Structural basis of ligand recognition in 5-HT3 receptors - Wikidata - awgldk - TriplyDB

Structural basis of ligand recognition in 5-HT3 receptors

Structural basis of ligand recognition in 5-HT3 receptors

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Ion channels gated by acetylcholine and serotonin: structures, biology, and drug discovery Principles of agonist recognition in Cys-loop receptors Functional probes of drug-receptor interactions implicated by structural studies: Cys-loop receptors provide a fertile testing ground Escherichia coli Protein Expression System for Acetylcholine Binding Proteins (AChBPs)The binding orientations of structurally-related ligands can differ; A cautionary note The binding characteristics and orientation of a novel radioligand with distinct properties at 5-HT3A and 5-HT3AB receptors Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms αS-conotoxin GVIIIB potently and selectively blocks α9α10 nicotinic acetylcholine receptors.High yield and efficient expression and purification of the human 5-HT3A receptor The muscarinic antagonists scopolamine and atropine are competitive antagonists at 5-HT3 receptors.Identifying key amino acid residues that affect α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors.Noncompetitive Inhibition of 5-HT3 Receptors by Citral, Linalool, and Eucalyptol Revealed by Nonlinear Mixed-Effects Modeling.The evolution of pentameric ligand-gated ion-channels and the changing family of anthelmintic drug targets.Structural Studies of Nicotinic Acetylcholine Receptors: Using Acetylcholine-Binding Protein as a Structural Surrogate.Varenicline Interactions at the 5-HT3 Receptor Ligand Binding Site are Revealed by 5-HTBP Trapping of ivermectin by a pentameric ligand-gated ion channel upon open-to-closed isomerization.Mutational Analysis at Intersubunit Interfaces of an Anionic Glutamate Receptor Reveals a Key Interaction Important for Channel Gating by Ivermectin.Novel mechanism of modulation at a ligand-gated ion channel; action of 5-Cl-indole at the 5-HT3 A receptor.Association between variants of 5-hydroxytryptamine receptor 3C (HTR3C) and chemotherapy-induced symptoms in women receiving adjuvant treatment for breast cancer.

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Structural basis of ligand recognition in 5-HT3 receptors

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2013 nî lūn-bûn

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2013 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2013年の論文

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2013年論文

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2013年論文

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name

Structural basis of ligand recognition in 5-HT3 receptors

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Structural basis of ligand recognition in 5-HT3 receptors

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Structural basis of ligand recognition in 5-HT3 receptors

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Structural basis of ligand recognition in 5-HT3 receptors

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Structural basis of ligand recognition in 5-HT3 receptors

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Structural basis of ligand recognition in 5-HT3 receptors

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Structural basis of ligand recognition in 5-HT3 receptors

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Structural basis of ligand recognition in 5-HT3 receptors

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Structural basis of ligand recognition in 5-HT3 receptors

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Structural basis of ligand recognition in 5-HT3 receptors

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Albert Guskov

http://www.w3.org/2001/XMLSchema#string

Andrew J Thompson

http://www.w3.org/2001/XMLSchema#string

August B Smit

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Chris Ulens

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Divya Kesters

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Jose M Villalgordo

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Marijke Brams

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Matthis Geitmann

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Radovan Spurny

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René van Elk

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P2860

A structural and mutagenic blueprint for molecular recognition of strychnine and d-tubocurarine by different cys-loop receptors

Effects of serotonergic agents on neuronal nicotinic acetylcholine receptors

5-HT3 receptors

The 5-HT3 receptor as a therapeutic target

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

Cation-pi interactions in ligand recognition by serotonergic (5-HT3A) and nicotinic acetylcholine receptors: the anomalous binding properties of nicotine

The expanded biology of serotonin.

Varenicline is a potent agonist of the human 5-hydroxytryptamine3 receptor.

A hydrogen bond in loop A is critical for the binding and function of the 5-HT3 receptor.

5-Fluorotryptamine is a partial agonist at 5-HT3 receptors, and reveals that size and electronegativity at the 5 position of tryptamine are critical for efficient receptor function.

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49-56

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776048

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10.1038/EMBOR.2012.189

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1

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14

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23196367

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