Fluorescence polarization competition assay: the range of resolvable inhibitor potency is limited by the affinity of the fluorescent ligand.
about
In vitro screening and structural characterization of inhibitors of the S100B-p53 interactionSmall-Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1αA high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damageDesign of Bcl-2 and Bcl-xL Inhibitors with Subnanomolar Binding Affinities Based upon a New ScaffoldDiscovery of direct inhibitors of Keap1-Nrf2 protein-protein interaction as potential therapeutic and preventive agentsTargeting protein-protein interactions with trimeric ligands: high affinity inhibitors of the MAGUK protein familyInvestigating Apoptozole as a Chemical Probe for HSP70 InhibitionDual Screening of BPTF and Brd4 Using Protein-Observed Fluorine NMR Uncovers New Bromodomain Probe MoleculesA high throughput fluorescence polarization assay for inhibitors of the GoLoco motif/G-alpha interaction.A high-throughput screening fluorescence polarization assay for fatty acid adenylating enzymes in Mycobacterium tuberculosis.Exploiting ligand-protein conjugates to monitor ligand-receptor interactions.In silico structure-based screening of versatile P-glycoprotein inhibitors using polynomial empirical scoring functions.Three-dimensional quantitative structure-activity relationship and docking studies in a series of anthocyanin derivatives as cytochrome P450 3A4 inhibitorsBiophysical screening for the discovery of small-molecule ligands.Exploiting the P-1 pocket of BRCT domains toward a structure guided inhibitor design.Fluorescence polarization assays in small molecule screening.Optimization of fluorescently labeled Nrf2 peptide probes and the development of a fluorescence polarization assay for the discovery of inhibitors of Keap1-Nrf2 interaction.Discovery of the first small-molecule CsrA-RNA interaction inhibitors using biophysical screening technologies.Structure-based design of potent Bcl-2/Bcl-xL inhibitors with strong in vivo antitumor activity.Structure-based discovery of BM-957 as a potent small-molecule inhibitor of Bcl-2 and Bcl-xL capable of achieving complete tumor regressionFörster resonance energy transfer competitive displacement assay for human soluble epoxide hydrolase.Quantitative analysis of histone demethylase probes using fluorescence polarizationAryl acid adenylating enzymes involved in siderophore biosynthesis: fluorescence polarization assay, ligand specificity, and discovery of non-nucleoside inhibitors via high-throughput screening.IC50-to-Ki: a web-based tool for converting IC50 to Ki values for inhibitors of enzyme activity and ligand bindingA Fluorescence Polarization Biophysical Assay for the Naegleria DNA Hydroxylase Tet1.Displacement of protein-bound aptamers with small molecules screened by fluorescence polarization.Selective Inhibition of CBX6: A Methyllysine Reader Protein in the Polycomb FamilyBET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen.FP Tethering: a screening technique to rapidly identify compounds that disrupt protein-protein interactions.Interrogation of phosphor-specific interaction on a high-throughput label-free optical biosensor system-Epic system.Fluorescence polarization assays in high-throughput screening and drug discovery: a reviewA fluorescence polarization assay for identifying ligands that bind to vascular endothelial growth factor.Application of Fluorescence Polarization in HTS Assays.An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56A fast, open source implementation of adaptive biasing potentials uncovers a ligand design strategy for the chromatin regulator BRD4.Mapping Protein-Protein Interactions of the Resistance-Related Bacterial Zeta Toxin-Epsilon Antitoxin Complex (ε₂ζ₂) with High Affinity Peptide Ligands Using Fluorescence Polarization.Design, synthesis, and pharmacology of fluorescently labeled analogs of serotonin: application to screening of the 5-HT2C receptor.Design and synthesis of highly potent and plasma-stable dimeric inhibitors of the PSD-95-NMDA receptor interaction.Development of biochemical assays for the identification of eIF4E-specific inhibitors.Investigation of heavy metal effects on immobilized paraoxanase by glutaraldehyde.
P2860
Q27666186-10E14914-6148-4708-84F2-FD720201A066Q27674529-363FBE40-475F-44FE-97CE-90B95581A3EDQ27677328-B93648B9-1085-42D8-8EAE-F820E615435EQ27678209-0D6E7408-6434-4629-B2B7-95A936D13CDFQ28085561-D2EA27A7-0B96-47DC-B5E4-1329B4572FEEQ28543254-62CD683F-0338-439D-B57F-907F43824ED2Q28550180-215CE03D-2079-4B90-8DD2-481B2B73853CQ28833420-FC10D8DE-CD61-4A5C-8D5D-E81E674A4B64Q33341121-6B340E8C-8691-4F4E-8104-975A1EE66EF5Q33965669-999B222E-26C0-4486-B498-FC709590321DQ34304983-DFC15248-93A9-4E95-A9FF-1C2A2A93B5DFQ34414201-314B4C7F-5975-4ACA-839B-46E9C8460960Q34415634-D6AC8357-318D-4E06-84A5-125DFFCE3D65Q34752496-882FAFC3-090A-4831-8BA5-F7C28005999EQ35445886-A4707D56-FA7A-440A-99E2-9BD7ECB189BBQ35750597-83C5C096-0470-4C6D-AAD3-1399D4721DA4Q35842879-447F560C-9619-4B93-B342-7DE2930197E7Q36038055-AB6A587A-03CC-40B4-A4F8-11C2CB5FC449Q36158350-8D73FF82-D6DC-4279-8677-3C5C2EB7647BQ36390326-7F1FC8BA-BBA0-4E87-AF96-558639351B2FQ36784547-FE7C46CE-F596-4DB4-B4C0-FB2158002A80Q37048764-5FDE23A8-E3D0-41FD-A2E0-55698CDC539FQ37125144-F83FEF18-3658-4B24-9265-95EE0CEB8C9CQ37245607-ACB60003-D58C-4E27-9B58-0165ED89FCF5Q37480128-B65FCCBD-077A-4DB7-944A-AC8182945463Q38292056-2A174C7B-8414-45F5-958C-FCA95CF15CEBQ38434032-EEB0C75C-F903-4356-B33C-1A60D1DF179FQ38702568-F78B94E5-0002-49DE-BBF1-F568CEF29ADBQ39085729-6925428C-EDB1-4FF3-A4C1-CA55E9498CBEQ39819353-7D92F213-C042-4EF5-B3DD-85AD4B58FC43Q41467248-F69E51D2-2E6E-4EC0-BC6E-D0852818BD83Q41790733-5AE66143-A7D7-45A7-8241-4A942BBD5161Q42102346-943C5E8E-D474-4DFB-B29D-4E841885D8C2Q42289932-8F16E254-8C31-4135-8FCF-B7CBABC2549BQ42380933-6AC0BDAB-ACE7-4E95-9331-2AD1D9D95D17Q42398396-C41AAE64-7CD1-48AE-8DED-1FD64B0E0624Q42800304-D0528234-C44E-4817-9F00-1CD4A66E44EEQ43235877-E0270221-C3A4-4C0F-87D0-57DAFD6EF9BDQ43575401-30BA7FBC-DF2C-421D-82DB-BC70534E92F1Q44411229-F9BE3789-8DCB-4984-A5EA-5DDDD6659ADC
P2860
Fluorescence polarization competition assay: the range of resolvable inhibitor potency is limited by the affinity of the fluorescent ligand.
description
2003 nî lūn-bûn
@nan
2003 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Fluorescence polarization comp ...... ity of the fluorescent ligand.
@ast
Fluorescence polarization comp ...... ity of the fluorescent ligand.
@en
type
label
Fluorescence polarization comp ...... ity of the fluorescent ligand.
@ast
Fluorescence polarization comp ...... ity of the fluorescent ligand.
@en
prefLabel
Fluorescence polarization comp ...... ity of the fluorescent ligand.
@ast
Fluorescence polarization comp ...... ity of the fluorescent ligand.
@en
P356
P1476
Fluorescence polarization comp ...... ity of the fluorescent ligand.
@en
P2093
Xinyi Huang
P356
10.1177/1087057102239666
P577
2003-02-01T00:00:00Z