Structure-guided optimization of small molecule c-Abl activators - Wikidata - awgldk - TriplyDB

Structure-guided optimization of small molecule c-Abl activators

Structure-guided optimization of small molecule c-Abl activators

http://www.wikidata.org/entity/Q35103542

about

Defying c-Abl signaling circuits through small allosteric compounds.Normal ABL1 is a tumor suppressor and therapeutic target in human and mouse leukemias expressing oncogenic ABL1 kinases.

P2860

Q30009269-9B75429C-8A99-4C77-964D-394297A8BD94 Q36851400-AA28C586-355F-4D1B-93AA-9B17F3AF7CD6

P2860

Structure-guided optimization of small molecule c-Abl activators

http://www.wikidata.org/entity/Q35103542

description

2014 nî lūn-bûn

@nan

2014 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2014年の論文

@ja

2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

Structure-guided optimization of small molecule c-Abl activators

@ast

Structure-guided optimization of small molecule c-Abl activators

@en

type

label

Structure-guided optimization of small molecule c-Abl activators

@ast

Structure-guided optimization of small molecule c-Abl activators

@en

prefLabel

Structure-guided optimization of small molecule c-Abl activators

@ast

Structure-guided optimization of small molecule c-Abl activators

@en

P1433

Q35103542-78547DD3-5A35-49FF-B0BF-C72FF4DD4960

P1476

Q35103542-216A87F6-7554-498D-826A-37D00A72A90D

P2093

Q35103542-098DA1EC-6E8A-404A-B324-C28B6C46A289

Q35103542-0B079F51-A9A4-4B9D-8E47-097A7E1415AD

Q35103542-0CEA3BF7-6857-41D7-A6F0-051EC9D78360

Q35103542-174C0A95-8987-48E8-BF41-B8E6A7888AD3

Q35103542-1F67F51C-0101-4EAA-889A-4E578974C683

Q35103542-1F9F8777-74C2-46E9-9B76-581E9157F8C1

Q35103542-280F170F-241D-41C4-B95A-65373731B3E8

Q35103542-2EBE87DA-C3C8-4003-9272-C50060E3B93F

Q35103542-7A478520-30D1-415A-A58D-6DE5D2389271

Q35103542-7B483956-E9FA-4200-969E-51D1169EC37D

P2860

Q35103542-16B0B8F5-BF31-4B4F-A39E-26E1B82BE767

Q35103542-17A637E8-AE77-4FEE-AEBF-6A864A6C78B0

Q35103542-19A1D7BA-CFFB-41B8-B34E-73BEDD12BA35

Q35103542-2792167E-F655-40AA-9EAD-8A017CDF14BC

Q35103542-2AA76998-8F63-408B-9C3E-BEFAE34ACB6A

Q35103542-2B9E72E2-477F-4A5F-A34D-A64CEE40F486

Q35103542-2E44B7B0-95F2-4A28-85C7-17E4926217B1

Q35103542-41934C43-E1DD-4ED2-A1C1-1A181D261469

Q35103542-4D8CE57F-A25D-4D77-BCFF-C58BE7630049

Q35103542-6D5DE53A-BAF1-4B37-AD94-495AC395F455

P2888

Q35103542-42AF5FCD-F144-4DAA-BDF1-4BF573AF06EB

P304

Q35103542-14DC9941-301F-4D98-852C-22418CCE06D0

P31

Q35103542-0743C89C-AD49-4ED6-AA1A-657180E4597D

P356

Q35103542-38F9CE6F-BAEF-4AB5-860C-B40B5AAE694E

P433

Q35103542-012438D8-C146-4433-B18B-505DA1ED7984

P478

Q35103542-EA2E1FC1-50FB-426A-9D2A-2840C0B15FE2

P50

Q35103542-7434F4FD-4CCF-4D33-855E-0AA93D2FD7D7

P577

Q35103542-F1AB1B8F-9615-4BA8-8F21-29683080B836

P5875

Q35103542-0D8F6A7A-4504-4597-A89A-2974343C0F33

P698

Q35103542-EE77E9D9-5EF3-4D5C-A1AD-B50C077EEF92

P932

Q35103542-EF380194-1300-4996-A244-A710C703A41A

P356

S10822-014-9731-5

P1433

Journal of Computer - Aided Molecular Design

P1476

Structure-guided optimization of small molecule c-Abl activators

@en

P2093

Donghui Qin

http://www.w3.org/2001/XMLSchema#string

George Burton

http://www.w3.org/2001/XMLSchema#string

Graham Simpson

http://www.w3.org/2001/XMLSchema#string

Helen Evans

http://www.w3.org/2001/XMLSchema#string

Hong Zhang

http://www.w3.org/2001/XMLSchema#string

Hu Li

http://www.w3.org/2001/XMLSchema#string

Jingsong Yang

http://www.w3.org/2001/XMLSchema#string

Josh Cottom

http://www.w3.org/2001/XMLSchema#string

Julien Chabanet

http://www.w3.org/2001/XMLSchema#string

Junya Qu

http://www.w3.org/2001/XMLSchema#string

P2860

Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571)

Structural basis for the autoinhibition of c-Abl tyrosine kinase

Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors

Binding or bending: distinction of allosteric Abl kinase agonists from antagonists by an NMR-based conformational assay

Discovery and characterization of a cell-permeable, small-molecule c-Abl kinase activator that binds to the myristoyl binding site

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene

Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase

Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase.

Conformational disturbance in Abl kinase upon mutation and deregulation.

P2888

s10822-014-9731-5

P304

75-87

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1007/S10822-014-9731-5

http://www.w3.org/2001/XMLSchema#string

P433

2

http://www.w3.org/2001/XMLSchema#string

P478

28

http://www.w3.org/2001/XMLSchema#string

P50

Jennifer A Borthwick

P577

2014-02-27T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

260395429

http://www.w3.org/2001/XMLSchema#string

P698

24573412

http://www.w3.org/2001/XMLSchema#string

P932

3949015

http://www.w3.org/2001/XMLSchema#string