A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage
about
Elucidation of the binding preferences of peptide recognition modules: SH3 and PDZ domainsExtending the translational potential of targeting NO/cGMP-regulated pathways in the CVSEndogenous IFN-β signaling exerts anti-inflammatory actions in experimentally induced focal cerebral ischemiaDesign and synthesis of high-affinity dimeric inhibitors targeting the interactions between gephyrin and inhibitory neurotransmitter receptorsMolecular basis of the alternative recruitment of GABA(A) versus glycine receptors through gephyrinTargeting protein-protein interactions with trimeric ligands: high affinity inhibitors of the MAGUK protein familyAccidental interaction between PDZ domains and diclofenac revealed by NMR-assisted virtual screening.IL1R9 Is Evolutionarily Related to IL18BP and May Function as an IL-18 Receptor.Reconstitution of multivalent PDZ domain binding to the scaffold protein PSD-95 reveals ternary-complex specificity of combinatorial inhibitionEfficacy of the PSD95 inhibitor Tat-NR2B9c in mice requires dose translation between species.Postsynaptic scaffold protein Homer 1a protects against traumatic brain injury via regulating group I metabotropic glutamate receptors.Genetic KCa3.1-deficiency produces locomotor hyperactivity and alterations in cerebral monoamine levelsEfficacy and safety of mildronate for acute ischemic stroke: a randomized, double-blind, active-controlled phase II multicenter trial.Progressive brain damage, synaptic reorganization and NMDA activation in a model of epileptogenic cortical dysplasia.Rigidified clicked dimeric ligands for studying the dynamics of the PDZ1-2 supramodule of PSD-95.Design of a PDZbody, a bivalent binder of the E6 protein from human papillomavirusLigand binding to the PDZ domains of postsynaptic density protein 95.Scaffolding protein Homer1a protects against NMDA-induced neuronal injury.Design and characterization of bivalent BET inhibitors.Cell therapy centered on IL-1Ra is neuroprotective in experimental stroke.Membrane-permeable C-terminal dopamine transporter peptides attenuate amphetamine-evoked dopamine release.Plasticity of PDZ domains in ligand recognition and signaling.Ligand binding by PDZ domains.The emerging contribution of sequence context to the specificity of protein interactions mediated by PDZ domains.Scaffolding proteins of the post-synaptic density contribute to synaptic plasticity by regulating receptor localization and distribution: relevance for neuropsychiatric diseases.Influence of GluN2 subunit identity on NMDA receptor function.Structures and target recognition modes of PDZ domains: recurring themes and emerging pictures.The glutamatergic aspects of schizophrenia molecular pathophysiology: role of the postsynaptic density, and implications for treatmentEffects of Dimeric PSD-95 Inhibition on Excitotoxic Cell Death and Outcome After Controlled Cortical Impact in Rats.Posttranslational Modifications Regulate the Postsynaptic Localization of PSD-95.In vitro and in vivo effects of a novel dimeric inhibitor of PSD-95 on excitotoxicity and functional recovery after experimental traumatic brain injury.Organization and functions of mGlu and GABAB receptor complexes.Protein kinase A-phosphorylated KV1 channels in PSD95 signaling complex contribute to the resting membrane potential and diameter of cerebral arteriesBiochemical investigations of the mechanism of action of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ/PSD-95-PDZ interactions.Novel drug target identification for the treatment of dementia using multi-relational association mining.Genetic ablation of soluble tumor necrosis factor with preservation of membrane tumor necrosis factor is associated with neuroprotection after focal cerebral ischemia.NOS knockout or inhibition but not disrupting PSD-95-NOS interaction protect against ischemic brain damage.Combining Graphical and Analytical Methods with Molecular Simulations To Analyze Time-Resolved FRET Measurements of Labeled Macromolecules AccuratelySimultaneous prediction of binding free energy and specificity for PDZ domain-peptide interactions.Novel microscale approaches for easy, rapid determination of protein stability in academic and commercial settings.
P2860
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P2860
A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage
description
2012 nî lūn-bûn
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2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
A high-affinity, dimeric inhib ...... against ischemic brain damage
@ast
A high-affinity, dimeric inhib ...... against ischemic brain damage
@en
A high-affinity, dimeric inhib ...... against ischemic brain damage
@nl
type
label
A high-affinity, dimeric inhib ...... against ischemic brain damage
@ast
A high-affinity, dimeric inhib ...... against ischemic brain damage
@en
A high-affinity, dimeric inhib ...... against ischemic brain damage
@nl
prefLabel
A high-affinity, dimeric inhib ...... against ischemic brain damage
@ast
A high-affinity, dimeric inhib ...... against ischemic brain damage
@en
A high-affinity, dimeric inhib ...... against ischemic brain damage
@nl
P2093
P2860
P50
P356
P1476
A high-affinity, dimeric inhib ...... against ischemic brain damage
@en
P2093
Celestine N Chi
Klaus B Nissen
Magda Møller
Patrik Lundström
Pernille L Sørensen
P2860
P304
P356
10.1073/PNAS.1113761109
P407
P50
P577
2012-02-28T00:00:00Z