The crystal structure of human endoplasmic reticulum aminopeptidase 2 reveals the atomic basis for distinct roles in antigen processing
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Antigenic peptide trimming by ER aminopeptidases--insights from structural studiesA Common Single Nucleotide Polymorphism in Endoplasmic Reticulum Aminopeptidase 2 Induces a Specificity Switch That Leads to Altered Antigen ProcessingThe X-ray Crystal Structure of Human Aminopeptidase N Reveals a Novel Dimer and the Basis for Peptide ProcessingA Naturally Variable Residue in the S1 Subsite of M1 Family Aminopeptidases Modulates Catalytic Properties and Promotes Functional SpecializationRationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responsesThe MORPHEUS II protein crystallization screenThe genetic basis of ankylosing spondylitis: new insights into disease pathogenesisUpdate on ankylosing spondylitis: current concepts in pathogenesis.A role for naturally occurring alleles of endoplasmic reticulum aminopeptidases in tumor immunity and cancer pre-disposition.Concerted in vitro trimming of viral HLA-B27-restricted ligands by human ERAP1 and ERAP2 aminopeptidases.Structural Basis for Antigenic Peptide Recognition and Processing by Endoplasmic Reticulum (ER) Aminopeptidase 2Screening Identifies Thimerosal as a Selective Inhibitor of Endoplasmic Reticulum Aminopeptidase 1.ERAP1-ERAP2 dimers trim MHC I-bound precursor peptides; implications for understanding peptide editing.Monitoring peptide processing for MHC class I molecules in the endoplasmic reticulum.Advances in the genetics of spondyloarthritis and clinical implications.Positioning of aminopeptidase inhibitors in next generation cancer therapy.Genetic associations and functional characterization of M1 aminopeptidases and immune-mediated diseases.The Human Leukocyte Antigen (HLA)-B27 Peptidome in Vivo, in Spondyloarthritis-susceptible HLA-B27 Transgenic Rats and the Effect of Erap1 Deletion.Endoplasmic reticulum aminopeptidases in the pathogenesis of ankylosing spondylitis.Functional Interaction of the Ankylosing Spondylitis-Associated Endoplasmic Reticulum Aminopeptidase 2 With the HLA-B*27 Peptidome in Human Cells.New insights toward the pathogenesis of ankylosing spondylitis; genetic variations and epigenetic modifications.M1 aminopeptidases as drug targets: broad applications or therapeutic niche?Functional interaction of the ankylosing spondylitis-associated endoplasmic reticulum aminopeptidase 1 polymorphism and HLA-B27 in vivo.The interplay between HLA-B27 and ERAP1/ERAP2 aminopeptidases: from anti-viral protection to spondyloarthritis.The Role of Conformational Dynamics in Antigen Trimming by Intracellular Aminopeptidases.Modeling of human M1 aminopeptidases for in silico screening of potential Plasmodium falciparum alanine aminopeptidase (PfA-M1) specific inhibitors.Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides.Crystal structure of a polypeptide's C-terminus in complex with the regulatory domain of ER aminopeptidase 1.Crystal Structures of ERAP2 Complexed with Inhibitors Reveal Pharmacophore Requirements for Optimizing Inhibitor Potency.ERAP1 and HLA-C interaction in inflammatory bowel disease in the Spanish population.How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I Proteins
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P2860
The crystal structure of human endoplasmic reticulum aminopeptidase 2 reveals the atomic basis for distinct roles in antigen processing
description
2012 nî lūn-bûn
@nan
2012 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
The crystal structure of human ...... ct roles in antigen processing
@ast
The crystal structure of human ...... ct roles in antigen processing
@en
The crystal structure of human ...... ct roles in antigen processing
@nl
type
label
The crystal structure of human ...... ct roles in antigen processing
@ast
The crystal structure of human ...... ct roles in antigen processing
@en
The crystal structure of human ...... ct roles in antigen processing
@nl
prefLabel
The crystal structure of human ...... ct roles in antigen processing
@ast
The crystal structure of human ...... ct roles in antigen processing
@en
The crystal structure of human ...... ct roles in antigen processing
@nl
P2093
P3181
P356
P1433
P1476
The crystal structure of human ...... ct roles in antigen processing
@en
P2093
Emmanuel Saridakis
Irene M Mavridis
James R Birtley
P304
P3181
P356
10.1021/BI201230P
P407
P577
2011-12-09T00:00:00Z