Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors - Wikidata - awgldk - TriplyDB

Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors

Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors

http://www.wikidata.org/entity/Q27667580

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Functional insights from glutamate receptor ion channel structures NMDA receptor modulators: an updated patent review (2013-2014)Structural Determinants of Agonist Efficacy at the Glutamate Binding Site of N-Methyl-D-Aspartate Receptors Structural Insights into Competitive Antagonism in NMDA Receptors Three rare diseases in one Sib pair: RAI1, PCK1, GRIN2B mutations associated with Smith–Magenis Syndrome, cytosolic PEPCK deficiency and NMDA receptor glutamate insensitivity Crystal structure of a heterotetrameric NMDA receptor ion channel Activation of NMDA receptors and the mechanism of inhibition by ifenprodil.GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe Epileptic Encephalopathy Treatable with NMDA Receptor Channel Blockers Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulator.Expression of glutamatergic genes in healthy humans across 16 brain regions; altered expression in the hippocampus after chronic exposure to alcohol or cocaine Reduced curvature of ligand-binding domain free-energy surface underlies partial agonism at NMDA receptors.Context-dependent GluN2B-selective inhibitors of NMDA receptor function are neuroprotective with minimal side effects.Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunit-selective modulators New advances in NMDA receptor pharmacology.Emerging structural insights into the function of ionotropic glutamate receptors.Subunit-selective allosteric inhibition of glycine binding to NMDA receptors Molecular Mechanism of Disease-Associated Mutations in the Pre-M1 Helix of NMDA Receptors and Potential Rescue Pharmacology.A de novo loss-of-function GRIN2A mutation associated with childhood focal epilepsy and acquired epileptic aphasia.Structure-activity relationships and pharmacophore model of a noncompetitive pyrazoline containing class of GluN2C/GluN2D selective antagonists.Contribution of the M1 transmembrane helix and pre-M1 region to positive allosteric modulation and gating of N-methyl-D-aspartate receptors An NMDA receptor gating mechanism developed from MD simulations reveals molecular details underlying subunit-specific contributions.Mechanistic Insight into NMDA Receptor Dysregulation by Rare Variants in the GluN2A and GluN2B Agonist Binding Domains.Prediction of N-Methyl-D-Aspartate Receptor GluN1-Ligand Binding Affinity by a Novel SVM-Pose/SVM-Score Combinatorial Ensemble Docking Scheme Specific Roles of NMDA Receptor Subunits in Mental Disorders.Structure and function of glutamate receptor amino terminal domains.Copper-dependent regulation of NMDA receptors by cellular prion protein: implications for neurodegenerative disorders.Influence of GluN2 subunit identity on NMDA receptor function.Glutamate receptors function as scaffolds for the regulation of β-amyloid and cellular prion protein signaling complexes.Allosteric Interactions between NMDA Receptor Subunits Shape the Developmental Shift in Channel Properties.Semiclosed Conformations of the Ligand-Binding Domains of NMDA Receptors during Stationary Gating.Modal gating of GluN1/GluN2D NMDA receptors.GluN1 splice variant control of GluN1/GluN2D NMDA receptors.Single-molecule patch-clamp FRET microscopy studies of NMDA receptor ion channel dynamics in living cells: revealing the multiple conformational states associated with a channel at its electrical off state.Novel Functional Properties of Drosophila CNS Glutamate Receptors.NMDA Receptors in the Central Nervous System.Subtype-Specific Agonists for NMDA Receptor Glycine Binding Sites.Functional Evaluation of a De Novo GRIN2A Mutation Identified in a Patient with Profound Global Developmental Delay and Refractory Epilepsy.Altered Synaptic and Extrasynaptic NMDA Receptor Properties in Substantia Nigra Dopaminergic Neurons From Mice Lacking the GluN2D Subunit A structurally derived model of subunit-dependent NMDA receptor function

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Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors

http://www.wikidata.org/entity/Q27667580

description

2011 nî lūn-bûn

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2011年の論文

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name

Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors

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Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors

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Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors

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type

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Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors

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Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors

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Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors

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prefLabel

Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors

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Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors

@en

Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors

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Nature Communications

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Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors

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Hiro Furukawa

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Katie M Vance

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Noriko Simorowski

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Stephen F Traynelis

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Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors

Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core

Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core

Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors

Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

Coot: model-building tools for molecular graphics

Phasercrystallographic software

PHENIX: building new software for automated crystallographic structure determination

Mechanism of positive allosteric modulators acting on AMPA receptors

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10.1038/NCOMMS1295

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2

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2011-01-01T00:00:00Z

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1046205300

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21522138

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3302728

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