Molecular mechanism for the dual alcohol modulation of Cys-loop receptors - Wikidata - awgldk - TriplyDB

Molecular mechanism for the dual alcohol modulation of Cys-loop receptors

Molecular mechanism for the dual alcohol modulation of Cys-loop receptors

http://www.wikidata.org/entity/Q28484223

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Proteomic approaches and identification of novel therapeutic targets for alcoholism Exploring volatile general anesthetic binding to a closed membrane-bound bacterial voltage-gated sodium channel via computation Beyond Membrane Protein Structure: Drug Discovery, Dynamics and Difficulties.Propofol binding to the resting state of the gloeobacter violaceus ligand-gated ion channel (GLIC) induces structural changes in the inter- and intrasubunit transmembrane domain (TMD) cavities A membrane-embedded pathway delivers general anesthetics to two interacting binding sites in the Gloeobacter violaceus ion channel.GABA(A) receptor transmembrane amino acids are critical for alcohol action: disulfide cross-linking and alkyl methanethiosulfonate labeling reveal relative location of binding sites Atomistic models of general anesthetics for use in in silico biological studies Evidence for α-helices in the large intracellular domain mediating modulation of the α1-glycine receptor by ethanol and Gβγ.Molecular modeling of a tandem two pore domain potassium channel reveals a putative binding site for general anesthetics.Inter- and Intra-Subunit Butanol/Isoflurane Sites of Action in the Human Glycine Receptor.Identification of an Inhibitory Alcohol Binding Site in GABAA ρ1 Receptors Stabilization of the GluCl ligand-gated ion channel in the presence and absence of ivermectin Inhibition versus potentiation of ligand-gated ion channels can be altered by a single mutation that moves ligands between intra- and intersubunit sites Functional validation of virtual screening for novel agents with general anesthetic action at ligand-gated ion channels Assessment of homology templates and an anesthetic binding site within the γ-aminobutyric acid receptor.Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics.Pentameric Ligand-gated Ion Channels : Insights from Computation.Nicotine at clinically relevant concentrations affects atrial inward rectifier potassium current sensitive to acetylcholine.Effect of ethanol at clinically relevant concentrations on atrial inward rectifier potassium current sensitive to acetylcholine.The cellular membrane as a mediator for small molecule interaction with membrane proteins.Mapping Two Neurosteroid Modulatory Sites in the Prototypic Pentameric Ligand Gated Ion Channel GLIC.Molecular basis for potentiation of Cx36 gap junction channel conductance by n-alcohols and general anesthetics.Full mutational mapping of titratable residues helps to identify proton-sensors involved in the control of channel gating in the Gloeobacter violaceus pentameric ligand-gated ion channel.Inward rectifying potassium currents resolved into components: modeling of complex drug actions.Simulation of Ligand Binding to Membrane Proteins.The Glycine Receptor-A Functionally Important Primary Brain Target of Ethanol.Alcohol reduces muscle fatigue through atomistic interactions with nicotinic receptors

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Molecular mechanism for the dual alcohol modulation of Cys-loop receptors

http://www.wikidata.org/entity/Q28484223

description

2012 nî lūn-bûn

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2012 թուականին հրատարակուած գիտական յօդուած

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2012 թվականին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

Molecular mechanism for the dual alcohol modulation of Cys-loop receptors

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Molecular mechanism for the dual alcohol modulation of Cys-loop receptors

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Molecular mechanism for the dual alcohol modulation of Cys-loop receptors

@nl

type

label

Molecular mechanism for the dual alcohol modulation of Cys-loop receptors

@ast

Molecular mechanism for the dual alcohol modulation of Cys-loop receptors

@en

Molecular mechanism for the dual alcohol modulation of Cys-loop receptors

@nl

prefLabel

Molecular mechanism for the dual alcohol modulation of Cys-loop receptors

@ast

Molecular mechanism for the dual alcohol modulation of Cys-loop receptors

@en

Molecular mechanism for the dual alcohol modulation of Cys-loop receptors

@nl

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JOURNAL.PCBI.1002710

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PLOS Computational Biology

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Molecular mechanism for the dual alcohol modulation of Cys-loop receptors

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P2093

Edward J Bertaccini

http://www.w3.org/2001/XMLSchema#string

James R Trudell

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R Adron Harris

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Torben Broemstrup

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P2860

Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors

X-ray structure of a prokaryotic pentameric ligand-gated ion channel

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

Principles of activation and permeation in an anion-selective Cys-loop receptor

Mutations that stabilize the open state of the Erwinia chrisanthemi ligand-gated ion channel fail to change the conformation of the pore domain in crystals

A locally closed conformation of a bacterial pentameric proton-gated ion channel

VMD: visual molecular dynamics

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e1002710

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10.1371/JOURNAL.PCBI.1002710

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10

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Rebecca J Howard

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