Somatic hypermutation maintains antibody thermodynamic stability during affinity maturation
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Ontogeny of recognition specificity and functionality for the broadly neutralizing anti-HIV antibody 4E10Reshaping Antibody DiversitySomatic Hypermutation-Induced Changes in the Structure and Dynamics of HIV-1 Broadly Neutralizing AntibodiesIntegrating multiple immunogenetic data sources for feature extraction and mining somatic hypermutation patterns: the case of "towards analysis" in chronic lymphocytic leukaemia.Addressing polyspecificity of antibodies selected from an in vitro yeast presentation system: a FACS-based, high-throughput selection and analytical tool.Prevalence and gene characteristics of antibodies with cofactor-induced HIV-1 specificity.Overlapping hotspots in CDRs are critical sites for V region diversificationGeneration of an intrabody-based reagent suitable for imaging endogenous proliferating cell nuclear antigen in living cancer cells.Broad blockade antibody responses in human volunteers after immunization with a multivalent norovirus VLP candidate vaccine: immunological analyses from a phase I clinical trialOptimizing antibody expression by using the naturally occurring framework diversity in a live bacterial antibody display systemAutopolyreactivity Confers a Holistic Role in the Immune System.Co-evolution of affinity and stability of grafted amyloid-motif domain antibodies.Tuning the specificity of a Two-in-One Fab against three angiogenic antigens by fully utilizing the information of deep mutational scanning.An antibody with a variable-region coiled-coil "knob" domain.The rapid generation of recombinant functional monoclonal antibodies from individual, antigen-specific bone marrow-derived plasma cells isolated using a novel fluorescence-based method.Mutational landscape of antibody variable domains reveals a switch modulating the interdomain conformational dynamics and antigen binding.Biophysical properties of the clinical-stage antibody landscape.Efficient affinity maturation of antibody variable domains requires co-selection of compensatory mutations to maintain thermodynamic stability.NALDB: nucleic acid ligand database for small molecules targeting nucleic acid.Directed evolution of anti-HER2 DARPins by SNAP display reveals stability/function trade-offs in the selection processA novel antibody discovery platform identifies anti-influenza A broadly neutralizing antibodies from human memory B cells.Increased exposure to Plasmodium chabaudi antigens sustains cross-reactivity and avidity of antibodies binding Nippostrongylus brasiliensis: dissecting cross-phylum cross-reactivity in a rodent model.The role of Antibody Vκ Framework 3 region towards Antigen binding: Effects on recombinant production and Protein L binding.Introduction of germline residues improves the stability of anti-HIV mAb 2G12-IgMFacile Affinity Maturation of Antibody Variable Domains Using Natural Diversity Mutagenesis.Rigidity Emerges during Antibody Evolution in Three Distinct Antibody Systems: Evidence from QSFR Analysis of Fab Fragments.A general approach to antibody thermostabilization.Rapid development of broadly influenza neutralizing antibodies through redundant mutations.Mutational analysis of 48G7 reveals that somatic hypermutation affects both antibody stability and binding affinityPrinciples for computational design of binding antibodies.Integrity of immunoglobulin variable regions is supported by GANP during AID-induced somatic hypermutation in germinal center B cells.Reduction of Nonspecificity Motifs in Synthetic Antibody Libraries.Thermodynamic analyses of amino acid residues at the interface of an antibody B2212A and its antigen roundabout homolog 1.Arginine mutations in antibody complementarity-determining regions display context-dependent affinity/specificity trade-offs.Insights into the Structural Basis of Antibody Affinity Maturation from Next-Generation Sequencing.Improving the developability of an anti-EphA2 single-chain variable fragment for nanoparticle targeting.In Vitro Evolution of Antibodies Inspired by In Vivo Evolution.
P2860
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P2860
Somatic hypermutation maintains antibody thermodynamic stability during affinity maturation
description
2013 nî lūn-bûn
@nan
2013 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի մարտին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Somatic hypermutation maintain ...... ity during affinity maturation
@ast
Somatic hypermutation maintain ...... ity during affinity maturation
@en
Somatic hypermutation maintain ...... ity during affinity maturation
@nl
type
label
Somatic hypermutation maintain ...... ity during affinity maturation
@ast
Somatic hypermutation maintain ...... ity during affinity maturation
@en
Somatic hypermutation maintain ...... ity during affinity maturation
@nl
prefLabel
Somatic hypermutation maintain ...... ity during affinity maturation
@ast
Somatic hypermutation maintain ...... ity during affinity maturation
@en
Somatic hypermutation maintain ...... ity during affinity maturation
@nl
P2093
P2860
P3181
P356
P1476
Somatic hypermutation maintain ...... ity during affinity maturation
@en
P2093
Insha Ahmad
Peter G Schultz
Shiladitya Sen
Thomas J Magliery
Vaughn V Smider
Xueyong Zhu
Yong Zhang
P2860
P304
P3181
P356
10.1073/PNAS.1301810110
P407
P577
2013-03-12T00:00:00Z