus kinase family
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Identification of a potent Jan ...... within the Janus kinase family
@ast
Identification of a potent Jan ...... within the Janus kinase family
@en
Identification of a potent Jan ...... within the Janus kinase family
@nl
type
label
Identification of a potent Jan ...... within the Janus kinase family
@ast
Identification of a potent Jan ...... within the Janus kinase family
@en
Identification of a potent Jan ...... within the Janus kinase family
@nl
prefLabel
Identification of a potent Jan ...... within the Janus kinase family
@ast
Identification of a potent Jan ...... within the Janus kinase family
@en
Identification of a potent Jan ...... within the Janus kinase family
@nl
P2093
P356
P1476
Identification of a potent Jan ...... within the Janus kinase family
@en
P2093
Erwin Hermes
Francois Nuninger
Gebhard Thoma
Gisele A Tavares
Rocco Falchetto
P356
10.1021/JM101157Q
P407
P577
2011-01-13T00:00:00Z