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Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1The crystal structure of human endoplasmic reticulum aminopeptidase 2 reveals the atomic basis for distinct roles in antigen processingRationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responsesCrystal Structure of Insulin-Regulated Aminopeptidase with Bound Substrate Analogue Provides Insight on Antigenic Epitope Precursor Recognition and ProcessingThe internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1.Molecular basis for increased risk for late-onset Alzheimer disease due to the naturally occurring L28P mutation in apolipoprotein E4.Endoplasmic reticulum aminopeptidase-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens.Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1The Pivotal Role of Protein Phosphorylation in the Control of Yeast Central MetabolismA role for naturally occurring alleles of endoplasmic reticulum aminopeptidases in tumor immunity and cancer pre-disposition.Regulating adaptive immune responses using small molecule modulators of aminopeptidases that process antigenic peptides.Autoimmune disease-associated variants of extracellular endoplasmic reticulum aminopeptidase 1 induce altered innate immune responses by human immune cells.Structural Basis for Antigenic Peptide Recognition and Processing by Endoplasmic Reticulum (ER) Aminopeptidase 2Human cytomegalovirus microRNA miR-US4-1 inhibits CD8(+) T cell responses by targeting the aminopeptidase ERAP1Allele-dependent thermodynamic and structural perturbations in ApoE variants associated with the correction of dyslipidemia and formation of spherical ApoE-containing HDL particles.Structural similarity of the covalent complexes formed between the serpin plasminogen activator inhibitor-1 and the arginine-specific proteinases trypsin, LMW u-PA, HMW u-PA, and t-PA: use of site-specific fluorescent probes of local environmentScreening Identifies Thimerosal as a Selective Inhibitor of Endoplasmic Reticulum Aminopeptidase 1.The ability of apolipoprotein E fragments to promote intraneuronal accumulation of amyloid beta peptide 42 is both isoform and size-specific.A Novel ERAP2 Haplotype Structure in a Chilean Population: Implications for ERAP2 Protein Expression and Preeclampsia Risk.Significance of the hydrophobic residues 225-230 of apoA-I for the biogenesis of HDL.A new role for Zn(II) aminopeptidases: antigenic peptide generation and destruction.Modulating antigen processing for cancer immunotherapy.Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides.A possible structural basis behind the pathogenic role of apolipoprotein E hereditary mutations associated with lipoprotein glomerulopathy.Critical Role of Interdomain Interactions in the Conformational Change and Catalytic Mechanism of Endoplasmic Reticulum Aminopeptidase 1.Optimization and Structure-Activity Relationships of Phosphinic Pseudotripeptide Inhibitors of Aminopeptidases That Generate Antigenic Peptides.3,4-diaminobenzoic acid derivatives as inhibitors of the oxytocinase subfamily of M1 aminopeptidases with immune-regulating properties.A simple approach for human recombinant apolipoprotein E4 expression and purification.Identification of the lateral interaction surfaces of human histocompatibility leukocyte antigen (HLA)-DM with HLA-DR1 by formation of tethered complexes that present enhanced HLA-DM catalysisEffects of polymorphic variation on the mechanism of Endoplasmic Reticulum Aminopeptidase 1.The Role of Conformational Dynamics in Antigen Trimming by Intracellular Aminopeptidases.Novel selective inhibitors of aminopeptidases that generate antigenic peptides.A continuous fluorigenic assay for the measurement of the activity of endoplasmic reticulum aminopeptidase 1: competition kinetics as a tool for enzyme specificity investigation.A novel ERAP2 haplotype structure in a Chilean population: implications for ERAP2 protein expression and preeclampsia risk.Mapping the serpin-proteinase complex using single cysteine variants of alpha1-proteinase inhibitor Pittsburgh.Ligand-Induced Conformational Change of Insulin-Regulated Aminopeptidase: Insights on Catalytic Mechanism and Active Site Plasticity.Inhibitors of ER aminopeptidase 1 and 2: from design to clinical application.The role of Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) in modulating immune detection of choriocarcinoma.Molecular pathways for antigenic peptide generation by ER aminopeptidase 1.Enhanced catalytic action of HLA-DM on the exchange of peptides lacking backbone hydrogen bonds between their N-terminal region and the MHC class II alpha-chain.
P50
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P50
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hulumtues
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հետազոտող
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Efstratios Stratikos
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Efstratios Stratikos
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Efstratios Stratikos
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Efstratios Stratikos
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Efstratios Stratikos
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Efstratios Stratikos
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Efstratios Stratikos
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P1053
N-2969-2014
P106
P1153
6603120862
P21
P2798
P31
P3829
P496
0000-0002-3566-2309