N-Terminal Acetylation Acts as an Avidity Enhancer Within an Interconnected Multiprotein Complex - Wikidata - awgldk - TriplyDB

N-Terminal Acetylation Acts as an Avidity Enhancer Within an Interconnected Multiprotein Complex

N-Terminal Acetylation Acts as an Avidity Enhancer Within an Interconnected Multiprotein Complex

http://www.wikidata.org/entity/Q27674398

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The NEDD8 modification pathway in plants Structure of a RING E3 trapped in action reveals ligation mechanism for the ubiquitin-like protein NEDD8 α-Synuclein as an intrinsically disordered monomer--fact or artefact?Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover N-Terminal Acetylation-Targeted N-End Rule Proteolytic System: The Ac/N-End Rule Pathway Structure and mechanism of non-histone protein acetyltransferase enzymes N-terminal modifications of cellular proteins: The enzymes involved, their substrate specificities and biological effects Building and remodelling Cullin-RING E3 ubiquitin ligases Structural Conservation of Distinctive N-terminal Acetylation-Dependent Interactions across a Family of Mammalian NEDD8 Ligation Enzymes Molecular basis for N-terminal acetylation by the heterodimeric NatA complex Implications for the evolution of eukaryotic amino-terminal acetyltransferase (NAT) enzymes from the structure of an archaeal ortholog The ROQ domain of Roquin recognizes mRNA constitutive-decay element and double-stranded RNA Nα-acetylated Sir3 stabilizes the conformation of a nucleosome-binding loop in the BAH domain Structural basis for substrate-specific acetylation of Nα-acetyltransferase Ard1 from Sulfolobus solfataricus Multiple Conformations of the Loop Region Confers Heat-Resistance on SsArd1, a Thermophilic NatA N-terminal acetylation by NatC is not a general determinant for substrate subcellular localization in Saccharomyces cerevisiae N-terminal acetylation of the yeast Derlin Der1 is essential for Hrd1 ubiquitin-ligase activity toward luminal ER substrates.Protein N-terminal acetyltransferases act as N-terminal propionyltransferases in vitro and in vivo.Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects A Saccharomyces cerevisiae model reveals in vivo functional impairment of the Ogden syndrome N-terminal acetyltransferase NAA10 Ser37Pro mutant Crystal Structure of the Golgi-Associated Human Nα-Acetyltransferase 60 Reveals the Molecular Determinants for Substrate-Specific Acetylation The molecular basis for histone H4- and H2A-specific amino-terminal acetylation by NatD The biological functions of Naa10 - From amino-terminal acetylation to human disease Naa50/San-dependent N-terminal acetylation of Scc1 is potentially important for sister chromatid cohesion.Fission yeast neddylation ligase Dcn1 facilitates cohesin cleavage and chromosome segregation at anaphase.Structural and functional insights to ubiquitin-like protein conjugation.Protein neddylation: beyond cullin-RING ligases.Protein N-terminal acetyltransferases in cancer.N-acetylation and phosphorylation of Sec complex subunits in the ER membrane Specificity and versatility of substrate binding sites in four catalytic domains of human N-terminal acetyltransferases.Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapy Homeostasis of N-α-terminal acetylation of EsxA correlates with virulence in Mycobacterium marinum.New roles for old modifications: emerging roles of N-terminal post-translational modifications in development and disease.Acetate supplementation as a means of inducing glioblastoma stem-like cell growth arrest Post-translational modification of cardiac proteasomes: functional delineation enabled by proteomics.The STAT3 HIES mutation is a gain-of-function mutation that activates genes via AGG-element carrying promoters NAA10 mutation causing a novel intellectual disability syndrome with Long QT due to N-terminal acetyltransferase impairment.Absence of N-terminal acetyltransferase diversification during evolution of eukaryotic organisms.Substrates of IAP ubiquitin ligases identified with a designed orthogonal E3 ligase, the NEDDylator Positional proteomics reveals differences in N-terminal proteoform stability.

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N-Terminal Acetylation Acts as an Avidity Enhancer Within an Interconnected Multiprotein Complex

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2011 nî lūn-bûn

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2011 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2011 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2011年の論文

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N-terminal acetylation acts as ...... connected multiprotein complex

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Brenda A Schulman

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Daniel C Scott

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Eric J Bennett

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Julie K Monda

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P2860

NatF contributes to an evolutionary shift in protein N-terminal acetylation and is important for normal chromosome segregation

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8

The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae

Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation

E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification

SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation

NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases

CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex

Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival

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10.1126/SCIENCE.1209307

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6056

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334

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Jeffrey W. Harper

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2011-09-22T00:00:00Z

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51664360

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21940857

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3214010

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