Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors - Wikidata - awgldk - TriplyDB

Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors

Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors

http://www.wikidata.org/entity/Q27677505

about

Microwave and continuous flow technologies in drug discovery.Syntheses of new tuberculosis inhibitors promoted by microwave irradiation Glutamate Dehydrogenase Is Required by Mycobacterium bovis BCG for Resistance to Cellular Stress.Glutamine Synthetase Drugability beyond Its Active Site: Exploring Oligomerization Interfaces and Pockets.Inhibition of glutamine synthetase: a potential drug target in Mycobacterium tuberculosis.Hybrid imidazole (benzimidazole)/pyridine (quinoline) derivatives and evaluation of their anticancer and antimycobacterial activity.Differential inhibition of adenylylated and deadenylylated forms of M. tuberculosis glutamine synthetase as a drug discovery platform.Silver-catalyzed [3 + 2] domino reaction: an efficient strategy to synthesize imidazole-5-carbaldehydes.Controllable access to multi-substituted imidazoles via palladium(ii)-catalyzed C-C coupling and C-N condensation cascade reactions.Antimycobacterial potentials of quercetin and rutin against H37Rv

P2860

Q34419675-25DEE8BB-BA73-4FD2-BDFC-1AC7D0F9220F Q35130531-C9E5092F-BDD2-4584-A63C-671F30AE6D1B Q35908562-A812A193-C0CF-4C35-BA9B-61B9976369EB Q36100472-47A42661-B182-4039-92D2-596EB8F5F127 Q38243884-B8B5116B-405D-4DB5-9DF2-BD113F85D15B Q38767138-09EDAF3A-9F92-404B-A1AF-9990E156F303 Q42369452-4F6B457B-BA9A-463D-ACB4-87C37BD00C4B Q47986413-9C68C4BD-0261-4F64-9222-9A30F8ABCA66 Q53099883-49E569D0-7C2C-4CF8-984C-11DF51F48944 Q57298353-3CE35F95-2F34-4688-8479-F9C5AFB1E4E5

P2860

Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors

http://www.wikidata.org/entity/Q27677505

description

2012 nî lūn-bûn

@nan

2012 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի մարտին հրատարակված գիտական հոդված

@hy

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

name

Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors

@ast

Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors

@en

Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors

@nl

type

label

Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors

@ast

Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors

@en

Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors

@nl

prefLabel

Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors

@ast

Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors

@en

Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors

@nl

P1433

Q27677505-702E7CA2-FDD6-48F0-A3B3-3D1D78066859

P1476

Q27677505-BAD6D71A-CE70-41B8-AF53-B66E0D0C33A7

P2093

Q27677505-01CC4917-BD1D-491D-9E00-2F7EE071E7B9

Q27677505-178B4363-9118-47A9-9183-9BB47D06F19F

Q27677505-257B7C6C-BACA-4A81-8DF1-8C2305A1415D

Q27677505-2DEE2407-1EA6-459C-976D-E3F1AA89E979

Q27677505-4C034E5A-E1DF-4C09-88A8-01DD8DE0D36F

Q27677505-8774F963-6E5E-47F1-B31C-5F8EF6EDFF8C

Q27677505-91325E5A-7A0C-4B31-8497-6B31BD873C50

Q27677505-A71EF460-1C18-44C3-826C-A6A96B0A821E

Q27677505-B4C75364-E253-452D-90E8-6104522F45CC

P2860

Q27677505-0BF717E6-251C-471E-A56A-0054DB4BFFB7

Q27677505-244061CA-0D6D-43DB-A231-58B0E885E2D9

Q27677505-27243FDD-E42A-4706-8E8B-F321D0564F03

Q27677505-30820D04-39D0-4EE7-AFCB-655A45060DBF

Q27677505-35C293C3-2A28-40A7-A1D6-8A17F1D56F8A

Q27677505-4BA396AB-9BD1-4FF3-8710-021F5CF5627D

Q27677505-69BAAFAC-6556-4569-B0B9-D829DA435310

Q27677505-8EEAF6E7-AAC3-485B-A4AF-F417D4E58B63

Q27677505-9622EE2F-3743-4F99-B4B1-38968A5F1EB1

Q27677505-AADB5A27-008C-47A6-B362-CE3F8C99C4B2

P304

Q27677505-77AE6D2A-ED43-474A-947D-0CBB066C5AFC

P31

Q27677505-1BBCAEC5-1DCF-43A3-8806-B72F12B202AF

P356

Q27677505-867195DC-204F-462C-A9D2-C8227E1A83DE

P407

Q27677505-A0354021-B9B3-4D6C-8DD2-ABC99180BC32

P433

Q27677505-2EDE6CD3-E2D0-42B6-B8A6-4A04C69AC2B7

P478

Q27677505-B9E32512-CBFB-444F-8C49-FE1F8A684A5F

P50

Q27677505-267D1F27-0DDB-4DDA-A6C3-2558CDA89958

Q27677505-6A076DCB-BA9C-4EE0-9267-A53F10D855CD

P577

Q27677505-F91437C3-5BA5-4B28-BD6B-D87ECAED4D45

P5875

Q27677505-5BDFDCDA-F0E8-4C14-9D3D-D018D5406F07

P698

Q27677505-7ED2CA99-3397-48E4-AC0E-C65CCC7B3AC3

P921

Q27677505-1499D288-0158-4C97-9603-27FF39B9A506

Q27677505-3A1C1856-E867-4A81-AAAC-3037B39FC2D9

P932

Q27677505-95220C2E-C2A0-42E7-AF34-CCB2D1FB4CE8

P356

P1433

Journal of Medicinal Chemistry

P1476

Trisubstituted imidazoles as Mycobacterium tuberculosis glutamine synthetase inhibitors

@en

P2093

Achyut M Sinha

http://www.w3.org/2001/XMLSchema#string

Anders Karlén

http://www.w3.org/2001/XMLSchema#string

Bachally R Srinivasa

http://www.w3.org/2001/XMLSchema#string

Harini Iyer

http://www.w3.org/2001/XMLSchema#string

Luke R Odell

http://www.w3.org/2001/XMLSchema#string

Mats Larhed

http://www.w3.org/2001/XMLSchema#string

Mikael T Nilsson

http://www.w3.org/2001/XMLSchema#string

Samir Yahiaoui

http://www.w3.org/2001/XMLSchema#string

Sherry L Mowbray

http://www.w3.org/2001/XMLSchema#string

P2860

Structural basis for the inhibition of Mycobacterium tuberculosis glutamine synthetase by novel ATP-competitive inhibitors

Structural model for the reaction mechanism of glutamine synthetase, based on five crystal structures of enzyme-substrate complexes

Treatment of Mycobacterium tuberculosis with antisense oligonucleotides to glutamine synthetase mRNA inhibits glutamine synthetase activity, formation of the poly-L-glutamate/glutamine cell wall structure, and bacterial replication.

Rapid palladium-catalyzed synthesis of esters from aryl halides utilizing Mo(CO)(6) as a solid carbon monoxide source.

A new structural theme in C2-symmetric HIV-1 protease inhibitors: ortho-substituted P1/P1' side chains.

Evaluation of the amino acid binding site of Mycobacterium tuberculosis glutamine synthetase for drug discovery.

Structure of Mycobacterium tuberculosis glutamine synthetase in complex with a transition-state mimic provides functional insights.

Glutamine synthetase of Mycobacterium tuberculosis: extracellular release and characterization of its enzymatic activity

An inhibitor of exported Mycobacterium tuberculosis glutamine synthetase selectively blocks the growth of pathogenic mycobacteria in axenic culture and in human monocytes: extracellular proteins as potential novel drug targets.

Inhibition of Mycobacterium tuberculosis glutamine synthetase as a novel antibiotic strategy against tuberculosis: demonstration of efficacy in vivo.

P304

2894-2898

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1021/JM201212H

http://www.w3.org/2001/XMLSchema#string

P407

P433

6

http://www.w3.org/2001/XMLSchema#string

P478

55

http://www.w3.org/2001/XMLSchema#string

P50

P577

2012-03-08T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

221865370

http://www.w3.org/2001/XMLSchema#string

P698

22369127

http://www.w3.org/2001/XMLSchema#string

P921

Mycobacterium tuberculosis

P932

3381009

http://www.w3.org/2001/XMLSchema#string