The crystal structure of yeast CCT reveals intrinsic asymmetry of eukaryotic cytosolic chaperonins
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Human TRiC complex purified from HeLa cells contains all eight CCT subunits and is active in vitroContribution of the Type II Chaperonin, TRiC/CCT, to OncogenesisThe dynamic conformational cycle of the group I chaperonin C-termini revealed via molecular dynamics simulationSymmetry-free cryo-EM structures of the chaperonin TRiC along its ATPase-driven conformational cycle.Mechanism of nucleotide sensing in group II chaperoninsThe Crystal Structures of the Eukaryotic Chaperonin CCT Reveal Its Functional PartitioningFlexible interwoven termini determine the thermal stability of thermosomesThe molecular architecture of the eukaryotic chaperonin TRiC/CCTCmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control.Dynamics, flexibility, and allostery in molecular chaperoninsAsymmetry in the function and dynamics of the cytosolic group II chaperonin CCT/TRiCPlasmodium actin is incompletely folded by heterologous protein-folding machinery and likely requires the native Plasmodium chaperonin complex to enter a mature functional state.Sequential allosteric mechanism of ATP hydrolysis by the CCT/TRiC chaperone is revealed through Arrhenius analysisEssential role of the chaperonin CCT in rod outer segment biogenesisStructure of the human TRiC/CCT Subunit 5 associated with hereditary sensory neuropathy.Structures of the Gβ-CCT and PhLP1-Gβ-CCT complexes reveal a mechanism for G-protein β-subunit folding and Gβγ dimer assembly.Subunit order of eukaryotic TRiC/CCT chaperonin by cross-linking, mass spectrometry, and combinatorial homology modeling.Weak intra-ring allosteric communications of the archaeal chaperonin thermosome revealed by normal mode analysisInteractions of subunit CCT3 in the yeast chaperonin CCT/TRiC with Q/N-rich proteins revealed by high-throughput microscopy analysis.Folding of large multidomain proteins by partial encapsulation in the chaperonin TRiC/CCT.A gradient of ATP affinities generates an asymmetric power stroke driving the chaperonin TRIC/CCT folding cycle.Human CCT4 and CCT5 chaperonin subunits expressed in Escherichia coli form biologically active homo-oligomers.TRiC's tricks inhibit huntingtin aggregation.Chaperonin TRiC/CCT Recognizes Fusion Oncoprotein AML1-ETO through Subunit-Specific Interactions.Visualizing chaperone-assisted protein folding.Splice isoforms of phosducin-like protein control the expression of heterotrimeric G proteinsKdm3a lysine demethylase is an Hsp90 client required for cytoskeletal rearrangements during spermatogenesis.Controlling the cortical actin motor.ATP-driven molecular chaperone machines.The Mechanism and Function of Group II Chaperonins.Designing disorder: Tales of the unexpected tails.Staggered ATP binding mechanism of eukaryotic chaperonin TRiC (CCT) revealed through high-resolution cryo-EM.Chaperone-client interactions: Non-specificity engenders multifunctionality.Chaperones: needed for both the good times and the bad times.DockStar: a novel ILP-based integrative method for structural modeling of multimolecular protein complexes.Group II archaeal chaperonin recognition of partially folded human γD-crystallin mutantsDysfunctional nitric oxide signalling increases risk of myocardial infarction.The chaperonin CCT interacts with and mediates the correct folding and activity of three subunits of translation initiation factor eIF3: b, i and h.Quantitative analysis of chaperone network throughput in budding yeast.Intraring allostery controls the function and assembly of a hetero-oligomeric class II chaperonin.
P2860
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P2860
The crystal structure of yeast CCT reveals intrinsic asymmetry of eukaryotic cytosolic chaperonins
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
The crystal structure of yeast ...... karyotic cytosolic chaperonins
@ast
The crystal structure of yeast ...... karyotic cytosolic chaperonins
@en
The crystal structure of yeast ...... karyotic cytosolic chaperonins
@nl
type
label
The crystal structure of yeast ...... karyotic cytosolic chaperonins
@ast
The crystal structure of yeast ...... karyotic cytosolic chaperonins
@en
The crystal structure of yeast ...... karyotic cytosolic chaperonins
@nl
prefLabel
The crystal structure of yeast ...... karyotic cytosolic chaperonins
@ast
The crystal structure of yeast ...... karyotic cytosolic chaperonins
@en
The crystal structure of yeast ...... karyotic cytosolic chaperonins
@nl
P2093
P2860
P3181
P356
P1433
P1476
The crystal structure of yeast ...... karyotic cytosolic chaperonins
@en
P2093
Carien Dekker
Elizabeth A McCormack
Fabienne Beuron
S Mark Roe
P2860
P304
P3181
P356
10.1038/EMBOJ.2011.208
P407
P577
2011-06-24T00:00:00Z