X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel
about
How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusionThe Intracellular Loop of the Glycine Receptor: It's not all about the SizeIonotropic GABA receptor antagonism-induced adverse outcome pathways for potential neurotoxicity biomarkersAnesthetics target interfacial transmembrane sites in nicotinic acetylcholine receptorsThe concept of allosteric interaction and its consequences for the chemistry of the brainThe impact of human hyperekplexia mutations on glycine receptor structure and functionThe nicotinic acetylcholine receptor: the founding father of the pentameric ligand-gated ion channel superfamilyPathways and Barriers for Ion Translocation through the 5-HT3A Receptor ChannelCommon Internal Allosteric Network Links Anesthetic Binding Sites in a Pentameric Ligand-Gated Ion ChannelCrystal structure of a human GABAA receptorStructure of the Pentameric Ligand-Gated Ion Channel GLIC Bound with Anesthetic KetamineStructural and Functional Characterization of an Anesthetic Binding Site in the Second Cysteine-Rich Domain of Protein Kinase Cδ∗Multisite Binding of a General Anesthetic to the Prokaryotic Pentameric Erwinia chrysanthemi Ligand-gated Ion Channel (ELIC)NMR structure and dynamics of a designed water-soluble transmembrane domain of nicotinic acetylcholine receptorStructural basis for ion permeation mechanism in pentameric ligand-gated ion channelsStructural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channelSignal Transduction Pathways in the Pentameric Ligand-Gated Ion ChannelsMutations that stabilize the open state of the Erwinia chrisanthemi ligand-gated ion channel fail to change the conformation of the pore domain in crystalsA locally closed conformation of a bacterial pentameric proton-gated ion channelOpen-channel structures of the human glycine receptor α1 full-length transmembrane domain.Insights into Distinct Modulation of 7 and 7 2 Nicotinic Acetylcholine Receptors by the Volatile Anesthetic IsofluraneCrystal structures of a pentameric ligand-gated ion channel provide a mechanism for activationStructural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonistEthanol Modulation is Quantitatively Determined by the Transmembrane Domain of Human α1 Glycine ReceptorsA predicted binding site for cholesterol on the GABAA receptorMapping general anesthetic binding site(s) in human α1β3 γ-aminobutyric acid type A receptors with [³H]TDBzl-etomidate, a photoreactive etomidate analogueMolecular mechanism for the dual alcohol modulation of Cys-loop receptorsMutations at beta N265 in γ-aminobutyric acid type A receptors alter both binding affinity and efficacy of potent anestheticsA Structural Model of the Human α7 Nicotinic Receptor in an Open ConformationThe Primitive Thylakoid-Less Cyanobacterium Gloeobacter Is a Common Rock-Dwelling OrganismClick Chemistry Reagent for Identification of Sites of Covalent Ligand Incorporation in Integral Membrane Proteins.Propofol binding to the resting state of the gloeobacter violaceus ligand-gated ion channel (GLIC) induces structural changes in the inter- and intrasubunit transmembrane domain (TMD) cavitiesMutations M287L and Q266I in the glycine receptor α1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but not the minimal alveolar concentration in knockin miceProbing the C-H⋅⋅⋅π weak hydrogen bond in anesthetic binding: the sevoflurane-benzene cluster.Allosteric modulation of glycine receptors.The Concise Guide to PHARMACOLOGY 2013/14: ligand-gated ion channels.Critical role of water in the binding of volatile anesthetics to proteins.A computationally designed water-soluble variant of a G-protein-coupled receptor: the human mu opioid receptor.Identification of a pre-active conformation of a pentameric channel receptorCurcumol allosterically modulates GABA(A) receptors in a manner distinct from benzodiazepines.
P2860
Q24273350-F8553948-5B07-447C-BF2B-281B943BFB9FQ26743781-80281E47-4561-41D1-8EF4-47B69956D448Q26778336-3F42F109-3CBE-43B1-A6CC-231ADCFE0AEEQ26824325-742173C5-9A61-45B6-B3D8-2F32D32D73FDQ26827321-A0110C38-A223-4CA2-97DB-2B00B4F3D278Q26830661-831DF240-2EF3-4D19-9FF8-606D798344D6Q26830810-655C260C-C963-4FEA-98A8-1AEE20F7A657Q27313796-3DC8A2A8-135D-4DDD-8065-563CD58A556BQ27335033-02F4DAD3-D9CC-4A38-9803-319D34909446Q27644591-2A6CF4C5-BD6B-468B-AA4D-E5C649B9D6BDQ27672696-2D60E6EB-0F7A-40FD-A2A7-9194950520FFQ27675695-E01B5767-B82D-434E-9DF1-81D3A1A0E06CQ27676065-13913818-8F0E-4578-A58E-019CC00AC8CCQ27676088-F225C88F-6A03-4135-8750-C3995A54745FQ27676348-85261C1F-AAE3-4AE6-A962-AE53FC285BEDQ27677407-7C8CA934-3BDF-4DD1-859F-0AF69673566EQ27678110-857AAB71-F1C4-4BFB-BF85-5879429AEFC8Q27678323-0F84ADB2-3ADB-459F-9772-D5BE51CFFF25Q27679065-99430379-C816-450D-A69E-02CFB0B0D8A3Q27679842-16CBA4B6-1397-4A08-B9EF-E2979680841AQ27680533-E6DAFCBC-4873-4FFD-BE19-E4BA0ED773C9Q27681074-86B0826C-29C2-4FEE-9711-784035FAA2D7Q27703155-04299E2C-9FC5-4552-8EC0-E921D314F4A3Q28115477-12E90577-8F31-41C6-95B6-FEA08F3A1542Q28239688-385AFFBB-6E49-4D80-A1B4-C59122FCF77EQ28257428-D2135B37-8A18-486F-86AD-0DBD85376F76Q28484223-098F8AA9-91EC-4B62-A067-C16AEC3C0F3CQ28544412-F0118240-12A6-4538-9203-A525F8CCD9D1Q28546747-92B2D58E-D6AE-4378-941D-7E284467FA23Q28681244-465D7478-352B-463C-8DE8-DCB9D842EBC5Q30398567-152F7203-A612-4306-8225-03C6950CB7D2Q30430090-DDE68BFD-FBFB-4814-936C-696A4A15AA12Q30448542-9F6200EA-60F1-461C-B759-92B3756CAD62Q30457403-57C4B8C0-0CB6-4DC8-9330-97C34F0E9AADQ30464018-78FAF992-F095-4361-A7DD-F277115EAB3FQ30486732-C1F3697F-4B6E-45F3-BBF1-6E9E500F7259Q30667813-927AF9EA-145C-4E82-89FE-D3C6902745D4Q31120649-996E9416-8ECA-492C-A8EB-74E71BBBA314Q33585840-0ACACADA-4AE5-4F31-A04A-605DAF4989A5Q33594728-5E6B9E6B-B0E5-4DFC-A213-BE7651AFE565
P2860
X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel
@ast
X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel
@en
X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel
@nl
type
label
X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel
@ast
X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel
@en
X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel
@nl
prefLabel
X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel
@ast
X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel
@en
X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel
@nl
P2093
P50
P3181
P356
P1433
P1476
X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel
@en
P2093
Alphonso Tran
Catherine Van Renterghem
James M Sonner
Virginie Dufresne
P2888
P304
P3181
P356
10.1038/NATURE09647
P407
P577
2011-01-20T00:00:00Z
P5875
P6179
1026555872