A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A - Wikidata - awgldk - TriplyDB

A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A

A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A

http://www.wikidata.org/entity/Q27676768

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Drugging MYCN through an allosteric transition in Aurora kinase A Development of o -Chlorophenyl Substituted Pyrimidines as Exceptionally Potent Aurora Kinase Inhibitors A Novel Approach to the Discovery of Small-Molecule Ligands of CDK2 Development of Highly Potent and Selective Diaminothiazole Inhibitors of Cyclin-Dependent Kinases Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules Sequence Determinants of a Specific Inactive Protein Kinase Conformation Base-modified Donor Analogues Reveal Novel Dynamic Features of a Glycosyltransferase Molecular mechanism of Aurora A kinase autophosphorylation and its allosteric activation by TPX2 Development of novel ACK1/TNK2 inhibitors using a fragment-based approach Identification and Characterization of an Irreversible Inhibitor of CDK2.An update on the pharmacokinetics and pharmacodynamics of alisertib, a selective Aurora kinase A inhibitor.Basal aurora kinase B activity is sufficient for histone H3 phosphorylation in prophase A water-mediated allosteric network governs activation of Aurora kinase A.Specificity rendering 'hot-spots' for aurora kinase inhibitor design: the role of non-covalent interactions and conformational transitions.Long residence times revealed by Aurora A kinase-targeting fluorescent probes derived from inhibitors MLN8237 and VX-689.A mixed DFT-MD methodology for the in silico development of drug releasing macrocycles. Calix and thia-calix[N]arenes as carriers for Bosutinib and Sorafenib.The multifaceted allosteric regulation of Aurora kinase A.Dynamics of human protein kinase Aurora A linked to drug selectivity

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A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A

http://www.wikidata.org/entity/Q27676768

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2012 nî lūn-bûn

@nan

2012 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A

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A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A

@en

A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A

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type

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A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A

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A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A

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A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A

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prefLabel

A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A

@ast

A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A

@en

A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A

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ACS Chemical Biology

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A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A

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Ernst Schönbrunn

http://www.w3.org/2001/XMLSchema#string

Harshani R Lawrence

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Jin-Yi Zhu

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Mathew P Martin

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Nicholas J Lawrence

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Riazul Alam

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Roberta Pireddu

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Said M Sebti

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Sevil Ozcan

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Yunting Luo

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P2860

The structure of CDK8/CycC implicates specificity in the CDK/cyclin family and reveals interaction with a deep pocket binder

Halogen bonds in biological molecules

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

Two TPX2-dependent switches control the activity of Aurora A

Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site

Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571)

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698-706

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scholarly article

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10.1021/CB200508B

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4

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7

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2012-04-20T00:00:00Z

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221750536

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22248356

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4429595

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