Determining the molecular mechanism of inactivation by chemical modification of triosephosphate isomerase from the human parasite Giardia lamblia: a study for antiparasitic drug design
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Structural and functional perturbation of Giardia lamblia triosephosphate isomerase by modification of a non-catalytic, non-conserved regionDifferent contribution of conserved amino acids to the global properties of triosephosphate isomerasesReversibility and two state behaviour in the thermal unfolding of oligomeric TIM barrel proteinsStructural effects of protein aging: terminal marking by deamidation in human triosephosphate isomerase.Structural and thermodynamic folding characterization of triosephosphate isomerases from Trichomonas vaginalis reveals the role of destabilizing mutations following gene duplication.The stability of G6PD is affected by mutations with different clinical phenotypes.Structural Basis for Redox Regulation of Cytoplasmic and Chloroplastic Triosephosphate Isomerases from Arabidopsis thaliana.Cytosolic Triosephosphate Isomerase from Arabidopsis thaliana Is Reversibly Modified by Glutathione on Cysteines 127 and 218.A guide to the effects of a large portion of the residues of triosephosphate isomerase on catalysis, stability, druggability, and human disease.Cloning, Expression and Characterization of Recombinant, NADH Oxidase from Giardia lamblia.Novel giardicidal compounds bearing proton pump inhibitor scaffold proceeding through triosephosphate isomerase inactivation.Giardial triosephosphate isomerase as possible target of the cytotoxic effect of omeprazole in Giardia lambliaCellular and biochemical characterization of two closely related triosephosphate isomerases from Trichomonas vaginalis.Mutations of Glucose-6-Phosphate Dehydrogenase Durham, Santa-Maria and A+ Variants Are Associated with Loss Functional and Structural Stability of the Protein.Triose phosphate isomerase from the blood fluke Schistosoma mansoni: biochemical characterisation of a potential drug and vaccine target.Disulfiram as a novel inactivator of Giardia lamblia triosephosphate isomerase with antigiardial potential.Cloning, expression, purification and characterization of his-tagged human glucose-6-phosphate dehydrogenase: a simplified method for protein yield.First characterization of a microsporidial triosephosphate isomerase and the biochemical mechanisms of its inactivation to propose a new druggable target.
P2860
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P2860
Determining the molecular mechanism of inactivation by chemical modification of triosephosphate isomerase from the human parasite Giardia lamblia: a study for antiparasitic drug design
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2011 nî lūn-bûn
@nan
2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
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name
Determining the molecular mech ...... for antiparasitic drug design
@ast
Determining the molecular mech ...... for antiparasitic drug design
@en
Determining the molecular mech ...... for antiparasitic drug design
@nl
type
label
Determining the molecular mech ...... for antiparasitic drug design
@ast
Determining the molecular mech ...... for antiparasitic drug design
@en
Determining the molecular mech ...... for antiparasitic drug design
@nl
prefLabel
Determining the molecular mech ...... for antiparasitic drug design
@ast
Determining the molecular mech ...... for antiparasitic drug design
@en
Determining the molecular mech ...... for antiparasitic drug design
@nl
P2093
P2860
P50
P356
P1433
P1476
Determining the molecular mech ...... for antiparasitic drug design
@en
P2093
Angélica Torres-Arroyo
Gerardo Pérez-Hernández
Gloria Hernández-Alcántara
Ignacio de la Mora-de la Mora
Itzhel García-Torres
Pedro Gutiérrez-Castrellón
Sara T Méndez
Sergio Enríquez-Flores
P2860
P304
P356
10.1002/PROT.23100
P407
P50
P577
2011-07-22T00:00:00Z