Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery
about
Structural and functional characterization of a cell cycle associated HDAC1/2 complex reveals the structural basis for complex assembly and nucleosome targetingActivation of p53 transcriptional activity by SMRT: a histone deacetylase 3-independent function of a transcriptional corepressorStructure of HDAC3 bound to co-repressor and inositol tetraphosphateClass I HDACs Share a Common Mechanism of Regulation by Inositol PhosphatesThe ansamycin antibiotic, rifamycin SV, inhibits BCL6 transcriptional repression and forms a complex with the BCL6-BTB/POZ domainEbi/AP-1 suppresses pro-apoptotic genes expression and permits long-term survival of Drosophila sensory neuronsMedulloblastoma exome sequencing uncovers subtype-specific somatic mutationsStructure of the MeCP2-TBLR1 complex reveals a molecular basis for Rett syndrome and related disorders.De novo non-synonymous TBL1XR1 mutation alters Wnt signaling activity.SUMOylation of GPS2 protein regulates its transcription-suppressing function.Nuclear receptor corepressor complexes in cancer: mechanism, function and regulationThe optimal corepressor function of nuclear receptor corepressor (NCoR) for peroxisome proliferator-activated receptor γ requires G protein pathway suppressor 2.Pre-clinical efficacy of combined therapy with novel β-catenin antagonist BC2059 and histone deacetylase inhibitor against AML cellsMutagenesis Study Reveals the Rim of Catalytic Entry Site of HDAC4 and -5 as the Major Binding Surface of SMRT CorepressorExchange Factor TBL1 and Arginine Methyltransferase PRMT6 Cooperate in Protecting G Protein Pathway Suppressor 2 (GPS2) from Proteasomal Degradation.An ancient Pygo-dependent Wnt enhanceosome integrated by Chip/LDB-SSDP.The coding genome of splenic marginal zone lymphoma: activation of NOTCH2 and other pathways regulating marginal zone development.Transcriptional Regulation by Nuclear Corepressors and PGC-1α: Implications for Mitochondrial Quality Control and Insulin Sensitivity.The in vivo role of nuclear receptor corepressors in thyroid hormone action.SMRT-GPS2 corepressor pathway dysregulation coincides with obesity-linked adipocyte inflammation.Aldose Reductase Acts as a Selective Derepressor of PPARγ and the Retinoic Acid Receptor.General molecular biology and architecture of nuclear receptors.Emerging roles of the corepressors NCoR1 and SMRT in homeostasis.A closed-loop synthetic gene circuit for the treatment of diet-induced obesity in mice.Photoreactive "nanorulers" detect a novel conformation of full length HDAC3-SMRT complex in solutionMedulloblastomics: the end of the beginning.Mutations in TBL1X Are Associated With Central Hypothyroidism.Nuclear hormone receptor co-repressors: structure and function.The role of chromatin remodeling in medulloblastoma.An evolving understanding of nuclear receptor coregulator proteins.Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes.USP44 Is an Integral Component of N-CoR that Contributes to Gene Repression by Deubiquitinating Histone H2B.TGF-β induces miR-30d down-regulation and podocyte injury through Smad2/3 and HDAC3-associated transcriptional repression.Genetic and epigenomic mechanisms of mammalian circadian transcriptionThe actions of thyroid hormone signaling in the nucleus.The structure of the core NuRD repression complex provides insights into its interaction with chromatin.Genetic characterization of ebi reveals its critical role in Drosophila wing growthInsights into the Recruitment of Class IIa Histone Deacetylases (HDACs) to the SMRT/NCoR Transcriptional Repression Complex.A specific mutation in TBL1XR1 causes Pierpont syndrome.Systemic insulin sensitivity is regulated by GPS2 inhibition of AKT ubiquitination and activation in adipose tissue.
P2860
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P2860
Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery
description
2011 nî lūn-bûn
@nan
2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Structural basis for the assem ...... riptional repression machinery
@ast
Structural basis for the assem ...... riptional repression machinery
@en
Structural basis for the assem ...... riptional repression machinery
@nl
type
label
Structural basis for the assem ...... riptional repression machinery
@ast
Structural basis for the assem ...... riptional repression machinery
@en
Structural basis for the assem ...... riptional repression machinery
@nl
prefLabel
Structural basis for the assem ...... riptional repression machinery
@ast
Structural basis for the assem ...... riptional repression machinery
@en
Structural basis for the assem ...... riptional repression machinery
@nl
P2093
P2860
P50
P3181
P356
P1476
Structural basis for the assem ...... riptional repression machinery
@en
P2093
Bettina C Kallenberger
David Neuhaus
Jacquie A Greenwood
Jasmeen Oberoi
Ji-Chun Yang
John T Gooch
Peter J Watson
Thorsten Kampmann
Zsolt Czimmerer
P2860
P2888
P304
P3181
P356
10.1038/NSMB.1983
P577
2011-01-16T00:00:00Z
P5875
P6179
1027186475