A combinatorial histidine scanning library approach to engineer highly pH-dependent protein switches
about
Structural basis of an engineered dual-specific antibody: conformational diversity leads to a hypervariable loop metal-binding siteTargeting FcRn for the modulation of antibody dynamicsEngineering an Anti-Transferrin Receptor ScFv for pH-Sensitive Binding Leads to Increased Intracellular AccumulationConsidering protonation as a posttranslational modification regulating protein structure and function.The effect of pH dependence of antibody-antigen interactions on subcellular trafficking dynamics.Engineered protein A ligands, derived from a histidine-scanning library, facilitate the affinity purification of IgG under mild acidic conditions.Design of pH sensitive binding proteins from the hyperthermophilic Sso7d scaffoldComputational design of a pH-sensitive IgG binding protein.Construction of pH-sensitive Her2-binding IgG1-Fc by directed evolution.Applications for an engineered Protein-G variant with a pH controllable affinity to antibody fragments.A generic approach to engineer antibody pH-switches using combinatorial histidine scanning libraries and yeast displaypH responsive granulocyte colony-stimulating factor variants with implications for treating Alzheimer's disease and other central nervous system disorders.Engineering pH responsive fibronectin domains for biomedical applications.Increasing serum half-life and extending cholesterol lowering in vivo by engineering antibody with pH-sensitive binding to PCSK9Isolation of a pH-Sensitive IgNAR Variable Domain from a Yeast-Displayed, Histidine-Doped Master Library.What Mutagenesis Can and Cannot Reveal About Allostery.Using Evolution to Guide Protein Engineering: The Devil IS in the Details.Engineering a pH responsive pore forming protein.Defining the metal specificity of a multifunctional biofilm adhesion protein.Sweeping antibody as a novel therapeutic antibody modality capable of eliminating soluble antigens from circulation.A strategy to identify linker-based modules for the allosteric regulation of antibody-antigen binding affinities of different scFvs.The intrinsic cysteine and histidine residues of the anti-Salmonella antibody Se155-4: a model for the introduction of new functions into antibody-binding sites.De novo isolation of antibodies with pH-dependent binding properties
P2860
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P2860
A combinatorial histidine scanning library approach to engineer highly pH-dependent protein switches
description
2011 nî lūn-bûn
@nan
2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
A combinatorial histidine scan ...... pH-dependent protein switches
@ast
A combinatorial histidine scan ...... pH-dependent protein switches
@en
A combinatorial histidine scan ...... pH-dependent protein switches
@nl
type
label
A combinatorial histidine scan ...... pH-dependent protein switches
@ast
A combinatorial histidine scan ...... pH-dependent protein switches
@en
A combinatorial histidine scan ...... pH-dependent protein switches
@nl
prefLabel
A combinatorial histidine scan ...... pH-dependent protein switches
@ast
A combinatorial histidine scan ...... pH-dependent protein switches
@en
A combinatorial histidine scan ...... pH-dependent protein switches
@nl
P2093
P2860
P356
P1433
P1476
A combinatorial histidine scan ...... pH-dependent protein switches
@en
P2093
Alexandra M Terry
James R Horn
Megan L Murtaugh
Sean W Fanning
Tressa M Sharma
P2860
P304
P356
10.1002/PRO.696
P577
2011-09-01T00:00:00Z