Discovery and characterization of a cell-permeable, small-molecule c-Abl kinase activator that binds to the myristoyl binding site
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Quantitative analysis of HSP90-client interactions reveals principles of substrate recognitionc-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's diseaseTen things you should know about protein kinases: IUPHAR Review 14Role of N-Terminal Myristylation in the Structure and Regulation of cAMP-Dependent Protein KinaseFluorescence Polarization Screening Assays for Small Molecule Allosteric Modulators of ABL Kinase Functionc-Abl Tyrosine Kinase Adopts Multiple Active Conformational States in SolutionDefying c-Abl signaling circuits through small allosteric compounds.NMR reveals the allosteric opening and closing of Abelson tyrosine kinase by ATP-site and myristoyl pocket inhibitors.Targeting protein lipidation in diseaseConditionally and transiently disordered proteins: awakening cryptic disorder to regulate protein function.A phosphotyrosine switch determines the antitumor activity of ERβ.Dysregulation of catalase activity in newborn myocytes during hypoxia is mediated by c-Abl tyrosine kinase.Structure-guided optimization of small molecule c-Abl activatorsC-Abl inhibitor imatinib enhances insulin production by β cells: c-Abl negatively regulates insulin production via interfering with the expression of NKx2.2 and GLUT-2.Direct interactions with the integrin β1 cytoplasmic tail activate the Abl2/Arg kinase.The ins and outs of selective kinase inhibitor development.Structure and dynamic regulation of Abl kinases.c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells.Normal ABL1 is a tumor suppressor and therapeutic target in human and mouse leukemias expressing oncogenic ABL1 kinases.Novel approaches for targeting kinases: allosteric inhibition, allosteric activation and pseudokinases.α3β1 Integrin Suppresses Prostate Cancer Metastasis via Regulation of the Hippo Pathway.The Src kinases Hck, Fgr and Lyn activate Arg to facilitate IgG-mediated phagocytosis and Leishmania infection.Mutant p53 dictates the oncogenic activity of c-Abl in triple-negative breast cancers.Structure-based design, synthesis and crystallization of 2-arylquinazolines as lipid pocket ligands of p38α MAPK.Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells.Allosteric BCR-ABL inhibitors in Philadelphia chromosome-positive acute lymphoblastic leukemia: novel opportunities for drug combinations to overcome resistance.Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.c-Abl-mediated Drp1 phosphorylation promotes oxidative stress-induced mitochondrial fragmentation and neuronal cell death.Active site-adjacent phosphorylation at Tyr-397 by c-Abl kinase inactivates caspase-9.EphB4 Regulates Self-Renewal, Proliferation and Neuronal Differentiation of Human Embryonic Neural Stem Cells in Vitro.Allosterische Kinaseinhibitoren
P2860
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P2860
Discovery and characterization of a cell-permeable, small-molecule c-Abl kinase activator that binds to the myristoyl binding site
description
2011 nî lūn-bûn
@nan
2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Discovery and characterization ...... to the myristoyl binding site
@ast
Discovery and characterization ...... to the myristoyl binding site
@en
Discovery and characterization ...... to the myristoyl binding site
@nl
type
label
Discovery and characterization ...... to the myristoyl binding site
@ast
Discovery and characterization ...... to the myristoyl binding site
@en
Discovery and characterization ...... to the myristoyl binding site
@nl
prefLabel
Discovery and characterization ...... to the myristoyl binding site
@ast
Discovery and characterization ...... to the myristoyl binding site
@en
Discovery and characterization ...... to the myristoyl binding site
@nl
P2093
P3181
P1476
Discovery and characterization ...... to the myristoyl binding site
@en
P2093
Allen Oliff
Brett Siegfried
Connie Erickson-Miller
Da-Yuan Wang
Francesca Zappacosta
George Burton
Glenn Hofmann
Graham Simpson
Hong Zhang
P304
P3181
P356
10.1016/J.CHEMBIOL.2010.12.013
P577
2011-02-25T00:00:00Z