Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate - Wikidata - awgldk - TriplyDB

Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate

Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate

http://www.wikidata.org/entity/Q27673339

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Group II p21-activated kinases as therapeutic targets in gastrointestinal cancer The role of p21-activated kinases in hepatocellular carcinoma metastasis PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1 Substrate and Inhibitor Specificity of the Type II p21-Activated Kinase, PAK6 Identification of a Major Determinant for Serine-Threonine Kinase Phosphoacceptor Specificity Signaling, Regulation, and Specificity of the Type II p21-activated Kinases Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain PAK6 targets to cell-cell adhesions through its N-terminus in a Cdc42-dependent manner to drive epithelial colony escape PAK signalling during the development and progression of cancer PAK4 interacts with p85 alpha: implications for pancreatic cancer cell migration Activated-PAK4 predicts worse prognosis in breast cancer and promotes tumorigenesis through activation of PI3K/AKT signaling.The Cdc42 Effector Kinase PAK4 Localizes to Cell-Cell Junctions and Contributes to Establishing Cell Polarity.PAK4 Methylation by SETD6 Promotes the Activation of the Wnt/β-Catenin Pathway.Structural Basis for Noncanonical Substrate Recognition of Cofilin/ADF Proteins by LIM Kinases Regulation of Janus kinases by SOCS proteins.A novel phosphorylation site at Ser130 adjacent to the pseudosubstrate domain contributes to the activation of protein kinase C-δ.P21 activated kinases: structure, regulation, and functions.Structure, biochemistry, and biology of PAK kinases.Functional cross-talk between Cdc42 and two downstream targets, Par6B and PAK4.PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2.CDC42 binds PAK4 via an extended GTPase-effector interface.PAK4 crystal structures suggest unusual kinase conformational movements.Melanoma-associated mutants within the serine-rich domain of PAK5 direct kinase activity to mitogenic pathways.p21-activated kinase signalling in pancreatic cancer: New insights into tumour biology and immune modulation

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P2860

Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate

http://www.wikidata.org/entity/Q27673339

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2012 nî lūn-bûn

@nan

2012 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

name

Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate

@ast

Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate

@en

Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate

@nl

type

label

Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate

@ast

Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate

@en

Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate

@nl

prefLabel

Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate

@ast

Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate

@en

Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate

@nl

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PNAS.1214447109

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate

@en

P2093

Benjamin E Turk

http://www.w3.org/2001/XMLSchema#string

Byung Hak Ha

http://www.w3.org/2001/XMLSchema#string

Catherine Chen

http://www.w3.org/2001/XMLSchema#string

Hua Jane Lou

http://www.w3.org/2001/XMLSchema#string

Jia Gao

http://www.w3.org/2001/XMLSchema#string

Matthew J Davis

http://www.w3.org/2001/XMLSchema#string

Michael Krauthammer

http://www.w3.org/2001/XMLSchema#string

Rong Zhang

http://www.w3.org/2001/XMLSchema#string

Ruth Halaban

http://www.w3.org/2001/XMLSchema#string

Titus J Boggon

http://www.w3.org/2001/XMLSchema#string

P2860

PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia

The emerging importance of group II PAKs

PAK kinases are directly coupled to the PIX family of nucleotide exchange factors

Group I and II mammalian PAKs have different modes of activation by Cdc42

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration

p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD

Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch

Crystal Structures of the p21-Activated Kinases PAK4, PAK5, and PAK6 Reveal Catalytic Domain Plasticity of Active Group II PAKs

Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth

P304

16107-12

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scholarly article

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10.1073/PNAS.1214447109

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P407

P433

40

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P478

109

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P50

Joseph Schlessinger

P577

2012-10-02T00:00:00Z

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P5875

230871876

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22988085

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P932

3479536

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