P21 activated kinases: structure, regulation, and functions.
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Rho GTPase signalling in cell migrationDeciphering the link between PI3K and PAK: An opportunity to target key pathways in pancreatic cancer?Signaling, Regulation, and Specificity of the Type II p21-activated KinasesmicroRNA-126 suppresses PAK4 expression in ovarian cancer SKOV3 cellsp21-activated kinase group II small compound inhibitor GNE-2861 perturbs estrogen receptor alpha signaling and restores tamoxifen-sensitivity in breast cancer cellsPAK6 targets to cell-cell adhesions through its N-terminus in a Cdc42-dependent manner to drive epithelial colony escapeP21-Activated Kinase Inhibitors FRAX486 and IPA3: Inhibition of Prostate Stromal Cell Growth and Effects on Smooth Muscle Contraction in the Human ProstateGastrointestinal hormones/neurotransmitters and growth factors can activate P21 activated kinase 2 in pancreatic acinar cells by novel mechanismsp21-Activated Kinase 4 Promotes Intimal Hyperplasia and Vascular Smooth Muscle Cells Proliferation during Superficial Femoral Artery Restenosis after Angioplasty.P21 activated kinase-1 mediates transforming growth factor β1-induced prostate cancer cell epithelial to mesenchymal transition.FRAX597, a PAK1 inhibitor, synergistically reduces pancreatic cancer growth when combined with gemcitabine.Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex.LIM Kinase, a Newly Identified Regulator of Presynaptic Remodeling by Rod Photoreceptors After Injury.The p21-activated kinase, PAK2, is important in the activation of numerous pancreatic acinar cell signaling cascades and in the onset of early pancreatitis eventsMechanisms of Yersinia YopO kinase substrate specificity.Characterization of a P-Rex1 gene signature in breast cancer cellsPdx1-Cre-driven conditional gene depletion suggests PAK4 as dispensable for mouse pancreas development.Functional role and therapeutic targeting of p21-activated kinase 4 in multiple myeloma.Structure, biochemistry, and biology of PAK kinases.Organization and dynamics of the actin cytoskeleton during dendritic spine morphological remodeling.Structural insights into the intertwined dimer of fyn SH2Expression of p21-activated kinases 1 and 3 is altered in the brain of subjects with depression.Rho GTPases at the crossroad of signaling networks in mammals.Expansion of BCR/ABL1+ cells requires PAK2 but not PAK1.CDC42 binds PAK4 via an extended GTPase-effector interface.Aberrant Rac1-cofilin signaling mediates defects in dendritic spines, synaptic function, and sensory perception in fragile X syndrome.The DNA Methyltransferase 1 (DNMT1) Controls the Shape and Dynamics of Migrating POA-Derived Interneurons Fated for the Murine Cerebral Cortex.miR-29a/b/c function as invasion suppressors for gliomas by targeting CDC42 and predict the prognosis of patients.In silico identification and experimental validation of amino acid motifs required for the Rho-of-plants GTPase-mediated activation of receptor-like cytoplasmic kinases.Group-I PAKs-mediated phosphorylation of HACE1 at serine 385 regulates its oligomerization state and Rac1 ubiquitination.The Anti-Cancer Effects of Frondoside A.Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer.Inhibition of group 1 p21-activated kinases suppresses pancreatic stellate cell activation and increases survival of mice with pancreatic cancer.Structural Characterization of Monomeric/Dimeric State of p59fyn SH2 Domain.Involvement of ARHGEF10, GEF for RhoA, in Rab6/Rab8-mediating membrane traffic.RIT1 controls actin dynamics via complex formation with RAC1/CDC42 and PAK1.p21-activated kinase signalling in pancreatic cancer: New insights into tumour biology and immune modulation
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P21 activated kinases: structure, regulation, and functions.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
P21 activated kinases: structure, regulation, and functions.
@en
type
label
P21 activated kinases: structure, regulation, and functions.
@en
prefLabel
P21 activated kinases: structure, regulation, and functions.
@en
P2860
P356
P1476
P21 activated kinases: structure, regulation, and functions.
@en
P2093
Audrey Minden
Chetan K Rane
P2860
P356
10.4161/SGTP.28003
P577
2014-03-21T00:00:00Z