A structural and mutagenic blueprint for molecular recognition of strychnine and d-tubocurarine by different cys-loop receptors - Wikidata - awgldk - TriplyDB

A structural and mutagenic blueprint for molecular recognition of strychnine and d-tubocurarine by different cys-loop receptors

A structural and mutagenic blueprint for molecular recognition of strychnine and d-tubocurarine by different cys-loop receptors

http://www.wikidata.org/entity/Q21145775

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Size matters in activation/inhibition of ligand-gated ion channels Glycine receptor mechanism elucidated by electron cryo-microscopy.Crystal Structure of Lymnaea stagnalis AChBP Complexed with the Potent nAChR Antagonist DHβE Suggests a Unique Mode of Antagonism Insights into the structural determinants required for high-affinity binding of chiral cyclopropane-containing ligands to α4β2-nicotinic acetylcholine receptors: an integrated approach to behaviorally active nicotinic ligands.Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines Structural basis of ligand recognition in 5-HT3 receptors Intersubunit Bridge Formation Governs Agonist Efficacy at Nicotinic Acetylcholine 4 2 Receptors: UNIQUE ROLE OF HALOGEN BONDING REVEALED Structure of the pentameric ligand-gated ion channel ELIC cocrystallized with its competitive antagonist acetylcholine Assembly of a π–π stack of ligands in the binding site of an acetylcholine-binding protein Molecular actions of smoking cessation drugs at 4 2 nicotinic receptors defined in crystal structures of a homologous binding protein Crystal structure of human glycine receptor-α3 bound to antagonist strychnine Ethanol effects on glycinergic transmission: From molecular pharmacology to behavior responses Murine startle mutant Nmf11 affects the structural stability of the glycine receptor and increases deactivation.Glycine receptor mouse mutants: model systems for human hyperekplexia Catch-and-hold activation of muscle acetylcholine receptors having transmitter binding site mutations Identification of novel α7 nicotinic receptor ligands by in silico screening against the crystal structure of a chimeric α7 receptor ligand binding domain The binding characteristics and orientation of a novel radioligand with distinct properties at 5-HT3A and 5-HT3AB receptors Disturbed neuronal ER-Golgi sorting of unassembled glycine receptors suggests altered subcellular processing is a cause of human hyperekplexia.Marine natural products acting on the acetylcholine-binding protein and nicotinic receptors: from computer modeling to binding studies and electrophysiology.Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor.An integrated catch-and-hold mechanism activates nicotinic acetylcholine receptors.A chimeric prokaryotic pentameric ligand-gated channel reveals distinct pathways of activation.High Throughput Random Mutagenesis and Single Molecule Real Time Sequencing of the Muscle Nicotinic Acetylcholine Receptor Action of nicotine and analogs on acetylcholine receptors having mutations of transmitter-binding site residue αG153 Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors.Loop C and the mechanism of acetylcholine receptor-channel gating.Activation of the α7 nicotinic ACh receptor induces anxiogenic effects in rats which is blocked by a 5-HT₁a receptor antagonist.Effects of neuronal nicotinic acetylcholine receptor allosteric modulators in animal behavior studies.Allosteric binding site in a Cys-loop receptor ligand-binding domain unveiled in the crystal structure of ELIC in complex with chlorpromazine High-Affinity α-Conotoxin PnIA Analogs Designed on the Basis of the Protein Surface Topography Method.Optochemical genetics.Alpha7 neuronal nicotinic receptors as a drug target in schizophrenia.Natural compounds interacting with nicotinic acetylcholine receptors: from low-molecular weight ones to peptides and proteins.Structural Studies of Nicotinic Acetylcholine Receptors: Using Acetylcholine-Binding Protein as a Structural Surrogate.Understanding structure-function relationships of the human neuronal acetylcholine receptor: insights from the first crystal structures of neuronal subunits.Design of new α-conotoxins: from computer modeling to synthesis of potent cholinergic compounds.Varenicline Interactions at the 5-HT3 Receptor Ligand Binding Site are Revealed by 5-HTBP Enhanced meta-analysis of acetylcholine binding protein structures reveals conformational signatures of agonism in nicotinic receptors.Disturbances of Ligand Potency and Enhanced Degradation of the Human Glycine Receptor at Affected Positions G160 and T162 Originally Identified in Patients Suffering from Hyperekplexia.The GlyR Extracellular β8-β9 Loop - A Functional Determinant of Agonist Potency.

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A structural and mutagenic blueprint for molecular recognition of strychnine and d-tubocurarine by different cys-loop receptors

http://www.wikidata.org/entity/Q21145775

description

2011 nî lūn-bûn

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2011 թուականի Մարտին հրատարակուած գիտական յօդուած

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2011 թվականի մարտին հրատարակված գիտական հոդված

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2011年論文

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2011年论文

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A structural and mutagenic blu ...... y different cys-loop receptors

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A structural and mutagenic blu ...... y different cys-loop receptors

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A structural and mutagenic blu ...... y different cys-loop receptors

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A structural and mutagenic blu ...... y different cys-loop receptors

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Anshul Pandya

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August B Smit

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Chris Ulens

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Jerrel L Yakel

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Liz Krijnen

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Marijke Brams

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René van Elk

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Victor Tsetlin

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P2860

The beta subunit determines the ligand binding properties of synaptic glycine receptors

Alpha subunit variants of the human glycine receptor: primary structures, functional expression and chromosomal localization of the corresponding genes

Crystal structure of the extracellular domain of nAChR alpha1 bound to alpha-bungarotoxin at 1.94 A resolution

Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal α7 nicotinic acetylcholine receptor

Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations

Glycine receptor heterogeneity in rat spinal cord during postnatal development

Structural features of the ligand-binding domain of the serotonin 5HT3 receptor

Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures

[(3)H]Epibatidine photolabels non-equivalent amino acids in the agonist binding site of Torpedo and alpha4beta2 nicotinic acetylcholine receptors

Structural determinants of selective alpha-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP.

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